Review
Cell Biology
Xinyi Lv, Xiaomin Liu, Ming Zhao, Haijing Wu, Wuiguang Zhang, Qianjin Lu, Xiangmei Chen
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with limited targeted therapy. Recent studies suggest that RNA methylation may be related to the pathogenesis of SLE. Although some evidence supports the association between RNA methylation and SLE pathogenesis, further in-depth research and analysis are needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sebastian Bruera, Thandiwe Chavula, Riya Madan, Sandeep. K. K. Agarwal
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations. Recent studies have highlighted the important role of the type I interferon (IFN) pathway in SLE pathogenesis. Therapeutic strategies targeting type I IFN and related pathways are being developed for the treatment of SLE. This review discusses the role of type I IFN in SLE pathogenesis and its potential as a biomarker and therapeutic target for SLE patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yali Feng, Jing Fang, Yan Zhao, Shuyue Ye, Anna Wang, Yuqi Zhang, Jinfeng Zhu, Jiachen Li, Zhengzhong Lv, Zhongsheng Zhao, Haibin Shi
Summary: In this study, a near-infrared light-mediated mitochondrial RNA modification approach was developed for long-term imaging and effective tumor suppression. A tumor-targetable NIR fluorescent probe f-CRI was synthesized and it could covalently bind to mtRNA upon 808 nm irradiation, leading to prolonged retention in tumors. The covalent modification of mtRNA by f-CRI disrupted mitochondrial function and significantly suppressed tumor growth. This approach provides a potential strategy for cancer RNA interference therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Virology
Ancuta Lupu, Ingrith Crenguta Miron, Cristina Gavrilovici, Anca Adam Raileanu, Iuliana Magdalena Starcea, Ileana Ioniuc, Alice Azoicai, Adriana Mocanu, Lacramioara Ionela Butnariu, Felicia Dragan, Vasile Valeriu Lupu
Summary: Pediatric systemic lupus erythematosus is a chronic autoimmune disorder with a highly variable course and prognosis. The use of immunosuppressive therapies and underlying comorbidities increase the risk of severe COVID-19 and poor outcomes in pediatric SLE patients. This review analyzes newly diagnosed cases of pediatric SLE following COVID-19 and examines the impact of COVID-19 on patients with existing pediatric SLE.
Article
Cell Biology
Paulo Rogerio Julio, Thais Caldeira, Gustavo Retuci Pinheiro, Carla Helena Capello, Renan Bazuco Fritolli, Roberto Marini, Fernando Cendes, Paula Teixeira Fernandes, Lilian T. L. Costallat, Leticia Rittner, Simone Appenzeller
Summary: Central nervous system (CNS) involvement is common in childhood-onset systemic lupus erythematosus (cSLE), with structural magnetic resonance imaging (MRI) showing global cerebral atrophy and specific involvement of the corpus callosum and hippocampus. A cross-sectional study compared 71 cSLE patients to two control groups, revealing reduced mid-sagittal area of the corpus callosum in both cSLE and adult-onset SLE (aSLE) patients, compared to healthy controls. Microstructural changes, including lower FA values and higher MD, RD, and AD values, were observed in cSLE patients, particularly in the posterior region of the corpus callosum. These changes were associated with low complement levels, presence of anticardiolipin antibodies, and cognitive impairment. Overall, adults with cSLE showed greater microstructural changes in the corpus callosum compared to aSLE, potentially explaining the more severe cognitive impairment and disability observed in cSLE.
