期刊
VIRUS RESEARCH
卷 161, 期 1, 页码 59-64出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2011.03.015
关键词
Hepatitis E virus; Capsid protein; Crystal structure; Particle assembly
类别
资金
- Foundation for Research Collaboration Center on Emerging and Re-emerging infections
- Research and Development Program for New Bioindustry Initiatives of Bio-oriented Technology Research Advancement Institution (BRAIN)
- Grants-in-Aid for Scientific Research [21390138] Funding Source: KAKEN
Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the particle expressed by recombinant baculovirus or bacteria have been revealed. Based on these reports, the structural features of the HEV capsid subunit and viral particle are reviewed to give insights to the mechanisms underlying the particle assembly, antigenicity, host cell attachment and native virion packaging. (C) 2011 Elsevier B.V. All rights reserved.
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