Article
Virology
Elina Vaisanen, Inka Kuisma, Marjaana Makinen, Jorma Ilonen, Riitta Veijola, Jorma Toppari, Klaus Hedman, Maria Soderlund-Venermo
Summary: Human torque teno viruses (TTVs) are common nonenveloped viruses found in human blood, with infections primarily occurring during the first two years after birth. There is significant individual variation in viral load and strain diversity during the infection process.
Article
Multidisciplinary Sciences
Kuang-Liang Hsiao, Li-Yu Wang, Ju-Chien Cheng, Yu-Jung Cheng, Chiung-Ling Lin, Hsin-Fu Liu
Summary: TTV group 6, a recently discovered phylogenetic group, was found to be prevalent in both Taiwanese general population and eastern Taiwan indigenes, showing a high degree of diversity.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Pediatrics
Yifat Eldar-Yedidia, Efrat Ben-Shalom, Miriam Hillel, Ruth Belostotsky, Orli Megged, Yossi Freier-Dror, Yaacov Frishberg, Yechiel Schlesinger
Summary: This study found that children with low TTV and total AV titers 5-6 months post-transplantation are at increased risk for graft rejection within a year after transplantation.
PEDIATRIC NEPHROLOGY
(2022)
Article
Virology
Marie-Celine Zanella, Diem-Lan Vu, Krisztina Hosszu-Fellous, Dionysios Neofytos, Chistian Van Delden, Lara Turin, Antoine Poncet, Federico Simonetta, Stavroula Masouridi-Levrat, Yves Chalandon, Samuel Cordey, Laurent Kaiser
Summary: Metagenomics identified previously unrecognized viruses in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients, highlighting their potential as sources of infection. This observational cohort study aimed to investigate the prevalence and dynamics of DNA and RNA viruses in the plasma of allo-HSCT recipients for one year post-transplant. TTV infection was observed in 97% of patients, followed by HPgV-1 (prevalence: 26-36%). Viral loads for TTV and HPgV-1 peaked at month 3. Multiple Polyomaviridae viruses were detected in over 10% of patients. HPyV6 and HPyV7 had a prevalence of 27% and 12% respectively at month 3, while CMV had a prevalence of 27%. The other viruses had low prevalence rates, and co-infections were observed in 72% of patients at month 3. Further research is needed to understand the relationship between these viral infections, immune reconstitution, and clinical outcomes.
Article
Virology
Aline L. van Rijn, Herman F. Wunderink, Igor A. Sidorov, Caroline S. de Brouwer, Aloysius C. M. Kroes, Hein Putter, Aiko P. J. de Vries, Joris Rotmans, Mariet C. W. Feltkamp
Summary: The dynamics of TTV load predict allograft rejection in kidney transplantation recipients, but not BKPyV and CMV infections. Further validation is needed to explore the potential use of TTV load levels as a guide for optimal immunosuppressive drug dosage to prevent allograft rejection.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Pediatrics
Phoebe Uhl, Andreas Heilos, Gregor Bond, Elias Meyer, Michael Boehm, Elisabeth Puchhammer-Stoeckl, Klaus Arbeiter, Thomas Mueller-Sacherer, Dagmar Csaicsich, Christoph Aufricht, Krisztina Rusai
Summary: TTV viral load is associated with the strength of immunosuppression in kidney-transplanted patients, making it a potential tool for monitoring IS in order to evaluate clinical outcomes.
