Review
Virology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Alfredo Briones-Herrera, Jose Pedraza-Chaverri
Summary: Research has shown that high-risk HPV infection is associated with the development of various cancers, while low-risk HPV infection mainly causes genital warts. High-risk HPV promotes tumor development by altering the expression of cellular proteins, while the oncogenic potential of low-risk HPV is relatively lower.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Cell Biology
Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yu-Lou Wu, Meng-Hsiu Wu, Liang-Tin Lin, Wen-Chien Huang, Jonathan D. Holz, Tzong-Jen Sheu, Jhih-Shian Lee, Richard N. Kitsis, Pei-Han Tai, Yi-Jang Lee
Summary: The study found that cofilin-1 plays a crucial role in cell senescence by affecting morphological changes and cell enlargement. It induces cell senescence through the regulation of p27(Kip1), independent of p53 and p16(INK4) expressions. Additionally, cofilin-1 upregulation can also induce the expression of p27(Kip1) by suppressing the TEAD1 transcription factor, which in turn leads to senescence-related phenotypes.
Review
Biochemistry & Molecular Biology
Ana Garcia-Osta, Jinya Dong, Maria Jesus Moreno-Aliaga, Maria Javier Ramirez
Summary: The cell cycle is regulated by factors such as p27(Kip1), which controls different functions in the nucleus and cytoplasm. In Alzheimer's disease, alterations to cell cycle events and increased neurogenesis have been observed, suggesting a role for p27(Kip1) in the disease process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Neha Jaiswal, Deeptashree Nandi, Pradeep Singh Cheema, Alo Nag
Summary: The study identifies Cdh1 as a novel interacting partner and degradation target of the HPV E7 oncoprotein, and demonstrates its importance in cervical carcinogenesis. The findings contribute to our understanding of E7-induced carcinogenesis and provide a potential therapeutic target for cervical carcinoma management.
Article
Cell Biology
Qun Xie, Ruirui Zhang, Dandan Liu, Jing Yang, Qiang Hu, Chao Shan, Xiaohan Li
Summary: This study investigated the effects of Apigenin and miR-512-3p in melanoma treatment. The results showed that Apigenin inhibited the expression of miR-512-3p and halted cell proliferation in melanoma cells. Furthermore, Apigenin treatment suppressed tumor growth in vivo by decreasing miR-512-3p levels and increasing p27 Kip1 protein levels.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Dhanraj Deshmukh, Jin Xu, Xi Yang, Hermela Shimelis, Shengyun Fang, Yun Qiu
Summary: The E3 ubiquitin ligase RNF6 promotes cell cycle progression by reducing p27 levels. RNF6 interacts with p27 independent of phosphorylation and enhances its ubiquitination and degradation. Knockdown of RNF6 expression inhibits CDK2/Cyclin E activity, resulting in decreased cell cycle progression and proliferation.
Article
Nutrition & Dietetics
Yunjeong Park, Sung Pil Choo, Gee Soo Jung, Sehee Kim, Min Jung Lee, Wooseok Im, Hyemin Park, Inha Lee, Jae Hoon Lee, Sihyun Cho, Young Sik Choi
Summary: This study evaluated the effects of formononetin on endometriosis progression and found that it inhibits the proliferation of endometria in patients with endometriosis through the regulation of p27, pSTAT3, and PR-B. Formononetin treatment also significantly reduced the number of endometriotic lesions in an endometriosis mouse model. It may be a potential non-hormonal treatment option for endometriosis.
