Article
Immunology
Xiang Nie, Huihui Li, Jin Wang, Yuanyuan Cai, Jiahui Fan, Beibei Dai, Chen Chen, Dao Wen Wang
Summary: The study revealed that the expression of lncRNAs is significantly dysregulated in acute myocarditis, potentially playing different roles in the progression of AM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Yimin Xue, Jun Ke, Xiaofen Zhou, Qian Chen, Mingguang Chen, Tingfeng Huang, Fenghui Lin, Feng Chen
Summary: This study demonstrated that MALAT1 knockdown can alleviate the severity of coxsackievirus B3-induced AVMC in mice by inhibiting Th17 cells differentiation. MALAT1 may serve as a novel therapeutic option for AVMC.
Article
Virology
Chengrui Niu, Wei Xu, Sidong Xiong
Summary: The appendix plays a role in regulating the composition of the intestinal microbiota and has an impact on cardiac infection and inflammation.
Article
Immunology
Mahadappa Priyanka, H. B. Ranjitha, M. Karikalan, S. Chandramohan, Subhasmitha Behera, V. Gnanavel, Tamil Selvan Ramasamy Periyasamy, V. Umapathi, H. J. Dechamma, Narayanan Krishnaswamy
Summary: It was found that FMDV infection leads to overexpression of CAR in the myocardium of suckling mice, which may be the reason for their susceptibility to viral myocarditis.
MICROBIAL PATHOGENESIS
(2023)
Article
Chemistry, Applied
Li Qin, Hui Liu, Jinghua Wang, Wei Wang, Lei Zhang
Summary: The study demonstrated that crocetin has a cardio-protective effect in an experimental murine model of acute viral myocarditis, increasing survival rates, reducing myocardial necrotic lesions, and inhibiting viral replication and inflammatory response. These findings suggest that crocetin may be a potential therapeutic agent for patients with viral myocarditis.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Microbiology
Yuxuan Fu, Sidong Xiong
Summary: This study found that exosomes can serve as vehicles for CVB3 virus, delivering the virus into cells and infecting receptor-negative cells. Exosomes carrying CVB3 virus have higher infection efficiency compared to free virus, and can overcome restrictions to viral tropism by accessing different routes.
Article
Immunology
Liang Chen, Meng-ying Zhu, Gao-xiang Wang, Li-Li Lu, Li Lin, Lei Lei, Ting Wu
Summary: This study found that ruxolitinib can improve acute viral myocarditis caused by Coxsackievirus B3 by inhibiting the activation of the JAK-STAT pathway, reducing inflammatory cell infiltration and necroptosis of the myocardium. This finding provides a new strategy for the treatment of viral myocarditis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vipul Sharma, Lisa S. Goessling, Anoop K. Brar, Chetanchandra S. Joshi, Indira U. Mysorekar, Pirooz Eghtesady
Summary: Prenatal infection with CVB3 can induce congenital heart defects in fetuses, with a dose-response relationship observed between viral titers and defect severity. Following exposure to CVB3, a significant decrease in cardiomyocyte proliferation was identified as the main cause for alterations in cardiac architecture and trabeculation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Virology
Tingjun Liu, Jing Tong, Chen Shao, Junyan Qu, Hua Wang, Yi Shi, Yajing Lin, Yun Liu, Shihe Shao, Hongxing Shen
Summary: The study showed that miR-324-3p targets TRIM27 to inhibit CVB3 replication and reduce viral load, thereby alleviating cardiac injury associated with viral myocarditis.
Review
Immunology
Parisa Shiri Aghbash, Nima Hemmat, Javid Sadri Nahand, Ali Shamekh, Mohammad Yousef Memar, Abouzar Babaei, Hossein Bannazadeh Baghi
Summary: This review provides an overview of recent advances in understanding the function of Th17 cells and their produced cytokines in viral diseases. It emphasizes the role of these cells in immune responses, chronic inflammation, tumor growth, and progression of viral diseases. Further research is needed to fully comprehend the immune mechanisms of Th17 cells in various viral diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Xiang Nie, Jiahui Fan, Huihui Li, Jin Wang, Rong Xie, Chen Chen, Dao Wen Wang
Summary: This study suggests that dysregulation of cardiac circRNAs is an important characteristic of viral myocarditis, and is strongly correlated with immune response. The dysregulation of circRNAs in different mouse strains is associated with varying degrees of cardiac dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mingxin Zhu, Han Yang, Yang Lu, Hongmin Yang, Yaohan Tang, Lixia Li, Yaoxi Zhu, Jing Yuan
Summary: This study identified the formation of ELFs in myocardial tissues of VMC, with the number of ELFs correlating with the severity of VMC. Functional ELFs with GCs were found to facilitate the production of local AHA, potentially offering new opportunities for stratification and early identification of VMC patients.
Article
Cell Biology
Pengcheng Yan, Xiaoning Song, Joanne Tran, Runfa Zhou, Xinran Cao, Gang Zhao, Haitao Yuan
Summary: This study found that dapagliflozin has a protective effect on viral myocarditis by alleviating myocardial inflammation and improving cardiac function. It also activates the Stat3 signaling pathway to promote anti-inflammatory macrophage polarization and reduce cardiac injury.
Article
Cell Biology
Pengcheng Yan, Xiaoning Song, Joanne Tran, Runfa Zhou, Xinran Cao, Gang Zhao, Haitao Yuan
Summary: Dapagliflozin has a protective effect on viral myocarditis, reducing its severity, improving survival rate, and ameliorating cardiac function. It decreases pro-inflammatory cytokines levels, inhibits macrophage differentiation to M1 phenotype, and activates the polarization of M2 phenotype through the Stat3 signal pathway.
Article
Cardiac & Cardiovascular Systems
Haiyan Lei, Dandan Wang, Haiyong Wang, Yuansheng Xu
Summary: This article reports a case of coxsackie virus induced myocarditis in children, resulting in constrictive pericarditis.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)