PEDIATRIC NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Henry E. Miller, Daniel Montemayor, Janet Li, Simon A. Levy, Roshan Pawar, Stella Hartono, Kumar Sharma, Bess Frost, Frederic Chedin, Alexander J. R. Bishop
Summary: R-loops are structures formed by the hybridization of RNA and DNA, and extensive research has been conducted in recent years, resulting in a large number of datasets. However, current databases provide limited access to these data, and there are no web tools available for analyzing user-supplied R-loop datasets. In this study, we reprocessed 810 R-loop samples to create the largest R-loop data resource to date. We also developed a framework and user-friendly database, RLBase, which allows users to explore public R-loop datasets, analyze their own data, and download standardized datasets.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Microbiology
Maria Cebria-Mendoza, Beatriz Beamud, Ivan Andreu-Moreno, Cristina Arbona, Luis Larrea, Wladimiro Diaz, Rafael Sanjuan, Jose M. Cuevas
Summary: This study found that Anelloviruses are widely present in the human body and are associated with age and gender. Analysis of global anellovirus diversity revealed that recombination is the main factor contributing to the diversity of these viruses.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Yanpeng Li, Le Cao, Xiao Han, Yingying Ma, Yanmei Liu, Shujun Gao, Chiyu Zhang
Summary: In this pilot exploratory study, the vaginal eukaryotic virome in women with different levels of cervical lesions was investigated using viral metagenomics. An altered eukaryotic virome was observed in women with different levels of lesions and Lacto-bacillus profiles. Anelloviruses and papillomaviruses were the most commonly detected eukaryotic viruses of the vaginal virome, and their abundance and diversity were associated with low-grade squamous intraepithelial lesion (LSIL) and cervical cancer (CC).
Article
Virology
Le Cao, Yingying Ma, Zhenzhou Wan, Bing Li, Weimin Tian, Chiyu Zhang, Yanpeng Li
Summary: Anelloviruses (AVs) are abundant in humans and are the most prevalent components of the commensal virome. Research on AV diversity, transmission, and persistence has mainly focused on adults, with limited understanding of the anellome in the respiratory tract of children. This study investigated the anellome profile and dynamics in the upper respiratory tract of children with acute respiratory tract infections (ARTIs). The findings suggest that betatorquevirus may decrease with age, while alphatorquevirus increases with age in childhood, and the individual respiratory anellome is unique and undergoes common replacement over time.
Article
Virology
Lorena Forque, Eliseo Albert, Estela Gimenez, Ignacio Torres, Nieves Carbonell, Jose Ferreres, Maria Luisa Blasco, David Navarro
Summary: This study found that monitoring plasma TTV DNA load may help predict the occurrence of severe nosocomial infections and mortality in critically ill COVID-19 patients.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Ting Peng, Yingping Hou, Haowei Meng, Yong Cao, Xiaotian Wang, Lumeng Jia, Qing Chen, Yang Zheng, Yujie Sun, Hebing Chen, Tingting Li, Cheng Li
Summary: A nucleolus Hi-C (nHi-C) experimental technique was developed to enrich nucleolus-associated chromatin interactions and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells. The research provides a global view of these interactions and demonstrates the important role of nucleoli in the organization of 3D genome architecture.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Raphael Forquet, Xuejiao Jiang, William Nasser, Florence Hommais, Sylvie Reverchon, Sam Meyer
Summary: This study presents the first transcriptomic map of a Dickeya species, which can significantly contribute to the field of phytopathogenicity. It also demonstrates the application of long-read Nanopore native RNA-seq in prokaryotes. The findings provide insights into the coordination of transcription in bacteria and suggest that gene expression is controlled at the level of transcription units rather than operons. The results have implications for microbial research and challenge the traditional operon model.
Article
Virology
Ying Liu, Hao Wang, Jie Yang, Jian Zeng, Guang-Ming Sun
Summary: Viral metagenomics was used to investigate viral nucleic acid in respiratory samples from 30 children with unknown etiological acute respiratory disease, identifying sequences related to anellovirus, coxsackievirus A4, and parechovirus. A phylogenetic analysis revealed a close relationship between anellovirus from this study and an unpublished anellovirus from a Vietnamese patient. The genome of coxsackievirus A4 showed high similarity to a strain identified in children with Hand, Foot, and Mouth Disease (HFMD). Further investigation is needed to determine the association of these viruses with specific respiratory diseases.
Article
Virology
Song-Yi Ning, Ming-Ming Zhou, Jie Yang, Jian Zeng, Jia-Ping Wang
Summary: This study identified two novel anelloviruses from fecal samples of experimental rats using viral metagenomic technique. The complete genomic sequences of these two anelloviruses were determined and fully characterized, expanding the genome diversity of anelloviruses and providing genetic background information of viruses existing in experimental rats.
