Article
Infectious Diseases
Elmostafa Benaissa, Elmehdi Belouad, Youness Mechal, Yassine Benlahlou, Mariama Chadli, Adil Maleb, Mostafa Elouennass
Summary: This study aimed to describe the bacterial epidemiology of community urinary tract infections with multidrug-resistant (MDR) bacteria and determine the associated risk factors in our region. The findings showed significant associations between age, sex, urban origin, recent hospitalization, and antibiotic therapy history with MDR community-acquired urinary tract infections, emphasizing the need to review antibiotic prescription practices for better management of these infections.
Review
Infectious Diseases
Susanna Esposito, Giacomo Biasucci, Andrea Pasini, Barbara Predieri, Gianluca Vergine, Antonella Crisafi, Cristina Malaventura, Luca Casadio, Marcello Sella, Luca Pierantoni, Claudia Gatti, Letizia Paglialonga, Chiara Sodini, Claudio La Scola, Luca Bernardi, Giovanni Autore, Giulia Dal Canto, Alberto Argentiero, Sante Cantatore, Martina Ceccoli, Alessandro De Fanti, Agnese Suppiej, Marcello Lanari, Nicola Principi, Andrea Pession, Lorenzo Iughetti
Summary: Febrile urinary tract infection (UTI) is a common and serious bacterial illness in children. Early effective antibiotic treatment is essential, but antibiotic resistance is increasing, making it more difficult to choose the best therapy. Efforts to reduce and rationalize antibiotic consumption, as well as antibiotic stewardship, are important in limiting the emergence of resistance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Pediatrics
Yasmina Dejonckheere, Stefanie Desmet, Noel Knops
Summary: This study retrospectively analyzed the prevalence of uropathogens in hospitalized children with febrile UTIs between 2000 and 2019, and found an increasing trend of antimicrobial resistance in Escherichia coli. This trend was observed not only in children with risk factors, but also in the general population, highlighting a significant problem.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Genetics & Heredity
Hamid Vaez, Hossein Kalarestaghi, Amirhossein Sahebkar, Farzad Khademi
Summary: This study is the first systematic review and meta-analysis to report the prevalence of antibiotic-resistant and ESBL-producing Proteus spp. in UTIs in Iran. The pooled frequency of Proteus spp. isolated from UTIs in Iran was 9.3% and the isolates showed high resistance against ampicillin, piperacillin, cefoxitin, and trimethoprim/sulfamethoxazole. However, they were highly susceptible to levofloxacin and norfloxacin. The prevalence rates of ESBL-producing Proteus spp. and MDR strains were estimated to be 25.8% and 57.9% respectively.
Article
Immunology
Mohamed Kettani Halabi, Fatima Azzahra Lahlou, Idrissa Diawara, Younes El Adouzi, Rabiaa Marnaoui, Rachid Benmessaoud, Imane Smyej
Summary: ESBL-EC infections pose challenges due to limited treatment options, increased hospital costs, reduced microbiological and clinical responses, and a threat to patient's life. Majority of ESBL-EC isolates were from female adult patients over 50, resistant to third-generation cephalosporins and quinolones, but sensitive to carbapenems and fosfomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pediatrics
Giovanni Autore, Cosimo Neglia, Margherita Di Costanzo, Martina Ceccoli, Gianluca Vergine, Claudio La Scola, Cristina Malaventura, Alice Falcioni, Alessandra Iacono, Antonella Crisafi, Lorenzo Iughetti, Maria Luisa Conte, Luca Pierantoni, Claudia Gatti, Giacomo Biasucci, Susanna Esposito
Summary: This study describes the clinical outcomes of discordant empirical treatments in pediatric UTIs and identifies risk factors associated with treatment failure. The study found that discordant empirical treatments may still be effective in more than half of pediatric UTIs, but the clinical effectiveness varies between different antibiotics and patients with risk factors may require a differentiated approach to treatment.
Article
Urology & Nephrology
Nadide Melike Sav, Nuran Cetin, Emel Caliskan, Bilal Yildiz
Summary: Escherichia coli was the main bacterial pathogen in pediatric pyelonephritis, with children having risk factors showing higher antibiotic resistance. Patients under prophylaxis also exhibited higher resistance rates to certain antibiotics. Frequent antibiotic use in recurrent infections may contribute to antibiotic resistance development in children.
