Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

(2015) James Andrew McCubrey et al.   Oncotarget

mTORC1 Inhibitors Suppress Meningioma Growth in Mouse Models

(2013) D. Pachow et al.   CLINICAL CANCER RESEARCH

Genetic changes with prognostic value in histologically benign meningiomas

(2013) Sandra Barbera et al.   CLINICAL NEUROPATHOLOGY

A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides

(2013) Georgia Levidou et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

(2013) Priscilla K Brastianos et al.   NATURE GENETICS

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

(2013) V. E. Clark et al.   SCIENCE

A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma

(2012) Penelope Korkolopoulou et al.   BJU INTERNATIONAL

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR -selected mouse thymocytes

(2012) G. W. Wong et al.   BLOOD

PTENgenomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity

(2012) Khalil Choucair et al.   BMC CANCER

Molecular alterations in meningiomas: association with clinical data

(2012) Dariusz J. Jaskolski et al.   CLINICAL NEUROPATHOLOGY

New insights into meningioma

(2012) Andrej Vranic et al.   CURRENT OPINION IN ONCOLOGY

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

(2012) J. S. Logue et al.   GENES & DEVELOPMENT

Phosphorylated 4E-binding protein 1 (p-4E-BP1): a novel prognostic marker in human astrocytomas

(2012) Penelope Korkolopoulou et al.   HISTOPATHOLOGY

Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer

(2012) Nuria Juanpere et al.   HUMAN PATHOLOGY

PTEN regulation of ERK1/2 signaling in cancer

(2012) Mahandranauth A. Chetram et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

(2012) S. Mueller et al.   NEURO-ONCOLOGY

Notch1 expression is upregulated in glioma and is associated with tumor progression

(2011) Ligang Jiang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Radiotherapy for atypical meningiomas

(2011) Richard Mair et al.   JOURNAL OF NEUROSURGERY

ERK Crosstalks with 4EBP1 to Activate Cyclin D1 Translation during Quinol-Thioether–Induced Tuberous Sclerosis Renal Cell Carcinoma

(2011) Jennifer D. Cohen et al.   TOXICOLOGICAL SCIENCES

Expression of pERK and pAKT in human astrocytomas: correlation with IDH1-R132H presence, vascular endothelial growth factor, microvascular characteristics and clinical outcome

(2011) Angelica A. Saetta et al.   VIRCHOWS ARCHIV

PI3K and STAT3: A New Alliance

(2011) P. K. Vogt et al.   Cancer Discovery

Low-Level Amplification of Oncogenes Correlates Inversely with Age for Patients with Nontypical Meningiomas

(2011) Marie E. Beckner et al.   World Neurosurgery

Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers

(2010) Sunil Badve et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer

(2010) Sara M. Johnson et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

The effect on radioresistance of manganese superoxide dismutase in nasopharyngeal carcinoma

(2010) Zhao   ONCOLOGY REPORTS

Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas

(2009) Hyeon Seok Eom et al.   ACTA ONCOLOGICA

The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray

(2009) Li Xiao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fibroblast growth factor receptor–3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase–Akt pathway

(2009) Mahlon D. Johnson et al.   JOURNAL OF NEUROSURGERY

Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas

(2008) Yoh Dobashi et al.   CANCER

Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

(2008) Mahlon D. Johnson et al.   JOURNAL OF NEURO-ONCOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE