Article
Veterinary Sciences
Michael J. Clayton, E. Jane Kelly, Marta Mainenti, Amanda Wilhelm, Mia Kim Torchetti, Mary Lea Killian, Arnaud J. Van Wettere
Summary: An outbreak of respiratory disease caused by influenza A(H1N1)2009 virus affected kits and adult mink on a farm in Utah, resulting in deaths in kits. The source of the virus was suspected to be reverse zoonosis. This case highlights the importance of monitoring interspecies transmission of influenza on mink farms and practicing safe work practices.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2022)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Moegi Kuroda, Tatsufumi Usui, Chiharu Shibata, Haruka Nishigaki, Tsuyoshi Yamaguchi
Summary: In 2019, a case of bidirectional infection between humans and pigs occurred in a swine farm in Japan. An employee with influenza-like illness transmitted the infection to sows, which subsequently infected a veterinarian and her family. Whole-genome analysis confirmed that the viruses isolated from all individuals belonged to the same lineage. Unique mutations in the influenza A virus genomes corresponding to the host species were also identified.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
V. S. Vakin, I. Amosova, E. M. Vojcekhovskaya, T. A. Timoshicheva, A. A. Vasileva, M. G. Pozdnyakova, L. Lyalina, V. A. Marchenko, I. Yu Nikonorov, M. P. Grudinin
Summary: Currently, the immunogenic properties of influenza vaccines are primarily assessed through seroprotection, seroconversion, and post-vaccination antibody level increase rate. This study analyzed the immunogenicity of influenza vaccines used during the 2009-2010 pandemic and the post-pandemic period, and proposed a method for assessing immunogenicity. Results revealed differences in immune response to the A(H1N1)pdm09 vaccine among adults and children, possibly due to insufficient vaccine dose or immune suppression caused by the A(H1N1)pdm09 virus.
INFEKTSIYA I IMMUNITET
(2022)
Article
Immunology
Veronica A. Ferrando, Marcel E. Friedrich, Shrey Gandhi, Alexander Mellmann, Doerthe Masemann, Anmari Christersson, Darisuren Anhlan, Linda Brunotte, Monika Stoll, Timm Harder, Martin Beer, Yvonne Boergeling, Stephan Ludwig
Summary: Influenza A viruses, including the H1N1pdm09 virus, cause recurrent epidemics and occasional pandemics in humans. The reassortment of these viruses in swine and their ability to replicate in human lung tissue suggest a possible zoonotic potential. Reassortment frequently occurs in the PB1, PA, and NA segments, resulting in the generation of reassortants that can reach high titers in swine lung cells.
EMERGING MICROBES & INFECTIONS
(2023)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Biotechnology & Applied Microbiology
Zhihong Qian, Dylan H. H. Morris, Annika Avery, Karen A. A. Kormuth, Valerie Le Sage, Michael M. M. Myerburg, James O. O. Lloyd-Smith, Linsey C. C. Marr, Seema S. S. Lakdawala
Summary: Respiratory viruses can be transmitted through contaminated surfaces, or fomites. This study examined the stability of the H1N1 virus on different surface materials at varying humidities. The results showed that the virus was rapidly inactivated on copper, but remained stable on plastics, steel, aluminum, and glass. The stability of the virus was more influenced by the respiratory secretion of the host than the surface material.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong
Summary: This study aimed to investigate the association between IFITM1 gene polymorphisms and susceptibility to pandemic influenza A 2009 H1N1 virus infection. Despite finding 3 novel SNPs, no significant association was observed between IFITM1 SNPs and susceptibility to H1N1 virus infection. Additionally, strong linkage disequilibrium was found between IFITM1 SNPs and IFITM3 SNPs.
MOLECULAR & CELLULAR TOXICOLOGY
(2021)
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Seungwon Kim, Margaret Carrel, Andrew Kitchen
Summary: Identifying the spatial patterns of genetic structure of influenza A viruses is important for understanding their spread. This study analyzed the genetic sequences of the A/H1N1pdm09 virus in mainland China and found that there is high genetic similarity among viruses within small geographic regions, but broad-scale genetic differentiation. Local viral circulation has a greater impact on the spatial genetic structure of the virus than countrywide viral mixing and gene flow.
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Xiao-Yan Liu, Gui-Yun Cao, Yi Luo, Zhao-Qing Meng, You-Bo Zhang
Summary: This study investigates the effect of Xilingjiedu capsule on influenza A (H1N1) virus and its mechanism. The results show that Xilingjiedu capsule has anti-H1N1 activity and its mechanism is related to the Toll-like signaling pathway. This research provides important references for the application of Xilingjiedu capsule in antiviral treatment.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Virology
Yan-Na Xiao, Fei-Yuan Yu, Qian Xu, Jiang Gu
Summary: This study investigated the expression of influenza virus receptors in the human placenta and found that it is susceptible to 2009 influenza A virus (H1N1/09) infection. The study highlights the importance of protecting pregnant women from infection during influenza season.