TURKISH JOURNAL OF NEPHROLOGY
(2021)
Article
Pharmacology & Pharmacy
S. Samanci, A. S. Pinarbasi
Summary: This study aimed to identify the pathogens causing urinary tract infections (UTIs), assess their antibiotic resistance, and determine the appropriate empirical antibiotic treatment strategy. The results demonstrated a high prevalence of resistance against oral and parenteral antibiotics used in UTI treatment. This highlights the importance of rational antibiotic use.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pediatrics
Davood Kheirkhah, Elahe Ghasemi, Mozhgan Derakhshan, Sareh Bagheri-Josheghani, Hamid Reza Gilasi, Mohammadjavad Azadchehr, Mohammad Reza Sharif
Summary: This study aimed to determine the prevalence of urinary tract pathogens and antibiotic resistance in children with urinary tract infections referred to Shahid Beheshti Kashan Hospital in 2018-2019. The results showed that pediatric urinary tract infections are most likely caused by Escherichia coli and have a high sensitivity to Amikacin, but resistance to Ampicillin.
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD
(2023)
Article
Microbiology
S. J. Ryan Arends, Deborah Butler, Nicole Scangarella-Oman, Mariana Castanheira, Rodrigo E. Mendes
Summary: The in vitro activities of gepotidacin against a large collection of Escherichia coli and Staphylococcus saprophyticus strains, including those resistant to other standard-of-care antibiotics, were determined. Gepotidacin exhibited potent activity, inhibiting the majority of isolates at low concentrations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Giovanni Autore, Luca Bernardi, Filippo Ghidini, Claudio La Scola, Alberto Berardi, Giacomo Biasucci, Federico Marchetti, Andrea Pasini, Maria Elena Capra, Claudia Castellini, Vera Cioni, Sante Cantatore, Andrea Cella, Francesca Cusenza, Alessandro De Fanti, Elisa Della Casa Muttini, Margherita Di Costanzo, Alessandra Dozza, Claudia Gatti, Cristina Malaventura, Luca Pierantoni, Giovanni Parente, Gabriella Pelusi, Serafina Perrone, Laura Serra, Francesco Torcetta, Enrico Valletta, Gianluca Vergine, Francesco Antodaro, Andrea Bergomi, Jennifer Chiarlolanza, Laura Leoni, Franco Mazzini, Roberto Sacchetti, Agnese Suppiej, Lorenzo Iughetti, Andrea Pession, Mario Lima, Susanna Esposito
Summary: Low-dose continuous antibiotic prophylaxis (CAP) is commonly used to prevent urinary tract infections (UTIs) in children, but its efficacy is controversial. This systematic review found that CAP has a limited role in preventing UTI recurrences and complications in children, while also posing a risk of emerging antimicrobial resistances.
Article
Pediatrics
Mohammed A. Alsubaie, Abdullah Z. Alsuheili, Mohammed N. Aljehani, Abdulrahman A. Alothman, Abdulaziz S. Alzahrani, Hamza A. Mohammedfadel, Abeer A. Alnajjar
Summary: This study evaluated demographics, clinical characteristics, risk factors, and antibiotic resistance of pediatric community-acquired UTIs caused by ESBL-producing and non-ESBL-producing uropathogens. It was found that renal abnormalities and male gender were independent risk factors for ESBL UTIs.
PEDIATRICS INTERNATIONAL
(2023)
Article
Infectious Diseases
Adi Turjeman, Tanya Babich, Miquel Pujol, Jordi Carratala, Evelyn Shaw, Aina Gomila-Grange, Cuong Vuong, Ibironke Addy, Irith Wiegand, Sally Grier, Alasdair MacGowan, Christiane Vank, Nienke Cuperus, Leo van den Heuvel, Leonard Leibovici, Noa Eliakim-Raz
Summary: The study aimed to identify risk factors for enterococcal urinary tract infection in patients with complicated UTI, finding that male gender, age range of 55-75 years, catheter-associated UTI, and urinary retention were associated risk factors for enterococcal UTI.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Ali Mahmoudi, Mohsen Moghadami, Babak Shirazi, Parinaz Tabari, Mahsa Moosavi
Summary: The study conducted at Shiraz University Laboratory analyzed urine cultures and found Escherichia coli to be the predominant isolate with high resistance rates to trimethoprim-sulfamethoxazole, ceftriaxone, and ciprofloxacin. It recommends using nitrofurantoin and aminoglycosides as appropriate empirical treatments for UTIs before culture results are available due to their high sensitivity rates.
