期刊
VIROLOGY
卷 370, 期 2, 页码 228-236出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.10.005
关键词
rabies virus; hematophagous bat; rabies outbreak; molecular epidemiology; Augusto Correa municipality
类别
We genetically characterize rabies virus (RABV) strains isolated from human cases, domestic and wild animals during a human outbreak of bat-transmitted rabies in Augusto Correa municipality, Para state, Brazilian Amazon in 2005. Partial nucleotide sequences of the N gene (491 bp) were obtained for all strains, and phylogenetic analysis grouped these into two major clades (Para and Central-Southeast) and identified them as bat-related viruses genotype 1, Desmodus rotundus antigenic variant 3 (AgV3). A molecular clock was used to estimate the time of emergence for each RABV isolate. The molecular data from this study suggest the association of vampire bats with human and domestic animal cases reported in the outbreak, the circulation of at least two predominant lineages in the Para state, and also a geographic association to lineages dispersion. (c) 2007 Elsevier Inc. All rights reserved.
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