Article
Virology
Cihan Papan, Alberto Argentiero, Ortwin Adams, Marian Porwoll, Ummaya Hakim, Edoardo Farinelli, Ilaria Testa, Maria B. Pasticci, Daniele Mezzetti, Katia Perruccio, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Ellen Bamberger, Sven Schneider, Susanna Esposito, Tobias Tenenbaum
Summary: This study found that viral load is associated with biomarkers and may serve as a complementary tool for assessing disease severity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Serafina Perrone, Sara Manti, Luca Buttarelli, Chiara Petrolini, Giovanni Boscarino, Laura Filonzi, Eloisa Gitto, Susanna Maria Roberta Esposito, Francesco Nonnis Marzano
Summary: Bronchopulmonary dysplasia (BPD) is still a significant burden in neonatal care, and its definition is currently based on treatment rather than diagnostic criteria. BPD is associated with various prenatal and postnatal risk factors, causing distorted lung development and function. Inflammation and oxidative stress play key roles in BPD development, with vascular endothelial growth factor-A (VEGFA) being an important candidate. This educational review discusses the inflammatory pathways in BPD and highlights the role of VEGFA, providing an overview of current evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Javier Diez-Domingo, Xavier Saez-Llorens, Miguel A. Rodriguez-Weber, Cristina Epalza, Archana Chatterjee, Cheng-Hsun Chiu, Chien-Yu Lin, Andrea A. Berry, Federico Martinon-Torres, Fernando Baquero-Artigao, Joanne M. Langley, Jose T. Ramos Amador, Joseph B. Domachowske, Li-Min Huang, Nan-Chang Chiu, Susanna Esposito, Philippe Moris, Thi Lien-Anh Nguyen, Vanja Nikic, Wayne Woo, Yingjun Zhou, Ilse Dieussaert, Amanda Leach, Antonio Gonzalez Lopez, Nicolas Vanhoutte
Summary: This study tested a new candidate RSV vaccine in toddlers who had a previous RSV infection. The vaccine was effective in preventing RSV-related illnesses and triggered an antibody response that could neutralize the virus. No vaccine-related serious adverse events or RSV-related hospitalizations were reported during the study.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Letter
Dermatology
Paola Zelini, Eugenio Isoletta, Martina Volonte, Daniele Lilleri, Irene Cassaniti, Valeria Musella, Catherine Klersy, Fausto Baldanti, Valeria Brazzelli
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Nutrition & Dietetics
Maria Elena Capra, Brigida Stanyevic, Antonella Giudice, Delia Monopoli, Nicola Mattia Decarolis, Susanna Esposito, Giacomo Biasucci
Summary: The COVID-19 pandemic has had a significant impact on the nutrition and metabolic diseases in children and adolescents, leading to an increase in overweight, obesity, and type 2 diabetes. The accessibility to healthcare services has been limited, resulting in delayed diagnosis and more severe presentation of type 1 diabetes. Further studies are required to investigate these relationships and develop strategies to mitigate the nutritional and metabolic impact in the developmental ages.