Article
Multidisciplinary Sciences
Brian DeVeale, Leqian Liu, Ryan Boileau, Jennifer Swindlehurst-Chan, Bryan Marsh, Jacob W. Freimer, Adam Abate, Robert Blelloch
Summary: This study reveals the cell cycle structure of pluripotent embryonic stem cells and the relationship between G1/S restriction point, gene expression, and cellular differentiation. By genetically manipulating G1/S restriction point regulators miR-302 and P27, the researchers found that they can accelerate or delay the onset of phasic gene expression in mouse embryos. Additionally, loss of miR-302-mediated p21 or p27 suppression expedites embryonic stem cell differentiation, while a mutated Cyclin E blocks it. These findings provide new insights into our understanding of cellular differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Tianyang Liu, Lin Ma, Lianhao Song, Bingqing Yan, Siwei Zhang, Bozhi Wang, Nan Zuo, Xinlei Sun, Yongqiang Deng, Qiushi Ren, Yujun Li, Jingsong Zhou, Qi Liu, Lanlan Wei
Summary: This study investigates the impact of HPV on the key gene CENPM in HNSCC and its response to radiotherapy. The findings suggest that HPV enhances CENPM expression and makes HNSCC cells more sensitive to radiotherapy. This provides evidence for the potential clinical application of CENPM examination in difficult-to-treat HPV-negative cancers.
Review
Genetics & Heredity
Rosario Castro-Oropeza, Patricia Pina-Sanchez
Summary: Human Papillomavirus (HPV) is the most common oncogenic virus causing viral-associated cancers worldwide. Non-coding RNAs, including lncRNAs, miRNAs, and circRNAs, are dysregulated in HPV-related neoplasms and play a role in tumor progression and metastasis. Nuclear lncRNAs function as epigenetic regulators and control gene expression at the transcriptional level. Understanding the epigenetic alterations induced by HPV and the role of non-coding RNAs can provide insights into the development and treatment of HPV-associated cancers.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Ada Nowosad, Justine Creff, Pauline Jeannot, Raphael Culerrier, Patrice Codogno, Stephane Manenti, Laurent Nguyen, Arnaud Besson
Summary: In response to glucose starvation, p27 promotes autophagy by facilitating autophagosome trafficking along microtubule tracks via maintaining elevated microtubule acetylation through an ATAT1-dependent mechanism.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S. Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Katherine A. Donovan, Marta Palafox, Jorge S. Reis-Filho, Elisa de Stanchina, Eric S. Fischer, Neal Rosen, Violeta Serra, Andrew Koff, John D. Chodera, Nathanael S. Gray, Sarat Chandarlapaty
Summary: This study identifies CDK4/6 kinase activation as a common mechanism in oncogenic signaling-induced proliferation and develops a new strategy for inhibiting CDK4/6 kinases to overcome resistance.
Article
Oncology
Nima Hemmat, Mohammad Amin Doustvandi, Zahra Asadzadeh, Ahad Mokhtarzadeh, Behzad Baradaran, Hossein Bannazadeh Baghi
Summary: The study demonstrates that silencing the E5 protein in cervical cancer cells can slow down cell proliferation and increase apoptosis, which may help inhibit the progression of cervical cancer.
Article
Multidisciplinary Sciences
Anoop Kumar, Utkarsha Sahu, Pratima Kumari, Anshuman Dixit, Prashant Khare
Summary: This study presents the design of a multi-epitope chimeric vaccine against HPV infection for prophylactic and therapeutic purposes. Computational analysis and molecular dynamics simulation validate the stability and immunogenicity of the vaccine construct.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Mayu Narematsu, Yuji Nakajima
Summary: Research has shown that cryoinjury in chick embryonic hearts can be compensated for by residual myocytes, leading to restoration of transmural defects. The process involves changes and differences in the cell cycle; through experimental observation and analysis, the elongation and reversal of the cell cycle after cryoinjury in embryonic hearts have been revealed.
