Article
Agriculture, Dairy & Animal Science
Joanna Pajdak-Czaus, Patrycja Schulz, Elibieta Terech-Majewska, Wojciech Szweda, Andrzej Krzysztof Siwicki, Aleksandra Platt-Samoraj
Summary: The study found that IPNV infection may lead to secondary bacterial infections, affecting non-specific immunity. The influence of pathogens on non-specific immunity depends on the time between infections.
Article
Gastroenterology & Hepatology
Sungil Jang, Lori M. Hansen, Hanfu Su, Jay Solnick, Jeong-Heon Cha
Summary: This study found that the number of cagA copies in Helicobacter pylori is higher in mice with less intense immune response and lower in mice with more intense immune response. Additionally, cagY recombination is also associated with H. pylori virulence.
Article
Fisheries
Cuneyt Tamer, Hakan Isidan, Gulnur Kalayci, Emre Ozan, Buket Ozkan, Harun Albayrak
Summary: This study analyzed the VP2 gene of recent IPNV isolates from Turkey and found that they are closely related to strains from Denmark, Iran, and Spain, all belonging to genogroup V, serotype A2 (Sp strain). Low genetic diversity was observed among the Turkish IPNV isolates, and certain amino acid residues may be associated with virulence.
JOURNAL OF FISH DISEASES
(2022)
Review
Fisheries
Irtifa Fayaz, Raja Aadil Hussain Bhat, Ritesh Shantilal Tandel, Pragyan Dash, Suresh Chandra, Maneesh Kumar Dubey, Parvaiz Ahmad Ganie
Summary: IPNV is a prevalent virus in salmonid fish, particularly rainbow trout, and its ability to survive in aquatic environments for extended periods poses a challenge for infection prevention and control. This review provides an in-depth analysis of IPNV, including its genome organization, virulence factors, diagnostic tools, and classification methods. It also discusses significant developments in antiviral treatments and the role of bioinformatics in mining knowledge about IPNV. Molecular docking experiments revealed that quercetin and EICAR show strong binding to the VP2 protein of IPNV and have better potential for preventing IPNV compared to other known anti-IPN drugs.
Review
Gastroenterology & Hepatology
Alain P. Gobert, Keith T. Wilson
Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Afreen Shadan, Avik Pathak, Ying Ma, Ranjana Pathania, Rajnish Prakash Singh
Summary: This article reviews the mechanisms, virulence factors, and other factors associated with the pathogenesis of A. baumannii infection. Additionally, it discusses the role of innate and adaptive immune response, as well as the current progress in developing innovative strategies to combat this multidrug-resistant pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
David Tapia, Juan Kuznar, Rodolfo Farlora, Jose M. Yanez
Summary: The study found that rainbow trout exhibited a differential transcriptomic response to infection with two genetically distinct IPNV isolates from Chile, with RTTX infection eliciting a greater modulation of trout transcriptome. Functions related to immune and inflammatory responses were modulated in infected fish, with different regulation patterns depending on the isolate used.
Article
Microbiology
Castrejon-Jimenez Nayeli Shantal, Castillo-Cruz Juan, Baltierra-Uribe Shantal Lizbeth, Hernandez-Gonzalez Juan Carlos, Garcia-Perez Blanca Estela
Summary: This review discusses the virulence factors, immune response evasion strategies, and intracellular behavior of Candida glabrata. By comparing it with Mycobacterium tuberculosis, the review highlights the successful pathogenicity of C. glabrata in manipulating the immune response.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Fisheries
Xing Lv, Qiang Luo, Shiying Xin, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In recent years, there has been an increasing focus on the study of circular RNAs (circRNAs) in noncoding RNAs. While circRNAs are abundant in mammalian studies, research in lower vertebrates has been lacking. In this study, a circRNA called circPlce1 was found to be related to the innate immune response in Miichthys miiuy (miiuy croaker). Experimental results showed that circPlce1 could promote the production of antiviral genes and inflammatory response. It was also observed that circPlce1 can promote cell proliferation and improve cell viability. The study provides a foundation for understanding the biological function of circRNAs in the innate immune response in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Josef Vaclavik, Pavla Sehonova, Jana Blahova, Denisa Medkova, Eva Postulkova, Ondrej Maly, Michaela Charvatova, Kamil Stastny, Jiri Lenz, Jan Mares, Ales Franc, Zdenka Svobodova
Summary: The aim of this study was to investigate the effects of foodborne fluoxetine on juvenile rainbow trout. The results showed significant changes in hematological profile, liver and kidney detoxifying enzyme activity, and damage to the proximal tubules of the caudal kidney, confirming the importance of its impact on immune response.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Immunology
Carlos Munoz, Josue Gonzalez-Lorca, Mick Parra, Sarita Soto, Natalia Valdes, Ana Maria Sandino, Rodrigo Vargas, Alex Gonzalez, Mario Tello
Summary: The study explored the use of Lactococcus lactis as a type I interferon expression system in Atlantic salmon to stimulate the antiviral immune response, showing that oral administration of L. lactis producing interferon I induces systemic effects, reduces IPNV viral load, and increases Mx and PKR expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Susan M. Brewer, Christian Twittenhoff, Jens Kortmann, Sky W. Brubaker, Jared Honeycutt, Liliana Moura Massis, Trung H. M. Pham, Franz Narberhaus, Denise M. Monack
Summary: Bacterial pathogens adjust their virulence factor expression in response to temperature changes through an RNA thermosensor, impacting their survival and infection capability. Specific pathogens like Salmonella enterica serovar Typhi (S. Typhi) regulate gene expression to successfully infect hosts and evade immune responses.
