期刊
VIROLOGY
卷 454, 期 -, 页码 25-33出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.01.018
关键词
Picornavirus; Virus discovery; Emerging viruses; Developing country
类别
资金
- NIH grant [U54 AI057160]
- National Institutes of Health/National Center for Research Resources Washington University-ICTS [KL2 RR024994]
- Children's Discovery Institute [MD-FR-2013-292]
- Bill & Melinda Gates Foundation [OPP1016839]
- Burroughs Wellcome Fund
- Eli & Edythe Broad Fellow of the Life Sciences Research Foundation
- Bill and Melinda Gates Foundation [OPP1016839] Funding Source: Bill and Melinda Gates Foundation
We describe the identification of a novel picornavirus recovered from the fecal specimen of a Child in The Gambia, provisionally named rosavirus 2. Comparison of the rosavirus 2 complete genome demonstrated 71.9% nucleotide identity to its closest relative rosavirus M-7, an unclassified picornavirus identified from rodent fecal material. A unique RNA structure was predicted in the 3' UTR of rosavirus 2 that was conserved with rosavirus M-7 and cadiciviruses. We detected rosavirus 2 in four pediatric fecal specimens (0.55% prevalence) in a Gambian diarrheal case-control cohort, but we did not detect it in a panel of 634 pediatric diarrhea! stool specimens from the USA. There was no statistical evidence that rosavirus 2 was associated with diarrhea! cases. This study broadens our understanding of unknown viruses present in children in developing country settings. (c) 2014 Elsevier Inc. All rights reserved.
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