CELL AND TISSUE RESEARCH
(2021)
Correction
Infectious Diseases
Juan Carlos Catalan-Najera, Humberto Barrios-Camacho, Josefina Duran-Bedolla, Alan Sagal-Prado, Rigoberto Hernandez-Castro, Jorge Garcia-Mendez, Rayo Morfin-Oterod, Maria del Rosario Velazquez-Larios, Vianney Ortiz-Navarrete, Lourdes Gutierrez-Xicotencatl, Celia Alpuche-Aranda, Jesus Silva-Sanchez, Ulises Garza-Ramos
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Article
Oncology
Man-Hong Leung, Ho Tsoi, Chun Gong, Ellen P. S. Man, Stefania Zona, Shang Yao, Eric W. -F. Lam, Ui-Soon Khoo
Review
Oncology
Lourdes Gutierrez-Xicotencatl, Adolfo Pedroza-Saavedra, Lilia Chihu-Amparan, Azucena Salazar-Pina, Minerva Maldonado-Gama, Fernando Esquivel-Guadarrama
Summary: HPV is recognized as the main cause of cervical cancer, with low-risk and high-risk types. High-risk HPV types 16 and 18 are the most common worldwide. The oncogenic proteins E6 and E7 play a major role in cancer development, while E5 is involved in the early stages of transformation.
MOLECULAR CANCER RESEARCH
(2021)
Article
Cell Biology
Dachuan Shen, Lili Tian, Fangyu Yang, Jun Li, Xiaodong Li, Yiqun Yao, Eric W. -F. Lam, Peng Gao, Bilian Jin, Ruoyu Wang
Summary: The ADO/hypotaurine axis plays a crucial role in driving the self-renewal and maintenance of glioma 'cancer stem cells' or glioma cancer stem-like cells. Inhibiting this metabolic pathway may limit glioblastoma cell proliferation and tumor growth.
CELL DEATH DISCOVERY
(2021)
Article
Immunology
Oscar Badillo-Godinez, Adolfo Pedroza-Saavedra, Veronica Valverde-Garduno, Victor Bermudez-Morales, Minerva Maldonado-Gama, Ricardo Leon-Letelier, Laura C. Bonifaz, Fernando Esquivel-Guadarrama, Lourdes Gutierrez-Xicotencatl
Summary: The study demonstrated that targeting 16E5 to DEC-205 induced a strong protective immune response, with 70% of mice controlling tumor growth and surviving. It also generated 16E5-specific memory T cells and delayed tumor growth.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Adolfo Pedroza-Saavedra, Angelica Nallelhy Rodriguez-Ocampo, Azucena Salazar-Pina, Aislinn Citlali Perez-Morales, Lilia Chihu-Amparan, Minerva Maldonado-Gama, Aurelio Cruz-Valdez, Fernando Esquivel-Guadarrama, Lourdes Gutierrez-Xicotencatl
Summary: Antibodies against VLPs-16/18 are effective in detecting HPV-vaccinated women, while antibodies against L1-16 are better at differentiating the CIN3/CC group. Larger population studies are needed to validate these results.
Article
Oncology
Josep Guma, Jose Adria-Cebrian, Belen Ruiz-Aguado, Cinta Albacar, Josefa Girona, Ricardo Rodriguez-Calvo, Neus Martinez-Micaelo, Eric W. F. Lam, Luis Masana, Sandra Guaita-Esteruelas
Summary: The study identified a positive association between TG-enriched particles and certain branched amino acids with breast cancer, suggesting a distinct metabolic signature in BC patients that could aid in improved stratification and treatment. This is the first time advanced NMR profiling has been used to identify relevant lipid and amino acid metabolites in BC serum samples for early and reliable diagnosis and prognosis.
Article
Multidisciplinary Sciences
Rui Gao, He Bin, Qitao Huang, Zifeng Wang, Min Yan, Eric Wing-Fai Lam, Suxia Lin, Bo Wang, Quentin Liu
Summary: The presence of immune transcripts in cancer cells increases during malignant transformation, contributing to different prognoses of immune gene signatures. An optimized immune response signature, obtained by excluding cancer-related immune genes, offers more reliable prognostic value and reveals favorable associations with antigen presentation, NK cell killing, and T cell signaling. Higher expression of this signature is associated with better responses to immunotherapy and predicts favorable prognosis, providing insights into cancer cell plasticity and the tumor microenvironment.
