期刊
VIROLOGY
卷 411, 期 2, 页码 383-392出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.01.009
关键词
Baculovirus; Pathogenesis; Basal lamina; FGF
类别
资金
- National Institutes of Health [R21AI063089]
- United States Department of Agriculture [NRI 2001-35302-09983, NRI 2008-35302-18849]
The mechanisms used by baculoviruses to exit the midgut and cause systemic infection of their insect hosts have been debated for decades. After being ingested, baculoviruses reach the midgut, where several host barriers need to be overcome in order to establish successful infection. One of these barriers is the basal lamina, a presumably virus-impermeable extracellular layer secreted by the epithelial cells lining the midgut and trachea. This review discusses new evidence that demonstrates how these viruses breach the basal lamina and establish efficient systemic infections. The biochemical mechanisms involved in dismantling basal lamina during baculovirus infection may also provide new insights into the process of basal lamina remodeling in invertebrate and vertebrate animals. (C) 2011 Elsevier Inc. All rights reserved.
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