ADVANCED BIOMEDICAL RESEARCH
(2021)
Review
Urology & Nephrology
Ursula Lemberger, Fahad Quhal, Andreas Bruchbacher, Shahrokh F. Shariat, Manuela Hiess
Summary: UTI is a common pediatric infection that can be accurately diagnosed and treated using 16S rRNA sequencing technology to identify bacteria species. Changes in bacterial composition and pH levels in urine can be correlated with UTI, prompting the need for precise therapeutic decisions and prevention of antibiotic resistance. Understanding the distinct urogenital microbiome in children can help develop new treatment approaches and prevent long-term dysbiosis.
CURRENT OPINION IN UROLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Soha Ghanem, Sara Hassan, Randa Saad, Ghassan S. Dbaibo
EXPERT OPINION ON BIOLOGICAL THERAPY
(2013)
Article
Endocrinology & Metabolism
Randa Saad, Maya Beydoun, Ghada El-Hajj Fuleihan
JOURNAL OF CLINICAL DENSITOMETRY
(2020)
Review
Endocrinology & Metabolism
Aya Bassatne, Marlene Chakhtoura, Randa Saad, Ghada El-Hajj Fuleihan
METABOLISM-CLINICAL AND EXPERIMENTAL
(2019)
Article
Endocrinology & Metabolism
Randa K. Saad, Hilda Harb, Ibrahim R. Bou-Orm, Walid Ammar, Ghada El-Hajj Fuleihan
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Review
Endocrinology & Metabolism
Randa Saad, Dalal Habli, Rawaa El Sabbagh, Marlene Chakhtoura
JOURNAL OF CLINICAL DENSITOMETRY
(2020)
Article
Endocrinology & Metabolism
R. K. Saad, N. G. Boueiz, V. C. Akiki, G. A. E. -H. Fuleihan
OSTEOPOROSIS INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Randa K. Saad, Vanessa C. Akiki, Maya Rahme, Sara Ajjour, Mariam Assaad, Ghada A. El-Hajj Fuleihan
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Public, Environmental & Occupational Health
Randa K. Saad, Mohannad Al Nsour, Yousef Khader, Magid Al Gunaid
Summary: This study quantifies the literature on public health surveillance in the Eastern Mediterranean Region (EMR) over the past decade, revealing trends in research productivity and themes. Iran emerged as a leading country in publishing relevant research, with topics like COVID-19 and SARS-CoV-2 being prominent in recent surveillance studies. The findings also highlight gaps in surveillance research in the EMR, particularly in noncommunicable diseases and injury-related surveillance.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Medicine, Research & Experimental
Randa K. Saad, Sara Abu Khudair, Maha El Rabbat, Mayeh Omar, Mohannad Al Nsour, Yousef Khader, Salman Rawaf
Summary: This study aims to provide an overview of the publication activities and trends in COVID-19 research in the Eastern Mediterranean Region (EMR). The study found that Iran and Saudi Arabia were the most active countries in COVID-19 research in the region, and international collaboration was limited. Recent research topics included vaccines, machine learning, and online learning.
INTERACTIVE JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Randa K. Saad, Adna Maiteh, Rima Nakkash, Ramzi G. Salloum, Ali Chalak, Niveen M. E. Abu-Rmeileh, Yousef Khader, Mohannad Al Nsour
Summary: Waterpipe tobacco smoking (WTS) is a traditional tobacco use method that is highly prevalent in the Eastern Mediterranean Region (EMR). Despite its documented harm, there is a lack of global regulatory response to the growing prevalence of WTS, especially among youth. Effective tobacco control strategies tailored to WTS are urgently needed, and taxation, volumetric choice experiments, and global surveillance systems such as GTSS can play important roles in combating WTS.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Medicine, Research & Experimental
Rana AlHamawi, Randa K. Saad, Hanan F. Abdul Rahim, Khwaja Mir Islam Saeed, Abdullatif Husseini, Yousef Khader, Mohannad Al Nsour
Summary: Public health research in the Eastern Mediterranean Region (EMR) is below the global average and lacks growth over time. Challenges and barriers to research, including lack of strategic prioritization and funding, were identified. Collaboration involving institutions and policymakers is critical to improve research resilience and public health care in the region.
INTERACTIVE JOURNAL OF MEDICAL RESEARCH
(2023)