Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, Research & Experimental
Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim, Soo-Youn Lee
Summary: Proteomic analysis revealed changes in transthyretin and TBG levels in MDD patients, which also changed after antidepressant treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Psychiatry
Andrew J. Cutler, Gregory W. Mattingly, Vladimir Maletic
Summary: The pathophysiology of major depressive disorder is associated with impaired connectivity in key brain networks, which involves the GABAergic system of neurotransmission. Defects in GABA and neuroactive steroids (NASs) have been observed in adults with depression, and treatment with antidepressants can normalize these levels. There is interest in using NAS GABA(A) receptor positive allosteric modulators (PAMs) as potential treatments for depression, with brexanolone, zuranolone, and PH10 showing promise in clinical development. These NASs may provide novel and effective treatments for patients with major depressive disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Kai Sun, Xianli Wang
Summary: This study investigated the use and trends of drugs for postpartum depression (PPD) in nine cities across China from 2016 to 2020. The results showed an increase in the number of PPD patients and total prescription amount during this five-year period. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) were the main drugs used for PPD treatment. The centralized drug-procurement policy in China has led to a significant reduction in drug costs, relieving the economic burden on patients.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, Research & Experimental
Daniela Muresan, Septimiu Voidazan, Andreea Salcudean, Cristina Raluca Bodo, Iosif Gabos Grecu
Summary: This study aimed to evaluate the effectiveness of bioresonance therapy in improving the severity of recurrent depressive disorder. Results showed that bioresonance therapy was more effective than selective serotonin reuptake inhibitor medication in reducing the severity of depression in patients with moderate and mild episodes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Obstetrics & Gynecology
Emelie Wolgast, Caroline Lilliecreutz, Gunilla Sydsjo, Marie Bladh, Ann Josefsson
Summary: The study found that women with major depressive disorder (MDD) diagnosed before pregnancy and who had used antidepressants before or during pregnancy were at increased risk for adverse obstetric and neonatal outcomes compared to women without MDD. These risks included operative childbirth, neonatal intensive care unit (NICU) admissions, preterm birth, and low birthweight. Women who continued antidepressant medication during pregnancy had somewhat higher risks for adverse outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Psychiatry
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, Soren Dinesen Ostergaard
Summary: This study analyzed patient-level data to assess the relationship between antidepressant side effects and HDRS-17 ratings, finding that some HDRS-17 items are associated with common antidepressant side effects, potentially leading to an underestimation of antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
R. Seiger, G. Gryglewski, M. Kloebl, A. Kautzky, G. M. Godbersen, L. Rischka, T. Vanicek, M. Hienert, J. Unterholzner, L. R. Silberbauer, P. Michenthaler, P. Handschuh, A. Hahn, S. Kasper, R. Lanzenberger
Summary: This study found that rapid WM microstructure adaptations within 1 hour after i.v. SSRI administration precede elevations in mood due to SSRI treatment, adding a new facet to the complex mode of action of antidepressant therapy.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Hematology
Sanne Bakker, Johanna Louise I. Burggraaf, Marieke J. H. A. Kruip, Felix J. M. van der Meer, Willem M. Lijfering, Nienke van Rein
Summary: Selective serotonin reuptake inhibitors (SSRIs) may increase the risk of major bleeding, particularly for CYP2C9-inhibiting SSRIs, by affecting platelet function and VKA metabolism. The use of SSRIs is associated with an increased risk of a high INR, indicating potential bleeding complications.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan, Mark K. Santillan
Summary: Depression and preeclampsia are bi-directionally associated with each other, and SSRIs may attenuate the risk of preeclampsia. This study found that SSRIs use was associated with decreased risk of preeclampsia and reduced copeptin levels in early pregnancy, suggesting a potential therapeutic effect.
REPRODUCTIVE SCIENCES
(2023)
Article
Cell Biology
Shanshan Li, Yinquan Fang, Yihe Zhang, Mengmeng Song, Xilin Zhang, Xiao Ding, Hang Yao, Miaomiao Chen, Yiming Sun, Jianhua Ding, Qin Wang, Ming Lu, Guangyu Wu, Gang Hu
Summary: This study reveals the involvement of neurotoxic reactive astrocytes and microglial NLRP3 inflammasome in depression. Knockout of Nlrp3 in microglial cells alleviates the induction of A1-like astrocytes and improves neuronal dysfunction. The NF-KB pathway and caspase-1 activation play crucial roles in the production of A1-like astrocytes.
Article
Cell Biology
Karolina Kriauciunaite, Aida Kausyle, Justina Pajarskiene, Virginijus Tunaitis, Dmitry Lim, Alexei Verkhratsky, Augustas Pivoriunas
Summary: This study reveals impaired capacity of immortalized hippocampal astrocytes from 3xTG-AD mice to support BBB integrity in vitro, through paracrine mechanisms, which may represent an important factor underlying vascular abnormalities during the development of AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Augustas Pivoriunas, Alexei Verkhratsky
Summary: The evolution of the blood-brain barrier is closely related to the centralization of the nervous system. Different animals have different ways of forming barriers, with the vertebrates having an endothelial barrier secured by tight and adherent junctions. Astrocytes communicate with endothelial cells through secretion, regulating the integrity of the blood-brain barrier.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Paula Ramos-Gonzalez, Susana Mato, Juan Carlos Chara, Alexei Verkhratsky, Carlos Matute, Fabio Cavaliere
Summary: The study showed that astrocytes derived from Parkinson's disease patients have significant defects, including decreased complexity, abnormal mitochondria, and increased oxidative stress, which may contribute to neuronal death.
