期刊
VIROLOGY
卷 395, 期 1, 页码 143-151出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.09.003
关键词
Punta Toro virus; Interferon; Phlebovirus; Rift Valley fever virus; Rift Valley fever; Hemorrhagic fever
类别
资金
- Virology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health [N01-AI-15435, NO1-AI-30063]
- Utah State University Center for Integrated BioSystems Graduate Support Program
The Adames strain of Punta Toro virus (PTV-A, Bunyaviridae, Phlebovirus) causes an acute lethal disease in hamsters and mice. The Balliet strain of the virus (PTV-B) is generally considered to be avirulent. The difference in hamster Susceptibility is likely due to the ability of PTV-A to suppress interferon (IFN)-beta similarly to that described for Rift Valley fever virus. Here we investigated strain differences in PTV pathogenesis and the IFN response in mice. Although PTV-B infection in mice did not induce systemic IFN-beta release, primary macrophages produced dramatically higher levels when exposed to the virus in culture. The importance of IFN in resistance to PTV infection was borne out in studies employing STAT-I knock-out mice. Also, a number of genes specific to IFN response pathways were upregulated in PTV-B-infected macrophages. Our findings provide new insights into the type I IFN response during PTV infection in the mouse model of phleboviral disease. (C) 2009 Elsevier Inc. All rights reserved.
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