期刊
VISUAL NEUROSCIENCE
卷 31, 期 4-5, 页码 317-332出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S095252381400008X
关键词
Neural retina; Retinal pigmented epithelium; Human pluripotent stem cells; Differentiation; Age related macular degeneration (AMD); Hereditary retinal dystrophies (HRDs)
资金
- Fight for Sight UK [1456/1457]
- RP Fighting Blindness UK [GR5840]
- BBSRC UK [BB/I02333X/1]
- European Research Council [614620]
- Sunderland Eye Infirmary
- Macular Disease Society UK
- Biotechnology and Biological Sciences Research Council [BB/I02333X/1] Funding Source: researchfish
- Fight for Sight [1456/57] Funding Source: researchfish
- BBSRC [BB/I02333X/1] Funding Source: UKRI
Blindness represents an increasing global problem with significant social and economic impact upon affected patients and society as a whole. In Europe, approximately one in 30 individuals experience sight loss and 75% of those are unemployed, a social burden which is very likely to increase as the population of Europe ages. Diseases affecting the retina account for approximately 26% of blindness globally and 70% of blindness in the United Kingdom. To date, there are no treatments to restore lost retinal cells and improve visual function, highlighting an urgent need for new therapeutic approaches. A pioneering breakthrough has demonstrated the ability to generate synthetic retina from pluripotent stem cells under laboratory conditions, a finding with immense relevance for basic research, in vitro disease modeling, drug discovery, and cell replacement therapies. This review summarizes the current achievements in pluripotent stem cell differentiation toward retinal cells and highlights the steps that need to be completed in order to generate human synthetic retinae with high efficiency and reproducibly from patient-specific pluripotent stem cells.
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