Review
Pharmacology & Pharmacy
Nicola Principi, Giovanni Autore, Serafina Perrone, Susanna Esposito
Summary: RSV is a common respiratory virus that has a significant impact on patients, healthcare systems, and society worldwide. This paper discusses the characteristics of RSV and the current development of new pharmacological measures against this virus.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Infectious Diseases
Danilo Buonsenso, Giovanni Autore, Francesca Cusenza, Lucrezia Passadore, Francesca Bonanno, Susanna Esposito
Summary: The spread of drug-resistant tuberculosis (TB) has led to the development of new drugs and the reappraisal of old drugs. Ensuring access to child-friendly medicines for drug-resistant TB is crucial for reducing the global burden of TB. This perspective highlights the need for child-friendly formulations of second-line drugs to improve adherence to treatment regimens and prevent the development of additional drug resistance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Jose Camilla Sammartino, Marta Colaneri, Cecilia Bassoli, Mariaelena Ceresini, Antonio Piralla, Alessandro Ferrari, Elena Percivalle, Fausto Baldanti, Raffaele Bruno, Mario U. Mondelli
Summary: This study aimed to verify the presence of viable virus on different surfaces exposed to droplets released by coughing in SARS-CoV-2 RNA positive patients. The results showed that droplets on common inanimate surfaces did not contain viable virus, while laboratory-propagated viruses could survive and grow on the same surfaces.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Immunology
Marta Colaneri, Raffaella Lissandrin, Matteo Calia, Cecilia Bassoli, Elena Seminari, Alessandro Pavesi, Francesca Rovida, Fausto Baldanti, Alba Muzzi, Guido Chichino, Angelo Regazzetti, Cecilia Grecchi, Angelo Pan, Matteo Lupi, Erica Franceschini, Cristina Mussini, Raffaele Bruno
Summary: This study aimed to assess the efficacy of steroid therapy in reducing intrahospital mortality, length of stay, and neurological sequelae in WNND patients. The results showed that steroid therapy did not significantly reduce intrahospital mortality or neurological sequelae. More prospective data are needed to demonstrate the protective effect of steroid treatment.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Eun Kim, Muhammad S. Khan, Alessandro Ferrari, Shaohua Huang, Jose C. Sammartino, Elena Percivalle, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Andrea Gambotto
Summary: The study evaluates the booster effect of an S1 subunit vaccine in aged mice previously primed with adenoviral vaccines. It demonstrates that a booster dose of the rS1Beta subunit vaccine, given to mice, induces strong and long-lived S1-specific immune responses and significantly increases neutralizing antibodies against Wuhan, Beta, and Delta strains, including cross-reactive antibodies against Omicron variants. The findings suggest that the rS1Beta subunit vaccine can offer cross-neutralization against broad variants, providing important implications for controlling breakthrough SARS-CoV-2 variants in elderly individuals primed with adenovirus-based vaccines.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Valentina Zuccaro, Greta Petazzoni, Irene Mileto, Marta Corbella, Erika Asperges, Paolo Sacchi, Sara Rattotti, Marzia Varettoni, Irene Defrancesco, Patrizia Cambieri, Fausto Baldanti, Luca Arcaini, Raffaele Bruno
Summary: Several studies have shown a strong connection between gut microbiota and the response to immunotherapy in tumor patients, suggesting that gut microbiota can serve as a biomarker for response. This study aimed to compare the gut microbiota diversity in chronic lymphocytic leukemia patients treated with B-cell receptor inhibitors for at least 12 months. The findings revealed differences in bacterial distribution between different response groups.
Article
Microbiology
Paola Zelini, Piera d'Angelo, Federica Zavaglio, Ehsan Soleymaninejadian, Liliana Mariani, Francesca Perotti, Mattia Dominoni, Stelvio Tonello, Pierpaolo Sainaghi, Rosalba Minisini, Daria Apostolo, Daniele Lilleri, Arsenio Spinillo, Fausto Baldanti
Summary: In this prospective study, it was found that vaccinated pregnant women and their newborns had higher levels of cytokines and immune responses after SARS-CoV-2 infection. Additionally, the newborns of vaccinated mothers had higher levels of specific antibodies. Vaccination can enhance the immune profile of pregnant women and provide immune protection to newborns.
Article
Immunology
Simona Secondino, Paolo Pedrazzoli, Sabrina Basso, Paolo Bossi, Alba Bianco, Ilaria Imarisio, Anna Pagani, Marica De Cicco, Stella Muscianisi, Michela Casanova, Carlo Morosi, Cristiana Bergamini, Marco Benazzo, Maria Cossu Rocca, Cesare Perotti, Fausto Baldanti, Marco Zecca, Lisa F. Licitra, Patrizia Comoli
Summary: This study aimed to explore the efficacy of autologous EBV-specific CTL transplantation in the treatment of recurrent/metastatic EBV-NPC patients after chemotherapy. The results showed that patients who received CTL transplantation had a 5-year overall survival rate of 44% and a median overall survival of 60 months. This indicates that autologous CTL transplantation can effectively control the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Letizia Paglialonga, Camilla Aurelio, Nicola Principi, Susanna Esposito
Summary: This article summarizes the available evidence on the return to play in children after SARS-CoV-2 infection, suggesting a clinical practice algorithm and highlighting priorities for future studies. The severity of COVID-19 and the presence of underlying diseases are criteria for identifying subjects requiring laboratory and radiological tests before returning to physical activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Angioletta Lasagna, Irene Cassaniti, Francesca Arena, Federica Bergami, Elena Percivalle, Giuditta Comolli, Antonella Sarasini, Alessandro Ferrari, Daniela Cicognini, Roberta Schiavo, Giuliana Lo Cascio, Paolo Pedrazzoli, Fausto Baldanti
Summary: We prospectively evaluated the long-term immunogenicity of the third dose of the SARS-CoV-2 BNT162b2 mRNA vaccine in 55 patients undergoing cancer treatment. Our findings indicate that one year after receiving the third dose, more than 67% of patients showed an immune response against the virus, with less than 20% of patients showing no response to certain variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)