Article
Biochemistry & Molecular Biology
Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu-ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin-ichiro Honda
Summary: In this study, researchers found that SRT1720 can induce cell death in adult T-cell leukemia/lymphoma (ATL) cells through apoptosis and autophagy, and it exhibits anti-tumor activity.
Article
Food Science & Technology
Simin Chen, Claudia Figueiredo Lossio, Isabel Verbeke, Joost Verduijn, Bogdan Parakhonskiy, Louis Van der Meeren, Pengyu Chen, Jeroen De Zaeytijd, Andre G. Skirtach, Els J. M. Van Damme
Summary: The study found that OsRIP1 can inhibit protein synthesis in a sustained manner, leading to reduced proliferation of HeLa cells with apoptotic-like changes in the cell membrane, but without causing DNA fragmentation. OsRIP1 also interacts with ASPP1 and IFITM3, causing changes in the transcription levels of important genes in the cells, inducing a caspase-independent cell death process in HeLa cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Article
Immunology
Hannah L. Wallace, Lingyan Wang, Cassandra L. Gardner, Christopher P. Corkum, Michael D. Grant, Kensuke Hirasawa, Rodney S. Russell
Summary: This study investigated the mechanism of HCV-induced cell death, revealing that pyroptosis occurs earlier than apoptosis during infection. Knockout of NLRP3 and gasdermin-D affected HCV-induced pyroptosis, and there may be crosstalk between caspase-3 and pyroptosis initiation in the context of HCV infection. Lower viral titres and increased intracellular virus levels were observed in knockout Huh-7.5 cells, suggesting HCV may induce programmed cell death to enhance virus release. These results contribute to understanding HCV pathogenesis and suggest various programmed cell death pathways are not mutually exclusive.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Polymer Science
Balint Viktor Lovasz, Gergely Berta, Edina Lempel, Gyorgy Setalo, Monika Vecsernyes, Jozsef Szalma
Summary: The study suggests that relevant concentrations of TEGDMA monomers leached from resin-based composite materials (RBCs) induce apoptosis in pulp cells through both caspase-dependent and caspase-independent mechanisms, possibly involving endoplasmic reticulum stress and the activation of caspase-independent apoptotic pathways.
Article
Biochemistry & Molecular Biology
Leo Razakamanantsoa, Neeraj R. Rajagopalan, Yasushi Kimura, Michele Sabbah, Isabelle Thomassin-Naggara, Francois H. Cornelis, Govindarajan Srimathveeravalli
Summary: Irreversible electroporation (IRE) can cause apoptosis, necrosis, oncosis, or pyroptosis. The mode of cell death following IRE is determined by intracellular ATP levels. Cell death after IRE is insensitive to caspase inhibition and is correlated with ATP loss, which cannot be rescued by ATP supplementation.
BIOELECTROCHEMISTRY
(2023)
Article
Virology
Joey McGregor, Joshua M. Hardy, Chan-Sien Lay, Irene Boo, Michael Piontek, Manfred Suckow, Fasseli Coulibaly, Pantelis Poumbourios, Rob J. Center, Heidi E. Drummer
Summary: There is currently no vaccine for hepatitis C virus, but researchers have developed a virus-like particle vaccine that can induce the production of neutralizing antibodies and has shown immunogenicity in guinea pigs. This vaccine platform holds promise as a low-cost candidate for large-scale production of an HCV vaccine.
JOURNAL OF VIROLOGY
(2022)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Virology
Savvina Moustafa, Katerina Kassela, Maria Bampali, Nikolas Dovrolis, Athanassios Kakkanas, Apostolos Beloukas, Penelope Mavromara, Ioannis Karakasiliotis
Summary: This study analyzed the role of HCV core protein in TNF alpha-induced death, considering the genetic variability of HCV. The results showed that only HCV 4a core protein increased sensitivity to TNF alpha-induced death. Transgenic mice expressing HCV 4a core protein were more susceptible to the LPS/Dgal model, while mice expressing HCV 4f core protein had the same susceptibility as controls.
