期刊
VIROLOGY
卷 390, 期 1, 页码 139-150出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.04.026
关键词
Tick-borne encephalitis virus; Mouse model; Mortality; Peripheral infection; Central nervous system pathology; Systemic inflammation; Systemic stress response
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [19780230]
- Ministry of Health, Labour and Welfare, Japan [LSHG-CT2004-511960]
- Natural Environment Research Council [CEH010021] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [19780230] Funding Source: KAKEN
Tick-borne encephalitis virus (TBEV) induces acute central nervous system (CNS) disease in humans In this. Study, we investigate the pathogenetic mechanisms that correlate with fatal infection with TBEV in a mouse model. Following subcutaneous infection with high challenge doses (>10(7) PFU), mice started to die early (8 days) and mortality rates reached >80%. These doses induced acute and widespread infection of the CNS. On the other hand, following subcutaneous infection with low challenge doses (10(2)-10(6) PFU), mice started to die late (11 days) and approximately one half of the mice survived but exhibited degrees of encephalitis similar to dying mice. However, low dose dying mice exhibited severe systemic stress response, and increased levels of TNF-alpha compared with recovering mice. We therefore conclude that in addition to the development of CNS disease, systemic inflammatory and stress responses contribute to induce a fatal infection following subcutaneous infection of mice with TBEV. (C) 2009 Elsevier Inc All rights reserved.
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