期刊
VIROLOGY
卷 381, 期 1, 页码 16-21出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.08.040
关键词
Papillomavirus; Filopodia; Signaling; Keratinocyte; Cytoskeleton; Extracellular matrix
类别
资金
- NIH [CA085747, T32 A107538]
- American Cancer Society [192]
Human papillomaviruses (HPVs), etiological agents of epithelial tumors and cancers, initiate infection of basal human keratinocytes (HKs) facilitated by wounding. Virions bind to HKs and their secreted extracellular matrix (ECM), but molecular roles for Wounding or ECM binding during infection are unclear. Herein we demonstrate that HPV31 activates signals promoting cytoskeletal rearrangements and virion transport required for internalization and infection. Activation of tyrosine and PI3 kinases precedes induction of filopodia whereon virions are transported toward the cell body. Coupled with the loss of ECM-bound virions this supports a model whereby virus activated filopodial transport contributes to all increased and protracted virion uptake into Susceptible cells. (C) 2008 Elsevier Inc. All rights reserved.
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