Article
Parasitology
Zi-Chen Zhao, Man-Yi Jiang, Ji-Hui Huang, Chuan Lin, Wei-Liang Guo, Zhi-Hong Zhong, Qing-Qin Huang, Shao-Long Liu, Heng-Wei Deng, Yong-Can Zhou
Summary: This study found that honokiol can induce apoptosis-like death in Cryptocaryon irritans tomonts. The results suggest that honokiol may induce tomont apoptosis-like death by disrupting calcium ion homeostasis, activating reactive oxygen species, and modulating apoptosis-related pathways.
PARASITES & VECTORS
(2023)
Article
Biophysics
Suchanat Boonkaew, Abdulhadee Yakoh, Nattaya Chuaypen, Pisit Tangkijvanich, Sirirat Rengpipat, Weena Siangproh, Orawon Chailapakul
Summary: Electrochemical paper-based analytical devices (ePADs) are simple, portable, and low-cost analytical devices for point-of-care testing of clinical biomarkers. A sequential ePAD has been developed for simultaneous detection of hepatitis B surface antigen and hepatitis C core antigen by integrating dual flow behaviors, avoiding the need for complex multi-step reagent manipulation by the user. The proposed ePAD shows high promise as an easy-to-use, portable, and extendable sensor for other multiplex biological assays.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Environmental Sciences
Zhuanxu Ouyang, Bijing Yang, Jiangnan Yi, Shanshan Zhu, Suge Lu, Yingwei Liu, Yangwei Li, Yuanliang Li, Khalid Mehmood, Riaz Hussain, Muhammad Ijaz, Jianying Guo, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: This study revealed the harmful effects of sodium fluoride on liver tissues of ducks, including promoting apoptosis and altering the expression levels of key genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Sungkyung Cha, Inbeom Park, Kyung Lib Jang
Summary: PA28 gamma activated by HCV core protein degrades p16 levels, leading to increased cell proliferation in hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Johnathan D. Guest, Ruixue Wang, Khadija H. Elkholy, Andrezza Chagas, Kinlin L. Chao, Thomas E. Cleveland, Young Chang Kim, Zhen-Yong Keck, Alexander Marin, Abdul S. Yunus, Roy A. Mariuzza, Alexander K. Andrianov, Eric A. Toth, Steven K. H. Foung, Brian G. Pierce, Thomas R. Fuerst
Summary: The variability of HCV poses a challenge for vaccine development, but a soluble form of E1E2 has been designed to elicit neutralizing antibodies in vivo and potentially optimize E1E2-based antigen production for future studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Zirui Liu, Yiquan Li, Yilong Zhu, Nan Li, Wenjie Li, Chao Shang, Gaojie Song, Shanzhi Li, Jianan Cong, Tingyu Li, Zhiru Xiu, Jing Lu, Chenchen Ge, Xia Yang, Yaru Li, Lili Sun, Xiao Li, Ningyi Jin
Summary: Apoptin inhibits the viability of HCT116 cells through inducing pyroptosis mediated by GSDME, as well as enhancing intracellular ROS production. The findings in nude mice xenografted with HCT116 cells demonstrate that Apoptin induces pyroptosis and significantly inhibits tumor growth. These discoveries provide a new strategy for colorectal cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Stefan Driessen, Niklas Berleth, Olena Friesen, Antje S. Loeffler, Philip Boehler, Nora Hieke, Fabian Stuhldreier, Christoph Peter, Kay O. Schink, Sebastian W. Schultz, Harald Stenmark, Petter Holland, Anne Simonsen, Sebastian Wesselborg, Bjoern Stork
Article
Cell Biology
Nora Hieke, Antje S. Loeffler, Takeshi Kaizuka, Niklas Berleth, Philip Boehler, Stefan Driessen, Fabian Stuhldreier, Olena Friesen, Kaivon Assani, Katharina Schmitz, Christoph Peter, Britta Diedrich, Joern Dengjel, Petter Holland, Anne Simonsen, Sebastian Wesselborg, Noboru Mizushima, Bjoern Stork
