Article
Immunology
Xiaowei Gai, Huawei Wang, Yaqing Li, Haotian Zhao, Cong He, Zihui Wang, Heling Zhao
Summary: The study found that fecal microbiota transplantation (FMT) can reduce morbidity and mortality in septic mice, restore the abundance and diversity of the gut flora, improve intestinal barrier function, and reduce inflammation. Lachnospiraceae was identified as contributing the most to intestinal protection through enhancement of the L-lysine fermentation pathway. FMT offers a microbe-mediated survival advantage in a murine model of sepsis, suggesting new therapeutic strategies for patients with sepsis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Dianbo Yao, Wanlin Dai, Ming Dong, Chaoliu Dai, Shuodong Wu
Summary: The MUC2 mucus barrier plays a crucial role in ulcerative colitis (UC). Interventions such as dietary adjustment, repair of the mucus barrier, microbiota transplantation, and targeted elimination of pathogenic bacteria can reduce the occurrence and recurrence of UC, maintaining a long-term remission period.
Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Article
Immunology
Yuyuan Li, Man Liu, He Liu, Xue Sui, Yinhui Liu, Xiaoqing Wei, Chunzheng Liu, Yiqin Cheng, Weikang Ye, Binbin Gao, Xin Wang, Qiao Lu, Hao Cheng, Lu Zhang, Jieli Yuan, Ming Li
Summary: This study demonstrated that CB RH2 can modulate ceftriaxone-induced dysbacteriosis by altering gut microbiota diversity, improving colonic architecture and intestinal integrity, reducing inflammation, and positively impacting the immune system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Barbara Skrzydlo-Radomanska, Bozena Cukrowska
Summary: Small Intestinal Bacterial Overgrowth (SIBO) is a form of dysbiosis that involves excessive bacterial colonization in the small intestine, with some bacteria more typical of the colon microbiota. The prevalence of SIBO has been estimated to range from 2.5% to 22%, increasing with age and comorbidities. The availability of noninvasive breath tests has led to an increase in diagnosed SIBO cases. This review provides an overview of the pathophysiology, manifestations, diagnostics, and recommended management of SIBO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xinyue Wang, Sisi Lin, Lu Wang, Zhenping Cao, Mengmeng Zhang, Yifan Zhang, Rui Liu, Jinyao Liu
Summary: Outer membrane vesicles (OMVs) released by Akkermansia muciniphila can restore gut microbiota balance, stimulate mucosal immunoglobulin A response, and maintain intestinal barrier integrity by entering intestinal epithelial cells. Transplanting gut microbiota-derived OMVs can alleviate colitis and enhance anti-PD-1 therapy against colorectal cancer. This study highlights the important role of gut microbiota-derived OMVs in intestinal ecology and provides a new target for disease intervention and treatment.
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Review
Gastroenterology & Hepatology
Rohma Ghani, Benjamin H. Mullish, Lauren A. Roberts, Frances J. Davies, Julian R. Marchesi
Summary: Disruption to the intestinal microbiota increases the risk of infection, and restoring its composition is a potential strategy to mitigate this risk. Fecal microbiota transplantation is currently the major therapeutic approach, with potential use in treating other infectious diseases.
Article
Biochemistry & Molecular Biology
Lixia Kai, Xin Zong, Qin Jiang, Zeqing Lu, Fengqin Wang, Yizhen Wang, Tenghao Wang, Mingliang Jin
Summary: The water-soluble polysaccharides AMP from Atractylodes macrocephalae Koidz. have protective effects on intestinal mucosal barrier injury induced by DSS in mice. AMP alleviates body weight decreases, shortens colon length, ameliorates colonic damage, decreases proinflammatory cytokines, and modulates intestinal microbiota to increase beneficial bacteria ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Ning He, Gerong Shen, Xiaoqin Jin, Heyangzi Li, Jingyu Wang, Lintao Xu, Jun Chen, Xi Cao, Chunyan Fu, Dongling Shi, Xinghui Song, Shuangshuang Liu, Yanwei Li, Tengfei Zhao, Jun Li, Jinjie Zhong, Yueliang Shen, Mingzhi Zheng, Ying-ying Chen, Lin-lin Wang
Summary: Spinal cord injury can alter the gut microbiota and metabolites, affecting the prognosis of the injury. Resveratrol, with its anti-inflammatory properties, can restore the disrupted gut microbiota and increase the concentration of butyrate, promoting functional recovery after spinal cord injury.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Microbiology
Qianqian Xu, Huafeng Jian, Wenyan Zhao, Jiankui Li, Xiaoting Zou, Xinyang Dong
Summary: This study evaluated the effects of early weaning stress on intestinal functions in squabs. The results showed that weaning stress had negative effects on the growth performance and intestinal barrier functions of squabs. It also caused disturbance in intestinal microbiota and activation of inflammation cell responses.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ling Wei, Xue-Sen Wen, Cory J. Xian
Summary: Chemotherapy-induced intestinal mucositis is a painful condition that affects a significant number of patients undergoing chemotherapy. Recent research has highlighted the relationship between dysbiosis of intestinal microbiota and mucositis, showing that chemotherapy can shape the microbiota and worsen mucositis through TLR signaling pathways. This review aims to explore how gut microbiota affects the pathogenesis of mucositis and provide potential new strategies for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Aki Ronkainen, Imran Khan, Eva Krzyzewska-Dudek, Kaisa Hiippala, Tobias L. Freitag, Reetta Satokari
Summary: Fecal microbiota transplantation (FMT) is commonly used to treat recurrent Clostridioides difficile infection (rCDI) and is being investigated for the treatment of other gut microbiota-related conditions. This study found that selected Bifidobacterium strains from FMT donors, such as DX_pv23, have the potential to colonize the recipient's gut and restore antibiotic-disturbed microbiota. The study also revealed that DX_pv23 expressed genes related to adherence and pilus formation, which may contribute to its therapeutic effects.
Article
Microbiology
Yunxia Li, Wei Zhu, Yan Jiang, Duncan James Lessing, Weihua Chu
Summary: Bacterial vaginosis (BV) is a disease caused by an imbalance in the vaginal microbiota. This study suggests using synthetic bacterial consortia transplantation (SBCT) as a potential treatment for BV induced by Gardnerella vaginalis. The results showed that SBCT reduced tissue damage, restored the vaginal microbiota, decreased pro-inflammatory cytokine secretion, and suppressed inflammation-related gene expression. However, vaginal microbiota transplantation (VMT) was more effective in suppressing G. vaginalis-induced inflammation. Overall, synthetic bacterial consortia have the potential to be used as a biotherapeutic agent for the treatment of G. vaginalis-induced BV.
Review
Food Science & Technology
Yuhan Zhao, Mengjie Li, Yanan Wang, Ruixuan Geng, Jingjing Fang, Qing Liu, Seong-Gook Kang, Wei Cai Zeng, Kunlun Huang, Tao Tong
Summary: This article discusses the relationship between diet and gut microbiota, the mechanism linking diabetes and gut dysbiosis, and the effects of dietary components on diabetes from the perspective of modulating gut microbiota. It provides compelling evidence that targeting gut microbiota through dietary interventions is a promising strategy for the clinical management of diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)