期刊
VISION RESEARCH
卷 48, 期 27, 页码 2723-2731出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2008.09.004
关键词
Retina; Photoreceptors; Electroretinogram; Diurnal; Rodent
资金
- National Institute for Mental Health [RO1 MH53433]
- Canadian Institutes of Health Research (CIHR) [151145]
- Alberta Heritage Foundation for Medical Research (AHFMR)
- Canadian National Institute for the Blind
- Olive Young Foundation
- The Lena McLaughlin Foundation
- AHFMR summer scholarship (2007)
- INSERM (Institut National de la Sante et de la Recherche Medicale)
- CIHR cooperation program 2006
- Alberta Centre on Aging
- Foundation Fighting Blindness Canada
- NSERC
- University of Calgary
- Barbara Tuck/MacPhee Family Vision Research Award in Macular Degeneration
The most widespread models to study blindness, rats and mice, have retinas containing less than 3% cones. The diurnal rodent Arvicanthis niloticus retina has around 35% cones. Using ERG recordings, we studied retina function in this species. Several features differed from that reported in rats and mice: (a) fivefold larger photopic a-wave amplitudes; (b) photopic hill effect in Nile grass rats only: and (c) flicker amplitude plateau between 5 to 35 Hz with fusion beyond 60 Hz in Nile grass rats only. We conclude that A. niloticus might complement rats and mice for studying retinal function and pathologies involving cones. (C) 2008 Elsevier Ltd. All rights reserved.
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