期刊
VISION RESEARCH
卷 51, 期 2, 页码 280-287出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2010.08.010
关键词
Mouse; Scotopic; Melanopsin; Electroretinogram; Connexin
资金
- NEI NIH HHS [R01 EY014127, EY014127] Funding Source: Medline
- NIGMS NIH HHS [R01 GM037751, GM37751] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36(-/-)) and carrying a mutation that disrupts cone phototransduction (Gnat2(cpfl3)). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus. (C) 2010 Elsevier Ltd. All rights reserved.
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