期刊
VIROLOGY
卷 386, 期 1, 页码 6-11出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.01.003
关键词
HTLV; Tax; CREB; NF-kappa B; Ubiquitination; Sumoylation; Nuclear bodies
类别
资金
- MIUR PRIN
- Belgian Fonds National de la Recherche Scientifique
- Internationale Brachet Stiftung
HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappa B. as has been previously demonstrated for Tax-1 (c) 2009 Elsevier Inc. All rights reserved.
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