Article
Public, Environmental & Occupational Health
Maria Wadl, Anette Siedler, Wolfgang Kraemer, Maria E. Haindl, Stephan Gebrande, Irene Krenn-Lanzl, Annette Mankertz, Wolfgang Hautmann
Article
Public, Environmental & Occupational Health
S. Gillesberg Lassen, M. Schuster, M. Stemmler, A. Steinmueller, D. Matysiak-Klose, A. Mankertz, S. Santibanez, O. Wichmann, G. Falkenhorst
EPIDEMIOLOGY AND INFECTION
(2014)
Article
Public, Environmental & Occupational Health
S. Borgmann, F. Schwab, S. Santibanez, A. Mankertz
EPIDEMIOLOGY AND INFECTION
(2014)
Article
Infectious Diseases
G. Necula, M. Lazar, A. Stanescu, A. Pistol, S. Santibanez, A. Mankertz, E. Lupulescu
Article
Microbiology
Julia R. Kessler, Jacques R. Kremer, Sergey V. Shulga, Nina T. Tikhonova, Sabine Santibanez, Annette Mankertz, Galina V. Semeiko, Elena O. Samoilovich, Jean-Jacques Muyembe Tamfum, Elisabeth Pukuta, Claude P. Muller
JOURNAL OF CLINICAL MICROBIOLOGY
(2011)
Article
Biotechnology & Applied Microbiology
Maria Woznik, Claudia Roedner, Ken Lemon, Bert Rima, Annette Mankertz, Tim Finsterbusch
JOURNAL OF GENERAL VIROLOGY
(2010)
Article
Immunology
Anette Siedler, Annette Mankertz, Fabian Feil, Gabriele Ahlemeyer, Angelika Hornig, Markus Kirchner, Konrad Beyrer, Johannes Dreesman, Sibylle Scharkus, Anne Marcic, Sabine Reiter, Dorothea Matysiak-Klose, Sabine Santibanez, Gerard Krause, Ole Wichmann
JOURNAL OF INFECTIOUS DISEASES
(2011)
Article
Immunology
Annette Mankertz, Mick N. Mulders, Sergey Shulga, Jacques R. Kremer, Kevin E. Brown, Sabine Santibanez, Claude P. Muller, Nina Tikhonova, Galina Lipskaya, Dragan Jankovic, Nino Khetsuriani, Rebecca Martin, Eugene Gavrilin
JOURNAL OF INFECTIOUS DISEASES
(2011)
Article
Immunology
Paul A. Rota, Kevin Brown, Annette Mankertz, Sabine Santibanez, Sergey Shulga, Claude P. Muller, Judith M. Huebschen, Marilda Siqueira, Jennifer Beirnes, Hinda Ahmed, Henda Triki, Suleiman Al-Busaidy, Annick Dosseh, Charles Byabamazima, Sheilagh Smit, Chantal Akoua-Koffi, Josephine Bwogi, Henry Bukenya, Niteen Wairagkar, Nalini Ramamurty, Patcha Incomserb, Sirima Pattamadilok, Youngmee Jee, Wilina Lim, Wenbo Xu, Katsuhiro Komase, Makoto Takeda, Thomas Tran, Carlos Castillo-Solorzano, Paul Chenoweth, David Brown, Mick N. Mulders, William J. Bellini, David Featherstone
JOURNAL OF INFECTIOUS DISEASES
(2011)
Article
Immunology
Hedwig Roggendorf, Sabine Santibanez, Annette Mankertz, Ulrich van Treeck, Michael Roggendorf
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2012)
Article
Multidisciplinary Sciences
Christina Poethko-Mueller, Annette Mankertz
Article
Immunology
Christina Poethko-Mueller, Annette Mankertz
Article
Immunology
Sally A. Baylis, Tim Finsterbusch, Norbert Bannert, Johannes Bluemel, Annette Mankertz
Review
Virology
Annette Mankertz
Article
Immunology
Annette Mankertz, Zefira Mihneva, Hermann Gold, Sigrid Baumgarte, Armin Baillot, Rudolph Helble, Hedwig Roggendorf, Golubinka Bosevska, Jasminka Nedeljkovic, Agata Makowka, Veronik Hutse, Heidemarie Holzmann, Stefan W. Aberle, Samuel Cordey, Gheorghe Necula, Andreas Mentis, Gulay Korukluoglu, Michael Carr, Kevin E. Brown, Judith M. Huebschen, Claude P. Muller, Mick N. Mulders, Sabine Santibanez
EMERGING INFECTIOUS DISEASES
(2011)
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
