期刊
VIROLOGY
卷 417, 期 1, 页码 113-125出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.05.007
关键词
Cap-independent translation; Long distance RNA:RNA interactions; Carmovirus; Kissing loop interactions; 3 ' Translational enhancers
类别
资金
- U.S. Public Health Service [GM 061515-05A2/G120CD]
- National Science Foundation [MCB-0615154]
- NIH [2T32AI051967-06A1]
Circularization of cellular mRNAs is a key event prior to translation initiation. We report that efficient translation of Saguaro cactus virus (SCV) requires a 3' translational enhancer (PTE) located partially in coding sequences. Unlike a similar PTE reported in the 3' UTR of Pea enation mosaic virus that does not engage in an RNA:RNA interaction (Wang Z. et al., J. Biol. Chem. 284, 14189-14202, 2009), the SCV PTE participates in long distance RNA:RNA interactions with hairpins located in the p26 ORF and in the 5' UTR of one subgenomic RNA. At least two additional RNA:RNA interactions are also present, one of which involves the p26 initiation codon. Similar PTE can be found in six additional carmoviruses that can putatively form long-distance interactions with 5' hairpins located in comparable positions. (C) 2011 Elsevier Inc. All rights reserved.
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