NPJ PARKINSONS DISEASE
(2021)
Article
Biology
Marcus Augusto-Oliveira, Gabriela P. Arrifano, Charlotte Isabelle Delage, Marie-Eve Tremblay, Maria Elena Crespo-Lopez, Alexei Verkhratsky
Summary: Microglial cells, originating from foetal macrophages, undergo phenotypic metamorphosis in response to the nervous tissue environment, displaying high plasticity and heterogeneity in gene and protein expression; their surveilling functions are crucial for maintaining homeostasis and contributing to the adaptive capacity of the central nervous system.
BIOLOGICAL REVIEWS
(2022)
Editorial Material
Cell Biology
Alexei Verkhratsky, Alexey Semyanov
Article
Biochemistry & Molecular Biology
Ya-Fei Zhao, Wen-Jing Ren, Ying Zhang, Jin-Rong He, Hai-Yan Yin, Yang Liao, Patrizia Rubini, Jan M. Deussing, Alexei Verkhratsky, Zeng-Qiang Yuan, Peter Illes, Yong Tang
Summary: This study suggests that P2X7 receptors in hippocampal astrocytes are involved in the development of depressive disorder, and microglia and astrocytes respond differently to stress stimuli.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Alexei Verkhratsky, Margaret S. Ho, Vladimir Parpura, Aleksandra Pekowska
Summary: The evolution of the nervous system involved cellular diversification and specialization of functions, with the emergence of the centralized nervous system leading to an increase in the complexity of neuroglia. In the primate brain, especially in humans, the astrocyte lineage is exceedingly complex, possibly facilitating interlayer communication and integration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Robert Zorec, Alexei Verkhratsky
Summary: Astrocytes are key homeostasis providing cells in the central nervous system, and their alterations are associated with diseases caused by infectious insults. Neurotropic infections, including COVID-19 and other viruses, activate astrocytes and utilize their metabolic characteristics for viral multiplication. However, the failure of astrocyte protection in certain circumstances remains a topic for future study.
ESSAYS IN BIOCHEMISTRY
(2023)
Review
Physiology
Chia-Yu Yeh, Kuan-Yu Wu, Guo-Jen Huang, Alexei Verkhratsky
Summary: Adult neurogenesis is an important process that contributes to adaptive network remodelling in the brain. This review focuses on the cellular characteristics and roles of radial astrocytes (RSA) and parenchymal astrocytes in adult neurogenesis in different brain regions. The potential therapeutic applications of RSA and astrocytes in cell replacement and regeneration strategies are also discussed.
Editorial Material
Physiology
Alan Alpar, Alexei Verkhratsky
Article
Biochemistry & Molecular Biology
Xinyu Li, Binjie Chen, Dianjun Zhang, Siman Wang, Yuliang Feng, Xiafang Wu, Lulu Cui, Ming Ji, Wenliang Gong, Alexei Verkhratsky, Maosheng Xia, Baoman Li
Summary: A novel mouse model of mania was developed by exposing mice to chronic unpredictable rhythm disturbances (CURD), including disruption of circadian rhythm, sleep deprivation, exposure to bright light, and other stressors. The CURD mice exhibited manic behaviors similar to those observed in patients with manic syndrome. Treatment with LiCl and valproic acid improved behaviors and molecular indicators in the manic mice. This environment-based model provides a valuable tool for studying the neuropathological mechanisms of mania.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Si-Si Lin, Bin Zhou, Bin-Jie Chen, Ruo-Tian Jiang, Baoman Li, Peter Illes, Alexey Semyanov, Yong Tang, Alexei Verkhratsky
Summary: This study found that electroacupuncture can prevent atrophy of astrocytes in the prefrontal cortex, and alleviate depressive-like behavior induced by chronic unpredictable mild stress. These behavioral changes are associated with morphological atrophy of astrocytes and down-regulation of the protein Ezrin.
CELL DEATH & DISEASE
(2023)
Editorial Material
Cell Biology
Alexei Verkhratsky, Alexey Semyanov
Summary: Lia et al. discovered the critical role of the STIM1 ER Ca2+ sensor in the functional decline of astrocytes in AD-like pathology in PS2APP mice. The downregulation of STIM1 expression in astrocytes resulted in decreased ER Ca2+ content and impaired astrocytic Ca2+ signaling, leading to synaptic and memory deficits. Overexpression of STIM1 in astrocytes restored Ca2+ excitability and improved synaptic and memory function.
Review
Neurosciences
Chenju Yi, Alexei Verkhratsky, Jianqin Niu
Summary: Adult oligodendrocyte precursor cells (aOPCs), derived from fetal OPCs, are unique neuroglia cells in the central nervous system (CNS) and have diverse roles in neurological diseases. This review presents the physiology of aOPCs and summarizes the beneficial and detrimental effects of aOPCs in different CNS diseases. The paper discusses aOPC death, reactivity, changes during senescence, interactions with other glial cells, and pathological remodeling during disease, and outlines future perspectives for studying aOPCs in brain pathologies for potential therapeutic strategies.
TRENDS IN NEUROSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alexei Verkhratsky, Arthur Butt, Baoman Li, Peter Illes, Robert Zorec, Alexey Semyanov, Yong Tang, Michael V. Sofroniew
Summary: This article introduces the pathophysiology of astroglial cells in neurological diseases and disorders, discussing their changes and functions in different pathological states, and proposes the identification of cellular and molecular mechanisms of astroglial pathophysiology as a new frontier for finding novel therapeutic strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