Article
Oncology
Vivian Weiwen Xue, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Travis Hoi-Wai To, Justin Shing-Yin Chung, Francis Mussal, Eric W-F Lam, Chunjie Li, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: The study demonstrates the development of a novel gene therapeutic approach targeting Mincle in a tumor-specific manner using the USMB system. The strategy effectively inhibits protumoral effects in mouse and human macrophages, showing potential for clinical translation in cancer treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Jose Adria-Cebrian, Sandra Guaita-Esteruelas, Eric W. -F. Lam, Marta Rodriguez-Balada, Jordi Capellades, Josefa Girona, Ana Maria Jimenez-Santamaria, Oscar Yanes, Luis Masana, Josep Guma
Summary: This study demonstrates the importance of tumor microenvironment crosstalk, the crucial role of lipid transfer between adipose tissue and cancer cells, and the specific lipid signature of each breast cancer subtype. Different breast cancer cell lines metabolize lipids in different ways, with drug resistant cells showing a metabolic pattern more similar to triple negative breast cancer cells. Understanding these lipid patterns may be helpful in breast cancer diagnosis and developing targeted treatments.
Article
Biochemistry & Molecular Biology
Changxu Wang, Qilai Long, Qiang Fu, Qixia Xu, Da Fu, Yan Li, Libin Gao, Jianming Guo, Xiaoling Zhang, Eric W-F Lam, Judith Campisi, Yu Sun
Summary: The soluble factor EREG, produced by senescent stromal cells, plays a crucial role in the development and malignant progression of cancer cells in the tumor microenvironment. Targeting EREG in treatment-damaged TME significantly improves cancer therapeutic efficacy and shows potential value in translational medicine.
Article
Multidisciplinary Sciences
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze -Hang Ng, Eric W. -F Lam, Dongmei Zhang, Yi-Ping Ho, Ka-Fai To, Kam -Tong Leung, Xiaohua Jiang, Ho Ko, Tin -Lap Lee, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: This study discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis, which contributes to a better understanding of tumor innervation. The study also identified a phenomenon of macrophage to neuron-like cell transition (MNT) and identified a crucial regulator for MNT. This finding has potential clinical significance for the treatment of cancer pain.
Article
Multidisciplinary Sciences
Weiyingqi Cui, Ning Xie, Eric W. -F. Lam, Victoria Hahn-Stromberg, Na Liu, Hong Zhang, Xiao-Feng Sun
Summary: Accumulating evidence suggests the important roles of FOXO3, FOXM1, and SIRT6 in cancer progression. This study investigates the expression and clinical significance of these proteins in rectal cancer patients undergoing radiotherapy (RT). The results show that FOXO3 and FOXM1 are mainly expressed in the cytoplasm, while SIRT6 is expressed in both the cytoplasm and nucleus. FOXO3 expression increases with tumor progression, while SIRT6 expression decreases. High FOXO3 expression is associated with late TNM stage, distant metastasis, and poor prognosis in RT patients. Genetic analysis implicates DNA methylation in FOXO3 overexpression. Functional enrichment analysis reveals the involvement of FOXO3 in metabolism-related signaling pathways and radioresistance. In conclusion, FOXO3 may serve as a prognostic factor in rectal cancer patients undergoing RT.
Review
Biotechnology & Applied Microbiology
Giampaolo Calissi, Eric W. -F. Lam, Wolfgang Link
Summary: FOXO proteins are transcription factors that are involved in regulating stress responses to maintain cellular homeostasis. Dysregulation of FOXO protein functions contributes to cardiovascular disease, cancer, diabetes, and neurological diseases. This review summarizes the biology of FOXO proteins, their roles in disease and longevity, and discusses pharmacological approaches to develop FOXO-targeting therapeutics.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