Review
Cell Biology
Fernando Lizcano, Lizeth Bustamante
Summary: Epigenetic changes induced by environmental factors play a significant role in cardiovascular diseases, particularly in cardiac hypertrophy. Reactivation of fetal genes caused by various pathologies is a common molecular component in cardiac hypertrophy. However, the impact of these molecular changes on therapeutic strategies is still relatively limited. Recently, new information has been discovered about the proteins that modify gene expression in cardiac hypertrophy. These proteins covalently modify DNA and induce changes in chromatin structure. The relationship between histones and DNA has a significant influence on gene expression influenced by the environment, leading to epigenetic variations. The regulation of pathological cardiac hypertrophy through epigenetic modifications involves changes in genomic stability, chromatin architecture, and gene expression. Histone 3 trimethylation at lysine 4, 9, or 27 (H3-K4; -K9; -K27me3) and histone demethylation at lysine 9 and 79 (H3-K9; -K79) are important mediators of reprogramming in pathologic hypertrophy. Among the chromatin architecture modifiers, histone demethylases are a group of proteins that play a crucial role in cardiac cell differentiation and may also contribute to the development of cardiac hypertrophy. In this review, we provide an overview of the current understanding of the influence of epigenetic modifications on gene expression involved in cardiac hypertrophy and potential therapeutic approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi, Ninghan Feng
Summary: The microbiome alterations in the gut and oral cavity are associated with the development of systemic lupus erythematosus (SLE). Research on 35 SLE patients revealed reduced bacterial richness and diversity in feces, and increased bacterial diversity in saliva. These findings suggest that different body niches in SLE patients have distinct bacterial profiles that may play a role in the disease development.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Iwona Sudol-Szopinska, Ewa Zelnio, Marzena Olesinka, Piotr Gietka, Sylwia Ornowska, Deborah Jane Power, Mihra S. Taljanovic
Summary: This paper illustrates musculoskeletal imaging features in three clinical forms of systemic lupus erythematosus (SLE), including nondeforming nonerosive arthritis, deforming nonerosive arthropathy, and erosive arthropathy. Advances in imaging, such as ultrasound and magnetic resonance imaging (MRI), play a significant role in the diagnosis and follow-up of musculoskeletal manifestations of SLE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Tao Wang, Xiaojun Li, Xiaojing Zhang, Qing Wang, Wenqian Liu, Xiaohong Lu, Shunli Gao, Zixi Liu, Mengshuang Liu, Lihong Gao, Wenna Zhang
Summary: A large number of RNA molecules have been found in the phloem of higher plants, where specific RNA motifs and structures facilitate their mobility, while RNA methylation, such as m5C, plays a crucial role in RNA transport. These studies provide a theoretical foundation for uncovering the mechanism of RNA transportation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Imene Melki, Isabelle Allaeys, Nicolas Tessandier, Tania Levesque, Nathalie Cloutier, Audree Laroche, Nathalie Vernoux, Yann Becker, Hadrien Benk-Fortin, Anne Zufferey, Emmanuelle Rollet-Labelle, Marc Pouliot, Guy Poirier, Natacha Patey, Clemence Belleannee, Denis Soulet, Steven E. McKenzie, Alain Brisson, Marie-Eve Tremblay, Christian Lood, Paul R. Fortin, Eric Boilard
Summary: The study reveals that platelets release mitochondrial DNA in patients with SLE, and this process is associated with platelet degranulation and requires stimulation of platelet Fc-γ-RIIA.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yasuko Arao, Mika Nakayama, Yoshiko Tsuji, Yumiko Hamano, Chihiro Otsuka, Andrea Vecchione, Ken Ofusa, Hideshi Ishii
Summary: MicroRNAs (miRNAs) synthesized through a canonical pathway play important roles in human diseases. IsomiRs, variations in noncoding miRNAs, are generated through a non-canonical pathway. EpisomiRs, miRNAs with different modifications, are expanding the isomiR family. IsomiRs reflect cell-specific biological function and studying episomiRs and isomiRs can contribute to optimizing diagnosis and therapeutic technology for precision medicine.
