期刊
VIROLOGY JOURNAL
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1743-422X-8-242
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资金
- Natural Sciences and Engineering Research Council of Canada
- Egyptian Ministry of Higher Education
- SENTINEL Bioactive Paper Network
Background: Lytic bacteriophages have been applied successfully to control the growth of various foodborne pathogens. Sequencing of their genomes is considered as an important preliminary step to ensure their safety prior to food applications. Results: The lytic bacteriophage, Phi SboM-AG3, targets the important foodborne pathogen, Shigella. It is morphologically similar to phage ViI of Salmonella enterica serovar Typhi and a series of phages of Acinetobacter calcoaceticus and Rhizobium meliloti. The complete genome of Phi SboM-AG3 was determined to be 158 kb and was terminally redundant and circularly permuted. Two hundred and sixteen open reading frames (ORFs) were identified and annotated, most of which displayed homology to proteins of Salmonella phage ViI. The genome also included four genes specifying tRNAs. Conclusions: This is the first time that a Vi-specific phage for Shigella has been described. There is no evidence for the presence of virulence and lysogeny-associated genes. In conclusion, the genome analysis of Phi SboM-AG3 indicates that this phage can be safely used for biocontrol purposes.
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