Article
Multidisciplinary Sciences
Xukang Shen, Siliang Song, Chuan Li, Jianzhi Zhang
Summary: Synonymous mutations in protein-coding genes are not neutral and often result in reduced fitness and disturbed mRNA expression levels. Non-synonymous mutations have greater fitness variations across environments, which may explain the lower substitution rates compared to synonymous mutations.
Article
Environmental Sciences
Maya E. Natnan, Chen-Fei Low, Chou-Min Chong, Hamidun Bunawan, Syarul N. Baharum
Summary: The increasing demand for fish protein has led to a rise in fish production through aquaculture and wild capture. Pathogen infections in hatcheries and grow-out ponds have resulted in reduced productivity and economic losses for farmers. Utilizing omics datasets and systems biology approaches can help scientists understand complex host-pathogen interactions and identify new targets for combating diseases in aquaculture. Various omics approaches such as genomics, transcriptomics, proteomics, and metabolomics are valuable tools in developing treatment and prevention strategies to address aquaculture diseases caused by microbial infections.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tobias Sahr, Pedro Escoll, Christophe Rusniok, Sheryl Bui, Gerard Pehau-Arnaudet, Gregory Lavieu, Carmen Buchrieser
Summary: This study reveals that Legionella pneumophila mimics eukaryotic microRNA to modulate the host response to infection. This miRNA-like regulation is a feature of host-pathogen communication and may represent a general mechanism used by bacteria that interact with eukaryotic hosts.
NATURE COMMUNICATIONS
(2022)
Article
Fisheries
Lill-Heidi Johansen, Hanna L. Thim, Sven Martin Jorgensen, Sergey Afanasyev, Guro Strandskog, Torunn Taksdal, Kjersti Fremmerlid, Marion McLoughlin, Jorunn B. Jorgensen, Aleksei Krasnov
FISH & SHELLFISH IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Dimitar Iliev, Guro Strandskog, Arpita Nepal, Augusta Aspar, Randi Olsen, Jorunn Jorgensen, Deanna Wolfson, Balpreet Singh Ahluwalia, Jordan Handzhiyski, Roumyana Mironova
Article
Multidisciplinary Sciences
Shiferaw Jenberie, Hanna L. Thim, J. Oriol Sunyer, Karsten Skjodt, Ingvill Jensen, Jorunn B. Jorgensen
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Dimitar B. Iliev, Ingrid Skjaeveland, Jorunn B. Jorgensen
Article
Fisheries
Astrid Skjesol, Theresa Liebe, Dimitar B. Iliev, Ernst I. S. Thomassen, Linn Greiner Tollersrud, Mehrdad Sobhkhez, Lisbeth Lindenskov Joensen, Christopher J. Secombes, Jorunn B. Jorgensen
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2014)
Article
Fisheries
Soren Grove, Lars Austbo, Kjartan Hodneland, Petter Frost, Marie Lovoll, Marian McLoughlin, Hanna L. Thim, Stine Braaen, Melanie Konig, Mohasina Syed, Jorunn B. Jorgensen, Espen Rimstad
FISH & SHELLFISH IMMUNOLOGY
(2013)
Article
Fisheries
Dimitar B. Iliev, Tom Hansen, Sven Martin Jorgensen, Aleksei Krasnov, Jorunn B. Jorgensen
FISH & SHELLFISH IMMUNOLOGY
(2013)
Article
Fisheries
K. Julin, L-H Johansen, A-I Sommer, J. B. Jorgensen
JOURNAL OF FISH DISEASES
(2015)
Article
Biochemistry & Molecular Biology
Mehrdad Sobhkhez, Astrid Skjesol, Ernst Thomassen, Linn Greiner Tollersrud, Dimitar B. Iliev, Baojian Sun, Borre Robertsen, Jorunn B. Jorgensen
Article
Fisheries
Maria K. Dahle, Jorunn B. Jorgensen
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Immunology
Muhammad Salman Malik, Lena H. Teige, Stine Braaen, Anne Berit Olsen, Monica Nordberg, Marit M. Amundsen, Kannimuthu Dhamotharan, Steingrim Svenning, Eva Stina Edholm, Tomokazu Takano, Jorunn B. Jorgensen, Oystein Wessel, Espen Rimstad, Maria K. Dahle
Summary: This study suggests that infection with non-pathogenic, replicating PRV may be a future strategy to protect farmed salmon from HSMI.
Article
Fisheries
Yorick A. van der Wal, Shiferaw Jenberie, Henriette Nordli, Linn Greiner-Tollersrud, Jaap Kool, Ingvill Jensen, Jorunn B. Jorgensen
Summary: The study showed that the intraperitoneal route is suitable for administering vaccines in Atlantic salmon, but the immune responses in the peritoneal cavity are not fully understood. Following Piscirickettsia salmonis challenge, B cell responses were found to increase significantly in the PerC, spleen, and head kidney. The serum antibody response included specific antibodies for P. salmonis, as well as non-specific antibodies for other pathogens. Additionally, adipose tissue may play a role in the PerC immune response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Dimitar B. Iliev, Leidy Lagos, Hanna L. Thim, Sven M. Jorgensen, Aleksei Krasnov, Jorunn B. Jorgensen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Fisheries
Mehrdad Sobhkhez, Lisbeth L. Joensen, Linn Greiner Tollersrud, Guro Strandskog, Hanna L. Thim, Jorunn B. Jorgensen
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Immunology
Hanna L. Thim, Stephane Villoing, Marian McLoughlin, Karen Elina Christie, Soren Grove, Petter Frost, Jorunn B. Jorgensen