Review
Immunology
Mohamed J. Saadh, Khadijehsadat Kazemi, Hossein Khorramdelazad, Mohammad Javad Mousavi, Negar Noroozi, Maryam Masoumi, Jafar Karami
Summary: Evidence suggests that T cells play a role in the development of SLE and have different metabolic pathways. Metabolic processes and enzymes determine the function of T cells in inflammatory and autoimmune responses. Dysregulation of metabolism in SLE T cells has been found, and drugs targeting autoreactive T cell metabolism could be a promising therapeutic approach for SLE treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Roni Meidan, Ofir Elalouf, Riva Tauman, Victoria Furer, Ari Polachek, Jonathan Wollman, Tali Eviatar, Michael Zisapel, David Levartovsky, Estelle Seyman, Ori Elkayam, Daphna Paran
Summary: Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. The results showed that SLE patients had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. The findings suggest that active disease and accumulated damage may be associated with OSA, highlighting the importance of identifying OSA in patients with SLE.
Article
Biology
Zenat Ahmed Khired, Shahad W. Kattan, Ahmad Khuzaim Alzahrani, Ahmad J. Milebary, Mohammad H. Hussein, Safaa Y. Qusti, Eida M. Alshammari, Eman A. Toraih, Manal S. Fawzy
Summary: This study investigated the association of the miR-27a gene (MIR27A) rs11671784G/A variant with systemic lupus erythematosus (SLE) risk/severity. The results showed that the MIR27A rs11671784 variant may have a protective effect against SLE susceptibility/risk, while the G/G genotype was associated with increased SLE risk.
Article
Immunology
Guillaume Seret, Felipe Canas, Laurence Pougnet-Di Costanzo, Catherine Hanrotel-Saliou, Sandrine Jousse-Joulin, Yannick Le Meur, Alain Saraux, Antoine Valeri, Chaim Putterman, Pierre Youinou, Adriana Rojas-Villarraga, Juan-Manuel Anaya, Yves Renaudineau
JOURNAL OF AUTOIMMUNITY
(2015)
Review
Hematology
Felipe Canas, Laurent Simonin, Francis Couturaud, Yves Renaudineau
THROMBOSIS RESEARCH
(2015)
Article
Neurosciences
C. A. Arango-Davila, A. Vera, A. C. Londono, A. F. Echeverri, F. Canas, C. F. Cardozo, J. L. Orozco, J. Rengifo, C. A. Canas
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2015)
Article
Rheumatology
Carlos Alberto Canas, Felipe Canas, Jorge Hernan Izquierdo, Andres-Felipe Echeverri, Mauricio Mejia, Fabio Bonilla-Abadia, Gabriel J. Tobon
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2014)
Review
Immunology
Yosra Thabet, Felipe Canas, Ibtissem Ghedira, Pierre Youinou, Rizgar A. Mageed, Yves Renaudineau
JOURNAL OF AUTOIMMUNITY
(2012)
Article
Cardiac & Cardiovascular Systems
Juan C. Diaz, Felipe Canas, Mauricio Duque, Julian Aristizabal, Cesar Nino, Oriana Bastidas, Jorge Marin, Estefania Rivera, Carolina Hoyos, Carlos Matos, Adelqui Peralta, David T. Martin, Jorge Romero
Summary: This study describes the use of an assisted reality device in providing healthcare support for patients with cardiac implantable electronic devices (CIEDs) in rural areas. The results show that remote assistance has the potential to overcome difficulties associated with accessing specialized healthcare in difficult-to-reach areas, providing significant social and clinical impact to remote populations.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Felipe Canas, Eduardo Orrego-Gonzalez, Daniel Eduardo-Celin, Jorge Martinez B, Liliana Mesa Ramirez
JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES
(2019)
Article
Cardiac & Cardiovascular Systems
Felipe Canas, Juan David Lopez Ponce de Leon, Juan Esteban Gomez, Carlos Alberto Canas
EUROPEAN HEART JOURNAL-CASE REPORTS
(2019)
Review
Immunology
Carlos A. Canas, Felipe Canas
AUTOIMMUNE DISEASES
(2012)
