Article
Biotechnology & Applied Microbiology
Lin Liu, Lu-Guang Jiang, Jin-Hong Luo, Ai-Ai Xia, Li-Qun Chen, Yan He
Summary: This study investigated the phenotypic diversity and genetic basis of root hair length in maize using a diverse association panel. Through GWAS analysis, candidate genes related to cellular signaling, polar growth, disease resistance, and metabolic pathways were identified, shedding light on the genetic mechanisms underlying root hair growth in maize.
Article
Biotechnology & Applied Microbiology
Zixue Xuan, Yiwen Zhang, Jinying Jiang, Xiaowei Zheng, Xiaoping Hu, Xiuli Yang, Yanfei Shao, Guobing Zhang, Ping Huang
Summary: This study identified m(6)A-SNPs associated with breast cancer and explored their potential functions. The SNPs rs4829 and rs9610915 were found to potentially be associated with breast cancer due to having eQTL signals, altered gene expression, and proximity to m(6)A modification sites. Further research is needed to clarify how genetic variation affects epigenetic modification and its functions in breast cancer pathogenesis.
Article
Biotechnology & Applied Microbiology
Xiurong Zhao, Changsheng Nie, Jinxin Zhang, Xinghua Li, Tao Zhu, Zi Guan, Yu Chen, Liang Wang, Xue Ze Lv, Weifang Yang, Yaxiong Jia, Zhonghua Ning, Haiying Li, Changqing Qu, Huie Wang, Lujiang Qu
Summary: This study utilized genome-wide association study to identify 148 SNPs associated with egg number traits and 32 candidate genes related to hormone regulation, follicle development, and reproductive system development. The study also highlighted a genomic region on GGA5 as a potential candidate region underlying egg number traits.
Article
Genetics & Heredity
Yongyi Du, Ning Kong, Jibin Zhang
Summary: A study identified 65 new genes associated with AMD using methods such as random walk and support vector machine, and found 45 genes related to AMD, with an overlap of 37 genes. Further research revealed the genetic pathogenic factors and related mechanisms of AMD.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Jung Min Kim, Jae Il Lyu, Dong-Gun Kim, Nguyen Ngoc Hung, Ji Su Seo, Joon-Woo Ahn, You Jin Lim, Seok Hyun Eom, Bo-Keun Ha, Soon-Jae Kwon
Summary: This study used genome-wide association mapping to identify and validate quantitative trait nucleotides (QTNs) related to isoflavone contents in soybean seeds. Several QTNs related to isoflavone contents were detected, and significant differences in the transcript levels of core genes in the isoflavone biosynthetic pathway were found between the original cultivar and its mutant. These findings are important for breeding soybean lines with high and stable concentrations of isoflavones.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Reproductive Biology
Rongrong Ding, Yibin Qiu, Zhanwei Zhuang, Donglin Ruan, Jie Wu, Shenping Zhou, Jian Ye, Lu Cao, Linjun Hong, Zheng Xu, Enqin Zheng, Zicong Li, Zhenfang Wu, Jie Yang
Summary: This study aimed to investigate the genetic basis of litter traits in pigs, identifying valuable genes and genetic markers for pig breeding. Through a genome-wide association study, 76 significantly related SNPs and 10 potential candidate genes were detected, including 13 pleiotropic SNPs that affected multiple litter traits. Functional enrichment analysis indicated that significant pathways were associated with hormone secretion and embryo and organ development, providing new insights into improving litter quality in pigs.
Article
Fisheries
Prapaiphan Chaivichoo, Sila Sukhavachana, Rabuesak Khumthong, Prapansak Srisapoome, Uthairat Na-Nakorn, Satid Chatchaiphan
Summary: This study utilized next-generation sequencing to identify SNPs associated with growth traits in bighead catfish and estimated their genetic parameters using genomic best linear unbiased prediction. The results showed that GBLUP improved the accuracy of EBV estimates and suggested that marker-assisted selection using the identified SNPs may not be promising, while genomic selection based on GEBV is a better approach.
Article
Plant Sciences
Guanglian Liao, Min Zhong, Zhiqiang Jiang, Junjie Tao, Dongfeng Jia, Xueyan Qu, Chunhui Huang, Qing Liu, Xiaobiao Xu
Summary: The study revealed the complex biological characteristics of kiwifruit flowers and leaves through GWAS, identifying key genes associated with these traits. An analysis of 946,337 SNP markers also uncovered the genetic structure of A. eriantha and drew conclusions from it.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ines Medina-Lozano, Aurora Diaz
Summary: Crop breeding has historically focused on improving productivity and resistance to stresses, with less attention given to enhancing nutritional value. However, recent advancements in genetic engineering and conventional methods have allowed for biofortification of crops, resulting in the development of varieties with improved nutrient content. Genomic tools have played a crucial role in this process, facilitating the identification and transfer of desirable traits. Future challenges lie in the regulatory framework and further progress in this emerging field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Chen Jiang, Ronald B. Melles, Jie Yin, Qiao Fan, Xiaobo Guo, Ching-Yu Cheng, Mingguang He, David A. Mackey, Jeremy A. Guggenheim, Caroline Klaver, K. Saidas Nair, Eric Jorgenson, Helene Choquet
Summary: Introduction: Long axial length (AL) is a risk factor for myopia. Although family studies indicate that AL has an important genetic component, there have been few reports of AL-associated loci. This multiethnic GWAS identified 16 genomic loci associated with AL, of which 5 are novel. The study also found genetic correlations between AL, MSE, and myopia risk.
FRONTIERS IN GENETICS
(2023)
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Le Gao, Chengsheng Meng, Tengfei Yi, Ke Xu, Huiwen Cao, Shuhua Zhang, Xueju Yang, Yong Zhao
Summary: The study identified 270 significant SNPs associated with yield- and quality-related traits in wheat, and detected 638 putative candidate genes near these SNPs. This provides new insights into the genetic basis of wheat yield and quality.
Article
Genetics & Heredity
Liming Zhang, Zijian Zhu, Qing Yang, Jingjing Zhao
Summary: This study identified the genetic basis of two subtypes of spatial working memory (SWM) in humans and discovered a candidate genetic locus and gene set associated with SWM. The findings suggest that genetic factors may play a role in the performance of SWM tasks.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Wenwen Wei, Xin Wang, Yuanzhong Zhou, Xuejun Shang, Hongsong Yu
Summary: Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Article
Pharmacology & Pharmacy
Chenxue Mao, Juan Chen, Ting Zou, Yuankang Zhou, Junyan Liu, Xi Li, Xiangping Li, Min Li, Pinhua Pan, Wei Zhuo, Yang Gao, Shuo Hu, Desheng Xiao, Lin Wu, Zhan Wang, Heng Xu, Wen Yang, Yingjie Xu, Haihua Xiao, Kazuhiko Hanada, Wei Zhang, Honghao Zhou, Jiye Yin, Zhaoqian Liu
Summary: This study investigated the pharmacogenomic markers associated with platinum-based chemotherapy response in NSCLC patients through genome-wide association studies and validated the findings in independent cohorts. The results identified two genetic variations (rs2280496 and rs189178649) in the ADCY1 gene that were associated with the sensitivity of platinum-based chemotherapy in NSCLC patients.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.