期刊
WATER RESEARCH
卷 46, 期 7, 页码 2469-2477出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.watres.2012.02.013
关键词
Carbamazepine; Degradation; Hydrodynamic cavitation; Acoustic cavitation; ELISA
资金
- BAM (Berlin)
The antiepileptic drug carbamazepine is one of the most abundant pharmaceuticals in the German aquatic environment. The effect of low carbamazepine concentrations (1-50 mu g L-1) is discussed controversially, but ecotoxicological studies revealed reproduction toxicity, decreased enzymatic activity and bioaccumulation in different test organisms. Therefore, as a preventive step, an efficient and cost-effective technique for wastewater treatment plants is needed to stop the entry of pharmaceuticals into the aquatic environment. Cavitation, the formation, growth, and subsequent collapse of gas- or vapor-filled bubbles in fluids, was applied to solve this problem. The technique of Hydrodynamic-Acoustic-Cavitation was used showing high synergistic effect. Under optimized conditions carbamazepine (5 mu g L-1) was transformed by pseudo-first order kinetics to an extent of >96% within 15 min (27% by hydrodynamic cavitation, 33% by acoustic cavitation). A synergistic effect of 63% based on the sum of the single methods was calculated. Carbamazepine concentrations were monitored by a sensitive and selective immunoassay and after 60 min no known metabolites were detectable by LC-MS/MS. (C) 2012 Published by Elsevier Ltd.
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