Review
Virology
Sylvie Lecollinet, Stephane Pronost, Muriel Coulpier, Cecile Beck, Gaelle Gonzalez, Agnes Leblond, Pierre Tritz
Article
Multidisciplinary Sciences
Gulibositan Aji, Yu Huang, Mei Li Ng, Wei Wang, Tian Lan, Min Li, Yufei Li, Qi Chen, Rui Li, Sishan Yan, Collin Tran, James G. Burchfield, Timothy A. Couttas, Jinbiao Chen, Long Hoa Chung, Da Liu, Carol Wadham, Philip J. Hogg, Xin Gao, Mathew A. Vadas, Jennifer R. Gamble, Anthony S. Don, Pu Xia, Yanfei Qi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Biochemistry & Molecular Biology
Lise Fiacre, Nonito Pages, Emmanuel Albina, Jennifer Richardson, Sylvie Lecollinet, Gaelle Gonzalez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Virology
Camille Victoire Migne, Cecile Beck, Gaelle Gonzalez, Sylvie Lecollinet, Sara Moutailler
Summary: Arboviruses, transmitted by hematophagous arthropods, have significant economic and public health impacts. These viruses possess great adaptive capacities allowing them to emerge in new geographic areas and cross species barriers. Monitoring of arboviruses has evolved considerably over the decades due to innovations in detection technologies.
Article
Medicine, Research & Experimental
James W. Dear, Mei Li Ng, D. Nicholas Bateman, Pakkiri Leroy Sivappiragasam, Hyungwon Choi, Bing Jie Khoo, Baharudin Ibrahim, Chester Lee Drum
Summary: The study showed that patients treated with the 12-hour modified NAC regimen had a significantly higher elevation in plasma NAC and cysteine concentrations at 12 hours post-infusion. However, there were no significant differences in the metabolism of APAP, mitochondrial function, amino acids, and other thiol biomarkers between the two regimens. Additionally, plasma APAP and purine metabolites at baseline may serve as useful biomarkers for early prediction of APAP-induced ALI.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mohammed Ahmed Akkaif, Nur Aizati Athirah Daud, Abubakar Sha'aban, Mei Li Ng, Muhamad Ali Sk Abdul Kader, Dzul Azri Mohamed Noor, Baharudin Ibrahim
Summary: Clopidogrel is a widely-used antiplatelet drug for treating and preventing coronary heart disease, but some patients may experience drug resistance. Genetic polymorphisms, especially CYP2C19 alleles, in the Asian population can affect the efficacy of clopidogrel and appropriate strategies are needed to overcome drug resistance.
Review
Pharmacology & Pharmacy
Mohammed Ahmed Akkaif, Mei Li Ng, Muhamad Ali Sk Abdul Kader, Nur Aizati Athirah Daud, Abubakar Sha'aban, Baharudin Ibrahim
Summary: Ticagrelor inhibits adenosine uptake into cells through ENT1, which increases adenosine concentration in the blood, subsequently enhancing protection of the heart muscle, preventing platelet aggregation, and extending biological effects of coronary arteries. It also leads to a lower mortality rate in patients with acute coronary syndrome (ACS).
PHARMACOLOGICAL REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Catherine Hennechart-Collette, Gaelle Gonzalez, Lisa Fourniol, Audrey Fraisse, Cecile Beck, Sara Moutailler, Laure Bournez, Nolwenn M. Dheilly, Sandrine A. Lacour, Sylvie Lecollinet, Sandra Martin-Latil, Sylvie Perelle
Summary: A molecular method based on the international standard was developed to detect TBEV in raw milk products. The recovery rates of TBEV varied under different inoculation levels and conditions. The sensitivity and reliability of the method were confirmed, making it suitable for routine diagnosis and assessment of potential health risks.
Article
Microbiology
Gaelle Gonzalez, Laure Bournez, Rayane Amaral Moraes, Dumarest Marine, Clemence Galon, Fabien Vorimore, Maxime Cochin, Antoine Nougairede, Catherine Hennechart-Collette, Sylvie Perelle, Isabelle Leparc-Goffart, Guillaume Andre Durand, Gilda Grard, Thomas Benet, Nathalie Danjou, Martine Blanchin, Sandrine A. Lacour, Boue Franck, Guillaume Chenut, Catherine Mainguet, Catherine Simon, Laurence Bremont, Stephan Zientara, Sara Moutailler, Sandra Martin-Latil, Nolwenn M. Dheilly, Cecile Beck, Sylvie Lecollinet
Summary: The geographic range and incidence of tick-borne encephalitis virus (TBEV) are expanding in Europe, posing a risk of outbreaks in non-endemic regions. An outbreak of TBE occurred in Ain, Eastern France in 2020, with all but one patient consuming unpasteurized raw goat cheese. An investigation using a One Health approach confirmed the alimentary origin of the outbreak, identified a risk area for TBEV exposure, and obtained the first TBEV isolate transmitted through food in France.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Farouk Laabassi, Nolwenn Dheilly, Cecile Beck, Rayane Amaral, Gaelle Gonzalez, Delphine Gaudaire, Anthony Madeline, Fanny Lecouturier, Sylvie Lecollinet, Stephan Zientara, Aymeric Hans, Jose-Carlos Valle-Casuso
Summary: To determine the prevalence of EIAV, USUV, and WNV in eastern Algerian drylands, 340 equids' sera were collected from 2015 to 2017. Serological analysis using ELISAs and VNT indicated a 11.47% prevalence of WNV antibodies and no EIAV antibodies. WNV and possibly USUV are circulating in the Algerian equine population, while EIAV seems to be absent.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Virology
Lise Fiacre, Steeve Lowenski, Celine Bahuon, Marine Dumarest, Benedicte Lambrecht, Maha Dridi, Emmanuel Albina, Jennifer Richardson, Stephan Zientara, Miguel-Angel Jimenez-Clavero, Nathalie Pardigon, Gaelle Gonzalez, Sylvie Lecollinet
Summary: West Nile virus (WNV) amplifies in birds and is transmitted to humans and horses through mosquitoes. The virulence of WNV has been studied mainly in mammalian models, but data in avian models are still lacking.
