Article
Biochemistry & Molecular Biology
Peerapat Khamwachirapithak, David Guillaume-Schoepfer, Pakkanan Chansongkrow, Sarah A. Teichmann, Philip A. Wigge, Varodom Charoensawan
Summary: This study combines ChIP-seq and RNA-seq to investigate the effects of global and local H3 depletion on gene transcription, as well as the interaction between the transcription factor Rap1 and H3. The results provide a working model and testable hypotheses regarding the impact of H3 depletion on transcriptional changes.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Article
Biochemistry & Molecular Biology
Yanjie Kong, Wenlong Ren, Huan Fang, Naseer Ali Shah, Yujie Shi, Dingyun You, Chengang Zhou, Dewei Jiang, Chuanyu Yang, Huichun Liang, Wenjin Liu, Luzhen Wang, Wenqiang Gan, Xing Wan, Fubing Li, Zhen Li, Ceshi Chen, Ni Xie
Summary: This study reveals a novel mechanism by which histone deacetylase inhibitors suppress basal-like breast cancer (BLBC) by promoting proteasomal degradation of KLF5 protein through ubiquitination. The acetylation of KLF5 at lysine 369 decreases its binding with deubiquitinase BAP1, leading to decreased BLBC cell viability and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Ienglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D. Pagani, Ashraf Abou El Ela, Jordan S. Pober, Bertram Pitt, Jeffrey L. Platt, Marilia Cascalho, Zhong Wang, Y. Eugene Chen, Richard M. Mortensen, Paul C. Tang
Summary: Preservation quality is crucial for successful heart transplantation, and prolonged preservation can lead to graft dysfunction. However, geographical limitations and transport time constraints limit donor heart utilization. This study demonstrates that metabolic reprogramming through up-regulation of the IRG1 gene and itaconate improves heart function after prolonged preservation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Mohamed A. Hamid, M. Tarek Moustafa, Sonali Nashine, Rodrigo Donato Costa, Kevin Schneider, Shari R. Atilano, Baruch D. Kuppermann, M. Cristina Kenney
Summary: Our study indicates that anti-VEGF drugs can affect the expression of genes related to oxidative stress, inflammation, and apoptosis, while TSA-induced deacetylation can alter transcription of genes involved in angiogenesis, apoptosis, and inflammation.
Article
Plant Sciences
Konstantin O. Kutashev, Michal Franek, Klev Diamanti, Jan Komorowski, Marie Olsinova, Martina Dvorackova
Summary: Arabidopsis thaliana's 45S ribosomal genes are located on the termini of chromosomes 2 and 4, encoding rRNA. Not all intranucleolar rDNA is active, with some forming condensed foci marked with repressive histone marks. The condensed foci relate to rDNA folding and contain typical modifications of inactive rDNA.
Article
Multidisciplinary Sciences
Frederik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlene Carney, Florine Bornaque, Emilie Courty, Celine Gheeraert, Jerome Eeckhoute, David Dombrowicz, Julie Kerr-Conte, Francois Pattou, Bart Staels, Philippe Froguel, Amelie Bonneford, Jean-Sebastien Annicotte
Summary: Histone deacetylase enzymes (HDACs) regulate gene expression by deacetylating specific histone and non-histone proteins. In this study, the researchers investigated the role of HDACs in maintaining the identity and function of insulin-producing beta cells in the pancreas. They found that HDAC inhibition altered the transcriptional program of beta cells and could lead to loss of their identity.
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)
Article
Agronomy
Sasipriya Sasikumar, Banur Marulasiddappa Dushyanthakumar, Shankarappa Sridhara, Nagarajappa Adivappar, Harish Babu Bheemanapalli Nagraja, Ahmed M. El-Shehawi, Salman Aloufi, Mohammed Alqurashi, Hosam O. Elansary, Khalid M. Elhindi, Eman A. Mahmoud
Summary: This study investigated the effects of Trichostatin A (TSA) on the morphological variations in okra. The results showed that TSA treatment had a negative impact on the growth and development of okra, including inhibited seedling emergence, malformed plants, abnormal flower development, and pollen sterility. However, under specific doses and incubation periods, TSA treatment can induce epigenetic variations in okra without significantly compromising its growth and vigor parameters.
