期刊
VIRUS RESEARCH
卷 154, 期 1-2, 页码 98-103出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2010.07.018
关键词
Porcine reproductive and respiratory; syndrome virus; PRRSV; CD163; SRCR domains; Receptor; Review
类别
Porcine reproductive and respiratory syndrome virus (PRRSV) infects fully differentiated cells of the monocyte/macrophage lineage. Recently, CD163 was shown to be a cellular receptor capable of mediating infection of otherwise PRRSV non-permissive cell lines. CD163 is a macrophage differentiation antigen belonging to the scavenger receptor cysteine-rich (SRCR) family of membrane proteins. We provide a brief review of current knowledge regarding CD163 in relation to PRRSV infection, and propose a structure-based prediction of amino acid sequences involved in PRRSV interaction. (C) 2010 Elsevier B.V. All rights reserved.
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