Review
Oncology
Michael Maranzano, Monica Mead
Summary: Despite the successful use of frontline anthracycline-based chemotherapy for cHL, a significant portion of patients do not respond adequately and require additional therapy. AutoHCT can provide a lasting response for 50% of transplant-eligible patients, while alloHCT may be necessary for refractory patients. The use of salvage therapy, including chemotherapy and novel agents, has expanded the applicability of transplantation. Rating: 8/10
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Wenjing Zhang, Fan Du, Li Wang, Tao Bai, Xiang Zhou, Heng Mei
Summary: Epidemiological studies have found a connection between hepatitis C virus (HCV) and hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL) over the past decade. The regression of HCV-associated NHL after HCV eradication provides strong evidence for the role of HCV infection in lymphoproliferative diseases. HBV infection has been shown to significantly increase the incidence of NHL. The exact mechanisms of HCV and HBV leading to NHL are still not fully understood, but they involve the effects of viral presence on B lymphocytes.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Pathology
Liwei Ruan, Songou Zhang, Xiaozhen Chen, Wenqing Liang, Qiong Xie
Summary: This article discusses the role of angiogenic factors in breast cancer pathogenesis and reviews therapeutic approaches based on anti-angiogenic factors. It highlights the importance of balancing angiogenic and anti-angiogenic factors in preventing tumor growth and metastasis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Hematology
Ananth Shankar, Georgina W. Hall, Pam McKay, Eve Gallop-Evans, Patrick Fielding, Graham P. Collins
Summary: This consensus statement proposes a management approach for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in patients of all ages and all stages. It includes recommendations for diagnosis, staging, and risk-stratified management, including active surveillance, low- and standard-dose immunochemotherapy, and radiotherapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Medicine, General & Internal
Jesko Momotow, Sven Borchmann, Dennis A. Eichenauer, Andreas Engert, Stephanie Sasse
Summary: Hodgkin lymphoma (HL) is a rare malignancy primarily affecting young patients, with a second peak in patients above 60 years old. Treatment advancements have led to an impressive 80% cure rate, transforming HL from an incurable disease to one with excellent prognosis. Innovative approaches such as antibody drug conjugates and immunomodulatory drugs are showing promising results and becoming more widely used in earlier treatment lines.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Angelica Maria Gamboa-Cedeno, Mariangeles Diaz, Nancy Cristaldo, Victoria Otero, Natalia Schutz, Dorotea Fantl, Silvana Cugliari, Marta Zerga, Erica Rojas-Bilbao, Federico Jauk, Hernan Garcia Rivello, Myriam Nunez, Stella Maris Ranuncolo
Summary: The study highlights the potential of BCL-2 as a prognostic biomarker and a new therapeutic target in classical Hodgkin Lymphoma (cHL). Additionally, it reveals the cytotoxic effect of venetoclax in human cHL cell lines for the first time.
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Andrzej Pawlik
Summary: Connexins are involved in intercellular communication through hemichannels and gap junctions, playing a crucial role in regulating cell homeostasis, proliferation, and differentiation. Changes in Cx distribution, degradation, and post-translational modifications have been linked to cancer, cardiovascular, and neurological diseases. Depending on the isoform, Cx can either promote or suppress the development of atherosclerosis by affecting endothelial dysfunction, monocyte recruitment, vascular smooth muscle cell activation, or autophagy inhibition. Inhibition or modulation of specific Cx isoforms could potentially serve as therapeutic targets in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Cheng-Ning Yang, Sze-Kwan Lin, Sang-Heng Kok, Han-Wei Wang, Yuan-Ling Lee, Chia-Tung Shun, Chih-Wen Chi, Hsiang Yang, Chi-Yuan Hong
Summary: The study revealed that SIRT5 plays a crucial role in the progression of apical periodontitis, and overexpression of SIRT5 can alleviate hypoxia-induced oxidative stress and apoptosis, suggesting its therapeutic potential for apical periodontitis.
Article
Health Care Sciences & Services
Jeremy A. Meier, Barbara Savoldo, Natalie S. Grover
Summary: Treatment for Hodgkin lymphoma has advanced significantly, but a portion of patients still experience relapse or disease progression. Immunotherapies, particularly CAR T cells, have shown exceptional promise in treating relapsed/refractory HL.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Hematology
Lucy C. Fox
Summary: In this study, Flerlage et al performed whole genome sequencing on individuals with and without Hodgkin lymphoma (HL) in families with a family history of the disease. They identified risk variants for HL and provided a starting point for further investigation of these variants in other HL patients and their families.
Editorial Material
Hematology
Graham P. Collins
Summary: In this study, combining the histone deacetylase inhibitor vorinostat with the programmed cell death protein-1 inhibitor pembrolizumab resulted in a remarkable response rate, even in patients refractory to prior PD1i therapy.
