期刊
VIROLOGY
卷 404, 期 2, 页码 225-230出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.05.004
关键词
CD8(+) T cell; IL-10; Respiratory tract; Virus infection
类别
资金
- Public Health Service [F32 AI540932, R01 HL071985]
- NIH [P01 AI060642]
It has become clear that T cells with the potential to negatively regulate the immune response are normal constituents of the immune system. These cells often mediate their effects through the production of immunosuppressive factors. At present our understanding of how these cells are generated is limited. Here we report the presence of a population of IL-10-producing, virus-specific CD8(+) T cells in the lungs of mice following acute respiratory infection. These cells were only found at minimal levels in the spleen and draining lymph node; instead they were restricted primarily to the infected lung tissue. A major finding from this study is demonstration that the ability to produce IL-10 can be acquired by IFN gamma-producing effector cells following entry into the infected lung. These studies suggest IL-10 production is the result of further differentiation of an antigen-specific CD8(+)T cell that is governed by signals present in infected lung tissue. (C) 2010 Elsevier Inc. All rights reserved.
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