期刊
VIROLOGY
卷 466, 期 -, 页码 82-94出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.05.029
关键词
Cafeteria roenbergensis virus; CroV; NCLDV; Megavirales; Mimivirus; Giant virus; Virophage; Virion; Proteome; LC-MS/MS
类别
资金
- Natural Science and Engineering Research Council of Canada (NSERC) [311654-11, 109785]
- Tula Foundation through the Centre for Microbial Diversity and Evolution
- Gottlieb Daimler- and Karl Benz-Foundation, Germany
- University of British Columbia
- European Molecular Biology Organization (EMBO)
Cafeteria roenbergensis virus (CroV) is a giant virus of the Mimiviridae family that infects the marine phagotrophic flagellate C roenbergensis. CroV possesses a DNA genome of similar to 730 kilobase pairs that is predicted to encode 544 proteins. We analyzed the protein composition of purified CroV particles by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and identified 141 virion-associated CroV proteins and 60 host proteins. Data are available via ProteomeXchange with identifier PXD000993. Predicted functions could be assigned to 36% of the virion proteins, which include structural proteins as well as enzymes for transcription, DNA repair, redox reactions and protein modification. Homologs of 36 CroV virion proteins have previously been found in the virion of Acanthamoeba polyphaga mimivirus. The overlapping virion proteome of CroV and Mimivirus reveals a set of conserved virion protein functions that were presumably present in the last common ancestor of the Mimiviridae. (C) 2014 Elsevier Inc. All rights reserved.
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