Article
Hematology
Pamela B. Allen, Hatice Savas, Andrew M. Evens, Ranjana H. Advani, Brett Palmer, Barbara Pro, Reem Karmali, Eric Mou, Jeffrey Bearden, Gary Dillehay, Robert A. Bayer, Robert M. Eisner, Joan S. Chmiel, Kaitlyn O'Shea, Leo I. Gordon, Jane N. Winter
Summary: Brief pembrolizumab monotherapy followed by AVD is highly effective and safe for patients with newly diagnosed classical Hodgkin lymphoma, including those with bulky disease.
Review
Immunology
Xueyang Zou, Yi Zhang, Xiaoya Wang, Rongchao Zhang, Wei Yang
Summary: The causes of infertility are still unclear, but studies have found that AIRE deficiency might be related to infertility, possibly due to the production of autoantibodies against sperm, poor development of germ cells, and abnormal ovarian function.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Marc A. Weniger, Ralf Kuppers
Summary: Classical Hodgkin lymphoma (cHL) has unique biological features such as the orchestration of a complex microenvironment by HRS cells, the major role of Epstein-Barr virus in lymphomagenesis, and the defining interplay of genetic lesions and cellular origin. These factors contribute to the constitutive activation of multiple signaling pathways in cHL.
Article
Oncology
Luise Eckardt, Maria Prange-Barczynska, Emma J. Hodson, James W. Fielding, Xiaotong Cheng, Joanna D. C. C. Lima, Samvid Kurlekar, Gillian Douglas, Peter J. Ratcliffe, Tammie Bishop
Summary: The study revealed the importance of the PHD2/HIF-2α pathway in adrenal development in pseudohypoxic PPGL, with combined inactivation of Phd2 and Hif-2α resulting in changes in gene expression patterns and morphological abnormalities in adrenal medullary cells.
ENDOCRINE-RELATED CANCER
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Yingying Cao, Simo Kitanovski, Ralf Kueppers, Daniel Hoffmann
NATURE BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sandra Winning, Joachim Fandrey
Summary: Oxygen deprivation is a common feature at inflamed sites, and immune cells adapt to this condition by activating HIF. HIF plays a significant role in regulating the inflammatory phenotype of immune cells, including migration, phagocytosis, and induction of inflammatory cytokines. However, further research is needed to understand the specific roles of HIF-1 and HIF-2 in different cell types.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Immunology
Vera Schuetzhold, Jan Gravemeyer, Anne Bicker, Thomas Hager, Claudia Padberg, Jana Schaefer, Anna Wrobeln, Melanie Steinbrink, Seher Zeynel, Thomas Hankeln, Juergen Christian Becker, Joachim Fandrey, Sandra Winning
Summary: Inflammatory bowel disease can promote the development of colorectal cancer, and hypoxia is a characteristic of both inflammation and solid tumors. Prolyl hydroxylases and factor-inhibiting HIF (FIH) negatively regulate HIF and may act as tumor suppressors in colorectal cancer development. This study found that knockout of FIH in colon epithelial cells did not modulate colorectal cancer development but reduced the inflammatory response in chronic colitis.
JOURNAL OF IMMUNOLOGY
(2022)
Editorial Material
Neurosciences
Joachim Fandrey
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Editorial Material
Physiology
Helmut Acker, Joachim Fandrey
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Wrobeln, Tristan Leu, Jadwiga Jablonska, Urban Geisthoff, Stephan Lang, Joachim Fandrey, Freya Droege
Summary: Patients with hereditary haemorrhagic telangiectasia (HHT) suffer from abnormal vessel structures, leading to vessel hemorrhage and shunt effects. This study found significantly decreased expression of HIF-1 alpha in HHT patients, with no effect on the known upstream regulators of HIF-1 alpha. The results highlight the importance of HIF in HHT and suggest an interaction between the known HHT mutation and HIF-1 alpha dysregulation in HHT patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Patricia Johansson, Anja Eckstein, Ralf Kueppers
Summary: Ocular adnexal marginal zone lymphoma (OAMZL) is a distinct type of lymphoma that occurs in tissues around the eyeball. The development of this lymphoma is associated with the constitutive activation of the NF-kappa B pathway, which may be caused by genetic alterations and epigenetic changes. The mucosa-associated lymphatic tissue (MALT) subtype is the most common subtype of lymphoma in the ocular adnexa.