Article
Biochemistry & Molecular Biology
Julian Broche, Goran Kungulovski, Pavel Bashtrykov, Philipp Rathert, Albert Jeltsch
Summary: This study revealed that DNA methylation introduced in CGIs can significantly decrease gene expression, and is associated with a global decrease in H3K4me3 and H3K27ac, while being stable at some CGIs. The results highlight the importance of genome-wide molecular processes that protect CGIs against DNA methylation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Virology
Gary Z. Wang, Stephen P. Goff
Summary: This study reveals the essential role of p12 protein in tethering viral DNA to host chromatin to allow loading of histones onto the viral DNA. Mutants lacking tethering activity fail to acquire histones, retain capsid and nucleocapsid proteins, and are poorly transcribed, defining a new requirement for a viral protein in chromatinization of viral DNA.
JOURNAL OF VIROLOGY
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Orthopedics
H. S. Hwang, I. Y. Park, J. I. Hong, J. R. Kim, H. A. Kim
Summary: This study found that joint damage develops similarly in both male and female mice after DMM, but the damage progresses less in females. There were subtle sex differences in pain behaviors and the analgesic efficacy of a TRPV1 antagonist, accompanied by a differential regulation of TPRV1.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Menuka Karki, Rahul K. Jangid, Ramakrishnan Anish, Riyad N. H. Seervai, Jean-Philippe Bertocchio, Takashi Hotta, Pavlos Msaouel, Sung Yun Jung, Sandra L. Grimm, Cristian Coarfa, Bernard E. Weissman, Ryoma Ohi, Kristen J. Verhey, H. Courtney Hodges, Warren Burggren, Ruhee Dere, In Young Park, B. V. Venkataram Prasad, W. Kimryn Rathmell, Cheryl L. Walker, Durga N. Tripathi
Summary: The study demonstrates that the coordinated read-write activity of the epigenetic machinery involves the cytoskeleton, with PBRM1 regulating mitosis by binding microtubule methyl marks written by SETD2. This activity is crucial for normal mitosis, and disruptions can lead to genomic instability.
Article
Medicine, General & Internal
Won-Seok Jang, Soo-Hwan Byun, Seoung-Won Cho, In-Young Park, Sang-Min Yi, Jong-Cheol Kim, Byoung-Eun Yang
Summary: Early screw removal may be an effective treatment option for patients with occlusal discrepancies after Orthognathic surgery, as it can help restore temporomandibular joint spaces and alleviate joint problems.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Social Work
In Young Park, Anamika Barman-Adhikari, Hsun-Ta Hsu, Sarah C. Narendorf, Diane Santa Maria, Jama Shelton, Kristin M. Ferguson, Kimberly Bender, Robin Petering
Summary: This study found that discrimination was significantly related to perceived stress among YAEH, and online health information-seeking behavior played a moderating role in this relationship. Therefore, providing digital access and creating online informational resources are important engagement strategies for YAEH.
JOURNAL OF TECHNOLOGY IN HUMAN SERVICES
(2022)
Article
Instruments & Instrumentation
Joo-Hee Lee, Soo-Hwan Byun, Sang-Min Yi, In-Young Park, Byoung-Eun Yang, Hye-Lim Lee
Summary: This study aimed to evaluate the potential for improving dentition imaging with CBCT scans using an intraoral scanner instead of a plaster model. The results showed that the intraoral scanners satisfactorily complemented the CBCT, especially for patients and surgeons who have difficulty in scanning the complete arch at once.
Article
Biology
You Na Lim, Byoung-Eun Yang, Soo-Hwan Byun, Sang-Min Yi, Sung-Woon On, In-Young Park
Summary: This study investigated the relationship between skeletal and soft tissue changes after incisor retraction in patients with Angle Class I bimaxillary dentoalveolar protrusion. The results showed a significant correlation between skeletal point A and soft tissue point A on the anteroposterior axis. However, changes in incisor tip, apex, and inclination did not significantly affect the position of skeletal points A and B. It is important to consider both hard and soft tissue analysis in treatment planning for malocclusion.
Article
Family Studies
In Young Park, Rachel Speer, Darren L. Whitfield, Leo Kattari, Eugene N. Walls, Candace Christensen
Summary: Using multivariate logistic regression, this study analyzed data from the 2015 Healthy Kids Colorado Survey to explore the relationship between the intersection of race/ethnicity and gender identity with mental and behavioral health-related risks. The findings suggest that youth with multiple marginalized identities, particularly those who identify as both Bi/Multi-racial or Latino and as transgender/non-binary, have higher levels of depression and suicidal ideation compared to cisgender White youth. Intersectional approaches are important in designing risk prevention and response interventions for racial/ethnic minority youth who are also transgender/non-binary.