Article
Virology
Claude Saegerman, Marie-France Humblet, Marc Leandri, Gaelle Gonzalez, Paul Heyman, Hein Sprong, Monique L'Hostis, Sara Moutailler, Sarah I. Bonnet, Nadia Haddad, Nathalie Boulanger, Stephen Leib, Thierry Hoch, Etienne Thiry, Laure Bournez, Jana Kerlik, Aurelie Velay, Solveig Jore, Elsa Jourdain, Emmanuelle Gilot-Fromont, Katharina Brugger, Julia Geller, Marie Studahl, Natasa Knap, Tatjana Avsic-Zupanc, Daniel P. Ruzek, Tizza Zomer, Rene Bodker, Thomas F. H. Berger, Sandra Martin-Latil, Nick De Regge, Alice A. Raffetin, Sandrine Lacour, Matthias Klein, Tinne Lernout, Elsa Quillery, Zdenek Hubalek, Francisco Ruiz-Fons, Agustin Estrada-Pena, Philippe Fravalo, Pauline Kooh, Florence Etore, Celine M. Gossner, Bethan Purse
Summary: Tick-borne encephalitis (TBE) is an endemic viral disease in Eurasia, primarily transmitted to humans through ticks and occasionally through unpasteurized milk products. The European Centre for Disease Prevention and Control has reported an increase in TBE incidence over the years, as well as its emergence in new areas. Through expert knowledge elicitation, we identified nine key drivers for TBE emergence and increased incidence, including changes in human behavior, eating habits, landscape, humidity, difficulty in controlling reservoirs and vectors, temperature, wildlife compartments, increase in autochthonous wild mammals, and distribution of tick species vectors.
Article
Microbiology
Baptiste Defaye, Sara Moutailler, Benjamin Vollot, Clemence Galon, Gaelle Gonzalez, Rayane Amaral Moraes, Antoine-Simon Leoncini, Amalia Rataud, Gilles Le Guillou, Vanina Pasqualini, Yann Quilichini
Summary: In this study, blood samples and hematophagous ectoparasites were collected from migratory and sedentary bird populations in Corsican wetlands. Five pathogens, including Trypanosoma sp. in louse flies and Anaplasma phagocytophilum, Erhlichia chaffeensis, and Rickettsia helvetica in ticks, were detected. Additionally, Ehrlichia chaffeensis and the West Nile virus were detected in bird blood samples in Corsica. This is the first report of these tick, louse fly, and pathogen species isolated on the bird population in Corsica, highlighting the importance of bird populations in the presence of arthropod-borne pathogens in Corsican wetlands.
Article
Infectious Diseases
Jowita S. Niczyporuk, Wojciech Kozdrun, Agnieszka Czujkowska, Yannick Blanchard, Mariteragi Helle, Nolwenn M. Dheilly, Gaelle Gonzalez
Summary: The summer temperatures in Poland in 2022 were unusually high, along with above-average rainfall, creating a climate that resembled the tropics. These conditions were ideal for the spread of vector-borne zoonotic diseases, including West Nile fever. In the Mazowieckie region of northeastern Poland, an increase in the number of deaths among wild hooded crows was reported, and it was found that the cause of death was the West Nile virus lineage 2. This study detected WNV in 17 out of 99 free-living birds tested, all collected from the same area.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Mohammed Ahmed Akkaif, Abubakar Sha'aban, Nur Aizati Athirah Daud, Ismaeel Yunusa, Mei Li Ng, Muhamad Ali Sk Abdul Kader, Dzul Azri Mohamed Noor, Baharudin Ibrahim
Summary: Comparing ticagrelor with clopidogrel in elderly patients with coronary heart disease did not show significant differences in major adverse cardiovascular events, myocardial infarction, stent thrombosis, all-cause death, and major bleeding events.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)