Article
Biochemistry & Molecular Biology
Barbara Uhl, Katharina T. Prochazka, Katrin Pansy, Kerstin Wenzl, Johanna Strobl, Claudia Baumgartner, Marta M. Szmyra, James E. Waha, Axel Wolf, Peter Tomazic, Elisabeth Steinbauer, Maria Steinwender, Sabine Friedl, Marc Weniger, Ralf Kueppers, Martin Pichler, Hildegard T. Greinix, Georg Stary, Alan G. Ramsay, Benedetta Apollonio, Julia Feichtinger, Christine Beham-Schmid, Peter Neumeister, Alexander J. Deutsch
Summary: Chemokine receptors and their ligands play an important role in the development of DLBCL, follicular lymphoma, and RS. This study found that the expression profiles of chemokine receptors in de novo DLBCL and tFL were significantly different from that of GC-B and RS. High expression of CCR7 was associated with poor overall survival in patients with de novo DLBCL and tFL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yoshiyuki Henning, Ursula Sarah Blind, Safa Larafa, Johann Matschke, Joachim Fandrey
Summary: This study reveals that HIF stabilization exacerbates iron-dependent cell death in RPE cells under oxidative stress conditions. The Fenton reaction triggered by increased superoxide dismutase (SOD) activity and elevated intracellular iron levels plays a critical role in this process.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Abigaelle Pelletier, Eric Nelius, Zheng Fan, Ekaterina Khatchatourova, Abdiel Alvarado-Diaz, Jingyi He, Ewelina Krzywinska, Michal Sobecki, Shunmugam Nagarajan, Yann Kerdiles, Joachim Fandrey, Dagmar Gotthardt, Veronika Sexl, Katrien de Bock, Christian Stockmann
Summary: Natural killer (NK) cells exhibit different metabolic programs in resting and activated states, regulated by the oxygen-sensitive transcription factor HIF-1 alpha. In resting NK cells, HIF-1 alpha regulates tryptophan metabolism and cellular NAD(+) levels, preventing DNA damage and NK cell apoptosis. In activated NK cells under hypoxia, HIF-1 alpha drives glycolysis and enhances NK cell performance. These findings highlight the importance of HIF-1 alpha in regulating NK cell metabolism and function.
Article
Biochemistry & Molecular Biology
Bjort K. Kragesteen, Amir Giladi, Eyal David, Shahar Halevi, Laufey Geirsdottir, Olga M. Lempke, Baoguo Li, Andreas M. Bapst, Ken Xie, Yonatan Katzenelenbogen, Sophie L. Dahl, Fadi Sheban, Anna Gurevich-Shapiro, Mor Zada, Truong San Phan, Roberto Avellino, Shuang-Yin Wang, Oren Barboy, Shir Shlomi-Loubaton, Sandra Winning, Philipp P. Markwerth, Snir Dekalo, Hadas Keren-Shaul, Merav Kedmi, Martin Sikora, Joachim Fandrey, Thorfinn S. Korneliussen, Josef T. Prchal, Barak Rosenzweig, Vladimir Yutkin, Fernando Racimo, Eske Willerslev, Chamutal Gur, Roland H. Wenger, Ido Amit
Summary: Single-cell RNA and transposase-accessible chromatin (ATAC) sequencing in a mouse model identified a rare cell subset called Norn cells in kidney stroma as the major source of endocrine Epo production in mice, and this finding was confirmed in human kidney tissues. These findings provide new insights into EPO gene regulation and may lead to improved therapies for anemia.
Article
Multidisciplinary Sciences
Mostafa A. Aboouf, Julia Armbruster, Franco Guscetti, Markus Thiersch, Andreas Boss, Axel Goedecke, Sandra Winning, Claudia Padberg, Joachim Fandrey, Glen Kristiansen, Anne Bicker, Thomas Hankeln, Max Gassmann, Thomas A. Gorr
Summary: Myoglobin expression in breast cancer influences tumor growth, metastasis, tumor hypoxia, and chemotherapy response. Determining the expression level of myoglobin in malignant breast cancer biopsies can improve tumor stratification, outcome prediction, and personalized therapy.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Hematology
Ralf Kueppers
Summary: In this study, the authors demonstrate that inhibiting mRNA translation with flavagline FL3 has multiple effects on CLL cells, including blocking proliferation, rewiring MYC-driven metabolism, and controlling CLL growth in a murine model.
Article
Biology
Yves Schild, Jonah Bosserhoff, Freya Droege, Elisabeth Littwitz-Salomon, Joachim Fandrey, Anna Wrobeln
Summary: The interaction between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-fi) plays a critical role in inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), impairment of the TGF-beta pathway leads to decreased HIF-1 alpha accumulation, which results in immunodeficiency in these patients.
Article
Biochemistry & Molecular Biology
Tristan Leu, Jannik Denda, Anna Wrobeln, Joachim Fandrey
Summary: The ability of cells to communicate with their surroundings is essential for important cellular processes. In this study, it was found that the protein intraflagellar transport 88 homolog (IFT88) directly interacts with hypoxia-inducible factor-2 alpha (HIF-2 alpha) in murine neuronal cells. Under hypoxic conditions, HIF-2 alpha accumulates in the primary cilia and promotes ciliary elongation. Loss of HIF-2 alpha affects ciliary signaling and decreases the transcription of Mek1/2 and Erk1/2 in neuronal cells.
MOLECULAR AND CELLULAR BIOLOGY
(2023)