期刊
VIROLOGY
卷 376, 期 2, 页码 330-338出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.04.004
关键词
bacteriophage; virion proteins; RNA polymerase; accelerated divergence
类别
资金
- NIGMS NIH HHS [GM24365, R01 GM024365, R01 GM024365-25] Funding Source: Medline
Pseudomonas chlororaphis phage 201 phi 2-1 is a relative of Pseudomonas aeruginosa myovirus ( KZ. Phage 201 phi 2-1 was examined by complete genomic sequencing (316,674 bp), by a comprehensive mass spectrometry survey of its virion proteins and by electron microscopy. Seventy-six proteins, of which at least 69 have homologues in ( KZ, were identified by mass spectrometry. Eight proteins, in addition to the major head, tail sheath and tail tube proteins, are abundant in the virion. Electron microscopy of 201 phi 2-1 revealed a multitude of long, fine fibers apparently decorating the tail sheath protein. Among the less abundant virion proteins are three homologues to RNA polymerase beta or beta' subunits. Comparison between the genomes of 201 phi 2-1 and phi KZ revealed substantial conservation of the genome plan, and a large region with an especially high rate of gene replacement. The phi KZ-like phages exhibited a two-fold higher rate of divergence than for T4-like phages or host genomes. (C) 2008 Elsevier Inc. All rights reserved.
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