What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

(2015) Lu Huo et al.   Nature Communications

Genentech dives deeper into the next wave of cancer immunotherapies

(2014) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling

(2014) Lu Huo et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Heme-dependent dioxygenases in tryptophan oxidation

(2013) Jiafeng Geng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Power of Two

(2013) Lu Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression

(2013) Andrew H Miller   NEUROPSYCHOPHARMACOLOGY

Ring-Cleaving Dioxygenases with a Cupin Fold

(2012) Susanne Fetzner   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

An expanding range of targets for kynurenine metabolites of tryptophan

(2012) Trevor W. Stone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

My life with tryptophan-Never a dull moment

(2010) Osamu Hayaishi   PROTEIN SCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY