期刊
VIRUS RESEARCH
卷 160, 期 1-2, 页码 159-165出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2011.06.005
关键词
Innate immunity; Immune evasion; Signaling; Virulence; Leptopilina boulardi; Virus-like particles
类别
资金
- USDA [2006-03817, 2009-35302-05277]
- NIH NIGMS [S06 GM08168, G12-RR03060]
- PSC-CUNY
- Harvard Medical School [P50-GM68762]
Viruses and virus-like particles (VLPs) of insect parasitoids modify host-parasite interactions. The Drosophila wasp, Leptopilina heterotoma, produce 300 nm spiked VLPs that bind to the host's blood cells via surface projections. L. heterotoma is a generalist wasp that attacks over a dozen Drosophila species. Oviposition introduces VLPs into the hemolymph of Drosophila larvae. VLPs lyse hemocytes and obliterate immune signaling in infected larval hosts. L. boulardi, a member of a distinct Leptopilina clade, is a specialist, whose host range is limited to the melanogaster group. As a step toward understanding a potential relationship between venom contents and host range in these wasps, we used electron microscopy to characterize VLPs from the virulent L boulardi-17 (Lb-17) strain. While the Lb-17 VLPs can neither lyse blood cells nor suppress host defense, their biogenesis is surprisingly similar to that of L. heterotoma. Like L heterotoma VLPs, L boulardi VLPs are stellate; but they have fewer spikes, each spike being significantly longer than the spikes in L. heterotoma VLPs. The Lb-17 VLPs possess a dimple, making them clearly distinct from L. heterotoma VLPs. We discuss the significance of these cross-clade differences in VLP morphologies in relation to their biological activities and the host range of the wasp. (C) 2011 Elsevier B.V. All rights reserved.
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