Article
Gastroenterology & Hepatology
Joshua Kwon, Daniela Fluxa, Francis A. Farraye, Paul T. Kroner
Summary: The study found a significant association between IBD and CMV colitis, with a higher occurrence rate in patients with UC. Patients with CD and CMV colitis had increased odds of mortality, shock, and ICU stay, while patients with UC had a higher likelihood of undergoing colectomy. Patients with IBD and CMV colitis also experienced higher odds of acute kidney injury, multiorgan failure, increased hospital costs, and longer hospital stays compared to those without CMV colitis. Prospectively designed studies are needed to further investigate the risk factors and impact of CMV colitis on IBD patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Review
Infectious Diseases
Keyu Ren, Chunming Yong, Yanting Wang, Hongyun Wei, Kun Zhao, Baoguo He, Mingjuan Cui, Yunqing Chen, Jin Wang
Summary: The objective of this review was to explore the association between CMVP and immunosuppressive therapy in IBD patients, and to emphasize the significance of CMV as an opportunistic pathogen and its potential impact on morbidity and mortality. Records and clinical trajectories related to CMVP in IBD patients were retrieved from the PubMed database, with no language barriers. Our findings showed that CMVP primarily occurs during Crohn's disease remission and azathioprine is the main immunosuppressant linked to CMV reactivation. Prompt antiviral therapy can greatly improve patient outcomes, and CMV vaccine might serve as a potential prevention strategy.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Medicine, General & Internal
Robert B. Gilmore, Kirstin M. Taylor, C. Orla Morrissey, Bradley J. Gardiner
Summary: This article reviews the available literature and outlines a practical approach to the diagnosis and management of cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD).
INTERNAL MEDICINE JOURNAL
(2022)
Article
Medicine, General & Internal
Wei-Sheng Chung, Sunny Chung, Chung-Y Hsu, Cheng-Li Lin
Summary: The study suggests that regardless of the presence of appendicitis, appendectomy increases the risks of ulcerative colitis and Crohn's disease.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili
Summary: In this prospective study, it was found that dietary and lifestyle risk factors for inflammatory bowel disease may differ according to disease phenotype.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kristine H. Allin, Rikke K. Jacobsen, Ryan C. Ungaro, Jean-Frederic Colombel, Alexander Egeberg, Marie Villumsen, Tine Jess
Summary: This study found that bariatric surgery is associated with an increased risk of new-onset Crohn's disease, particularly in women, but not ulcerative colitis. The underlying mechanisms remain unclear.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Xiaoding Shen, Qianyi Wan, Rui Zhao, Yutao Wu, Yong Wang, Yaping Cui, Xiangnan Su, Xiaoting Wu
Summary: The umbrella review of 25 meta-analyses found that patients with inflammatory bowel diseases had a higher risk of adverse health outcomes in various aspects, but the quality of evidence was generally low. More research is needed to draw firmer conclusions.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Immunology
Wen Cheng, Yang Liao, Ruiyu Mou, Xian Xiao, Yingjie Jia
Summary: Using mendelian randomization (MR) analysis, this study finds no causal association between inflammatory bowel disease (IBD) and prostate cancer (PCa), contradicting most observational studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biology
Alina Ecaterina Jucan, Otilia Gavrilescu, Mihaela Dranga, Iolanda Valentina Popa, Bogdan Mircea Mihai, Cristina Cijevschi Prelipcean, Catalina Mihai
Summary: New research suggests a possible link between inflammatory bowel disease (IBD) and an increased risk of ischemic heart disease (IHD). The disruption of the intestinal mucosal barrier in IBD may lead to the translocation of endotoxins into the bloodstream, triggering a pro-inflammatory response that can contribute to endothelial dysfunction, atherosclerosis, and acute cardiovascular events. It is crucial to monitor and manage cardiovascular risk factors in IBD patients, and optimize therapy during active flares. Further studies, biomarkers, and scoring systems are needed for optimal management of IHD risk in IBD patients.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Infectious Diseases
Fengming Yi, Meifang Huang
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2013)
Review
Biotechnology & Applied Microbiology
Yi Fengming, Wu Jianbing
Article
Medicine, General & Internal
Fengming Yi, Liuqing Ge, Jie Zhao, Yuan Lei, Feng Zhou, Zhifen Chen, Youqing Zhu, Bing Xia
Article
Cell Biology
Lu Song, Rui Zhou, Sha Huang, Feng Zhou, Shufang Xu, Wei Wang, Fengming Yi, Xiaobing Wang, Bing Xia
MEDIATORS OF INFLAMMATION
(2013)
Article
Chemistry, Multidisciplinary
Changgao Wang, Shufang Xu, Fengming Yi, Xiaobing Wang, Yuan Lei, Sha Huang, Rui Zhou, Bing Xia
PHARMACEUTICAL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Qiao Yu, Siying Zhu, Rui Zhou, Fengming Yi, Yuntao Bing, Sha Huang, Zixi Wang, Chunyu Wang, Bing Xia
Article
Medicine, Research & Experimental
Fengming Yi, Longxiang Xin, Long Feng
Summary: Numerous circRNAs are dysregulated in cholangiocarcinoma (CCA), with circRNA_000585 being upregulated and potentially functioning through a circRNA_000585/miR-615-5p/AMOT/YAP pathway, which may represent a novel CCA pathway.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Long Feng, Jinfeng Luo, Fengming Yi
Summary: The study found significantly higher expression of DOG1 mRNA in PBCs of GIST patients, with high specificity and sensitivity, indicating DOG1 may be an ideal biomarker for GIST. Clinical factors correlated with DOG1 expression include tumor diameter and risk of aggressive behavior.
ARAB JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Wei Yu, Qiaomeng Tao, Yufeng Zhang, Fengming Yi, Long Feng
Summary: The study found that regorafenib combined with toripalimab has a promising effect in the third-line and beyond treatment of advanced colorectal cancer, with surgical resection of primary lesions potentially having a positive impact on this combination therapy. The treatment-related adverse reactions in combined therapy are tolerable to a certain extent.
JOURNAL OF ONCOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Fengming Yi, Min Chen, Bing Xia
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2012)