Article
Hematology
Rebecca I. Schleicher, Frank Reichenbach, Peter Kraft, Anil Kumar, Mario Lescan, Franziska Todt, Kerstin Goebel, Ingo Hilgendorf, Tobias Geisler, Axel Bauer, Marcus Olbrich, Martin Schaller, Sebastian Wesselborg, Lorraine O'Reilly, Sven G. Meuth, Klaus Schulze-Osthoff, Meinrad Gawaz, Xuri Li, Christoph Kleinschnitz, Frank Edlich, Harald F. Langer
Article
Oncology
Fabian Stuhldreier, Stefanie Kassel, Lena Schumacher, Sebastian Wesselborg, Peter Proksch, Gerhard Fritz
Review
Biochemistry & Molecular Biology
Sebastian Wesselborg, Bjoern Stork
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Marian Frank, Hendrik Niemann, Philip Boehler, Bjoern Stork, Sebastian Wesselborg, Wenhan Lin, Peter Proksch
CURRENT MEDICINAL CHEMISTRY
(2015)
Article
Cell Biology
Tamara Hornstein, Sarah Lehmann, Denise Philipp, Susanne Detmer, Michele Hoffmann, Christoph Peter, Sebastian Wesselborg, Klaus Unfried, Joachim Windolf, Sascha Flohe, Adnana Paunel-Goerguelue
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Marta Czugala, Olga Mykhaylyk, Philip Boehler, Jasmine Onderka, Boejrn Stork, Sebastian Wesselborg, Friedrich E. Kruse, Christian Plank, Bernhard B. Singer, Thomas A. Fuchsluger
Article
Plant Sciences
Amin Mokhlesi, Fabian Stuhldreier, Katharina W. Wex, Anne Berscheid, Rudolf Hartmann, Nidja Rehberg, Parichat Sureechatchaiyan, Chaidir Chaidir, Matthias U. Kassack, Rainer Kalscheuer, Heike Broetz-Oesterhelt, Sebastian Wesselborg, Bjoern Stork, Georgios Daletos, Peter Proksch
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Multidisciplinary Sciences
Theresia Sarabhai, Christoph Peter, Anne-Kathrin Baer, Joachim Windolf, Borna Relja, Sebastian Wesselborg, Thorsten Wahlers, Adnana Paunel-Goerguelue
Article
Oncology
Katharina Krueger, Katharina Geist, Fabian Stuhldreier, Lena Schumacher, Lena Bluemel, Marc Remke, Sebastian Wesselborg, Bjoern Stork, Nicolaj Kloecker, Stefanie Bormann, Wynand P. Roos, Sebastian Honnen, Gerhard Fritz
Article
Cell Biology
Philip Boehler, Fabian Stuhldreier, Ruchika Anand, Arun Kumar Kondadi, David Schluetermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Wenxian Wu, Marian Frank, Hendrik Niemann, Elisabeth Wesbuer, Andreas Barbian, Tomas Luyten, Jan B. Parys, Stefanie Weidtkamp-Peters, Andrea Borchardt, Andreas S. Reichert, Aida Pena-Blanco, Ana J. Garcia-Saez, Samuel Itskanov, Alexander M. van der Bliek, Peter Proksch, Sebastian Wesselborg, Bjoern Stork
CELL DEATH & DISEASE
(2018)
Article
Biochemistry & Molecular Biology
A. M. Dieterle, P. Boehler, H. Keppeler, S. Alers, N. Berleth, S. Driessen, N. Hieke, S. Pietkiewicz, A. S. Loeffler, C. Peter, A. Gray, N. R. Leslie, H. Shinohara, T. Kurosaki, M. Engelke, J. Wienands, M. Bonin, S. Wesselborg, B. Stork
Article
Chemistry, Organic
Cong-Dat Pham, Rudolf Hartmann, Philip Boehler, Bjoern Stork, Sebastian Wesselborg, Wenhan Lin, Daowan Lai, Peter Proksch
Article
Biochemistry & Molecular Biology
Laura Schmitt, Ilka Hinxlage, Pablo A. Cea, Holger Gohlke, Sebastian Wesselborg
Summary: This article summarizes the research progress of polybrominated diphenyl ethers (PBDEs), including their sources, structure-activity relationships, environmental toxicology studies, and a promising anticancer therapeutic PBDE. The study found that P01F08 induces apoptosis through the intrinsic mitochondrial pathway, showing cytotoxicity and apoptosis induction capacity in Ramos and Jurkat lymphoma cells.