期刊
VIROLOGY
卷 439, 期 2, 页码 152-162出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2013.02.015
关键词
Interferon; Interferon regulatory factor 7; Lymphocytic choriomeningitis virus; T cell
类别
资金
- National Health and Medical Research Council of Australia [512407]
- Deutsche Forschungsgemeinschaft [DFG HO3298/1-1]
- Australian Postgraduate Scholarship
The role of IRF7 in the host response to lymphocytic choriomeningitis virus (LCMV) Armstrong 53b infection of mice was investigated. Intracranial infection of IRF7 KO mice was associated with delayed onset of LCM, increased survival and significantly reduced expression of the Ifng gene in the brain but not in the periphery. IRF7 KO mice showed impaired control of LCMV replication and delayed clearance of LCMV. Similar numbers of activated anti-LCMV-GP(33-41) CD8+ T cells were present in the brain and spleens of infected WT and IRF7 KO mice. While plasma IFN-beta was increased to similar levels, IFN-alpha was markedly reduced in IRF7 KO compared with WT mice. Compared with IFN-beta, IFN-alpha was a less potent inhibitor of LCMV infection in vitro. In conclusion, IRF7 (1) is required for the early innate control of LCMV infection, likely through the regulation of the appropriate type I IFN response, and (2) is not required for the antiviral CD8+ T cell-dependent clearance of LCMV from infected tissues. (C) 2013 Elsevier Inc. All rights reserved.
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