CHILDREN AND YOUTH SERVICES REVIEW
(2022)
Article
Multidisciplinary Sciences
Eun-Ji Chung, Byoung-Eun Yang, In-Young Park, Sangmin Yi, Sung-Woon On, Young-Hee Kim, Sam-Hee Kang, Soo-Hwan Byun
Summary: Lateral cephalograms and related analysis are representative methods for orthodontic treatment, but inaccuracies may be produced when quantitative evaluation is required. Cone-beam computed tomography (CBCT) provides high-resolution three-dimensional images at a relatively low dose and cost, and using artificial intelligence analysis programs for lateral cephalogram generation from CBCT has proven to be efficient and consistent for orthodontic diagnosis and planning.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Sung-Woon On, Sang-Min Yi, In-Young Park, Soo-Hwan Byun, Byoung-Eun Yang
Summary: The aim of this study was to compare the mechanical behaviors of three dental implant fixtures with different abutment connection designs. The results of the static compression to fracture tests and fatigue tests showed that all three implants had suitable mechanical properties for intraoral use. Fracture patterns may vary due to differences in the fixture design or abutment connection.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Family Studies
Jangmin Kim, Jin Yao Kwan, Stephanie Rachel Speer, In Young Park, Jennifer L. Bellamy, Aaron Banman, Justin S. Harty, Neil B. Guterman
Summary: This study examines the influence of parental characteristics on parent-worker relationships in home visiting, finding that immigrant status is an important predictor for both mothers and fathers, while ethnicity is only significant for fathers. Additionally, the study reveals that U.S.-born Hispanic/Latinx fathers face greater challenges in building positive worker relationships. These findings underscore the importance of developing gender-specific and culturally responsive strategies to enhance parent-worker relationships.
FAMILIES IN SOCIETY-THE JOURNAL OF CONTEMPORARY SOCIAL SERVICES
(2023)
Article
Biotechnology & Applied Microbiology
Ran-Yeong Cho, Soo-Hwan Byun, Sang-Min Yi, Hee-Ju Ahn, Yoo-Sung Nam, In-Young Park, Sung-Woon On, Jong-Cheol Kim, Byoung-Eun Yang
Summary: Comparative analysis of facial images obtained from three different facial scanners showed that all scanners achieved acceptable results, with scanner 3 performing the best. Each scanner had its own strengths and weaknesses due to differences in scanning methods. The findings from this study can be utilized in creating digital twins, selecting and merging data, and developing new scanners to overcome limitations.
BIOENGINEERING-BASEL
(2023)
Article
Family Studies
Pari Shah Thibodeau, In Young Park, Annie Zean Dunbar, Amy He
Summary: A positive organizational culture, including a supportive learning culture, is crucial for a healthy child welfare workforce. This study explores the relationship between preparation and training, ongoing professional development, and learning culture among child welfare caseworkers. The findings indicate that preparation for work and professional development are positively associated with learning culture, highlighting the importance of providing relevant opportunities for growth within child welfare settings. The implications for child welfare education, training, and practice applications are discussed.
CHILDREN AND YOUTH SERVICES REVIEW
(2023)
Article
Social Work
In Young Park, N. Eugene Walls, Brittanie Atteberry-Ash, Leo Kattari
Summary: This study examines the relationships between school bullying, online bullying, and suicide attempts among young adults, and the protective role of supportive adults. Results show that both types of bullying are associated with suicide attempts, and only parental support moderates this relationship.
JOURNAL OF THE SOCIETY FOR SOCIAL WORK AND RESEARCH
(2023)
Meeting Abstract
Oncology
Y. -C. Kim, I. -J. Oh, C. -K. Park, H. -J. Oh, I. Y. Park, S. -C. Bae
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Psychology, Clinical
Johnny S. Kim, Jody Brook, Kiley W. Liming, In Young Park, Becci A. Akin, Cynthia Franklin
Summary: This study examines whether parents involved in the child welfare system, due to substance abuse, who receive solution-focused brief therapy (SFBT) counseling experience more hope and positive emotions than those receiving treatment-as-usual counseling services. The results suggest that SFBT may help increase positive emotions and hope in parents through a solution-building approach, but more research is needed.
INTERNATIONAL JOURNAL OF SYSTEMIC THERAPY
(2022)
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.
