Article
Biochemistry & Molecular Biology
Johannes Wolf, Edith Willscher, Henry Loeffler-Wirth, Maria Schmidt, Gunter Flemming, Marlen Zurek, Holm H. Uhlig, Norman Handel, Hans Binder
Summary: This study provides a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of children and adolescents with active CD, revealing three distinct CD patient groups. The persistence of symptoms was weakly associated with subgroups, with the CD-high group showing the highest marsh stages and cell cycle rates, indicating virtually complete villous atrophy. Inflammation-level differences between subgroups were further deciphered into immune cell types using cell type de-convolution. The application of self-organizing maps provided high-resolution landscapes of the CD-transcriptome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Fernando Fernandez-Banares, Sergio Farrais, Montserrat Planella, Josefa Melero, Natalia Lopez-Palacios, Santiago Vivas, Luis Fernandez-Salazar, Ana Pilar Lanzarote, Pablo Ruiz-Ramirez, Marta Aguilar-Criado, Judith Vidal, Aureli Esquerda, Cristina Serrano, Concepcion Nunez
Summary: Age affects the sensitivity of intraepithelial lymphocyte cytometric patterns in coeliac disease diagnosis, with patients aged 70 years and older having lower TCR gamma delta+ counts, and a cutoff of >10% being more accurate than >14%.
Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni Casella, Carlo Catassi, Carolina Ciacci, Delia Gabriela Apostol Ciobanu, Simon S. Cross, Mihai Danciu, Prasenjit Das, Rachele Del Sordo, Michael Drage, Luca Elli, Alessio Fasano, Ada Maria Florena, Nicola Fusco, James J. Going, Stefano Guandalini, Catherine E. Hagen, David T. S. Hayman, Sauid Ishaq, Hilary Jericho, Melanie Johncilla, Matt Johnson, Katri Kaukinen, Adam Levene, Sarah Liptrot, Laura Lu, Govind K. Makharia, Sherly Mathews, Giuseppe Mazzarella, Roxana Maxim, Khun La Win Myint, Hamid Mohaghegh-Shalmani, Afshin Moradi, Chris J. J. Mulder, Ronnie Ray, Chiara Ricci, Mohammad Rostami-Nejad, Anna Sapone, David S. Sanders, Juha Taavela, Umberto Volta, Marjorie Walker, Mohammad Derakhshan
Summary: The histological changes in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) show distinct alterations consistent with an intestinal response to luminal antigens, even at the Marsh 0 stage of villus architecture.
Article
Immunology
Ariana Diaz, Luciano D'Attilio, Federico Penas, Bettina Bongiovanni, Estefania Massa, Agata Cevey, Natalia Santucci, Oscar Bottasso, Nora Goren, Maria Luisa Bay
Summary: Tuberculosis (TB) is a health problem characterized by an immuno-endocrine imbalance. Glucocorticoids (GC) and peroxisome proliferator-activated receptors (PPARs) play important roles in counteracting inflammation. This study investigates the contribution of PPAR gamma in immunoendocrine-metabolic interactions in TB patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michal Kori, Yonatan Zamir, Sami Or Yermiyahu, Inessa Ainbinder, Svetlana Daichman, Gavriel David Pinto, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Natan Lederman, Eran Matz, Raanan Shamir, Iris Dotan, Dan Turner
Summary: This study found that the prevalence of coeliac disease (CeD) and coeliac autoimmunity (CeA) is higher in patients with inflammatory bowel diseases (IBD), especially in paediatric-onset IBD and Crohn's disease (CD). The diagnosis of CeD usually precedes the diagnosis of IBD, and patients with both IBD and CeD receive more intensified treatment for IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Immunology
Hongbo Zhang, Taylor Alford, Shuangquan Liu, Dongming Zhou, Jieru Wang
Summary: Influenza virus infection decreases the expression of PPAR gamma in macrophages, leading to inflammation and lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Sara Bacchi, Federico Biagi, Simona Panelli, Elena Betti, Gino Roberto Corazza, Enrica Capelli, Rachele Ciccocioppo
Summary: Untreated coeliac disease patients with iron deficiency anemia demonstrated a pro-inflammatory shift in their duodenal microbiota, while coeliac patients on a strict GFD with persistent diarrhea exhibited differences in duodenal microbiota composition compared to those with other types of persistent symptoms.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Nutrition & Dietetics
Anna Szaflarska-Poplawska, Aleksandra Dolinska, Magdalena Kusmierek
Summary: The aim of this study was to evaluate nutritional imbalances in children with coeliac disease (CD) on a strict gluten-free diet (GFD). The results showed that children with CD had lower levels of folic acid and vitamin B-1, lower calcium levels, and lower intake of calcium, folic acid, and vitamin D compared to dietary recommendations. However, their intake of proteins and carbohydrates exceeded the recommended levels. Additionally, a significantly higher number of CD children were classified as underweight.
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Clemens Kamrath, Sascha R. Tittel, Desiree Dunstheimer, Elke Froehlich-Reiterer, Markus Freff, Claudia Boettcher, Nadine Scheffler, Stefanie Lenze, Elke Gericke, Susanne Thiele, Reinhard W. Holl
Summary: The study aims to analyze whether the confirmation of coeliac disease can be postponed in children with new-onset type 1 diabetes and positive screening results.
Article
Cell Biology
Claire Bryant, Amy Webb, Alexander S. Banks, Dawn Chandler, Rajgopal Govindarajan, Shipra Agrawal
Summary: Podocytes are specialized epithelial cells that play a crucial role in maintaining kidney function. They express specific variants of the PPAR gamma gene, which are different from those found in adipose tissue. Understanding these podocyte-specific PPAR gamma variants could lead to the development of targeted therapeutic treatments.
Article
Medicine, General & Internal
Thomas Inns, Kate M. Fleming, Miren Iturriza-Gomara, Daniel Hungerford
Summary: A cohort study in the UK found that rotavirus vaccination was not associated with the prevention of coeliac disease (CD) or type 1 diabetes (T1D) in children.
Article
Medicine, Research & Experimental
Domonkos Pap, Apor Veres-Szekely, Beata Szebeni, Reka Rokonay, Anna Onody, Rita Lippai, Istvan Marton Takacs, Andras Tisler, Magdolna Kardos, Franz Oswald, Andrea Fekete, Attila J. Szabo, Adam Vannay
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell Biology
Apor Veres-Szekely, Maria Bernath, Domonkos Pap, Reka Rokonay, Beata Szebeni, Istvan M. Takacs, Rita Lippai, Aron Cseh, Attila J. Szabo, Adam Vannay
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Medicine, Research & Experimental
Anna Onody, Apor Veres-Szekely, Domonkos Pap, Reka Rokonay, Beata Szebeni, Erna Sziksz, Franz Oswald, Gabor Veres, Aron Cseh, Attila J. Szabo, Adam Vannay
Summary: The study demonstrates increased IL-24 expression in serum and colon samples of children with IBD and DSS treated mice. Inflammatory factors such as IL-1 beta, LPS, and H2O2 can increase IL24 expression in PBMCs and LPMCs. IL-24 treatment promotes the expression of TGF-beta and PDGF-B in HT-29 cells, as well as enhances ECM-related gene expression and motility in CCD-18Co cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Rita Lippai, Apor Veres-Szekely, Erna Sziksz, Yoichiro Iwakura, Domonkos Pap, Reka Rokonay, Beata Szebeni, Gabor Lotz, Nora J. Beres, Aron Cseh, Attila J. Szabo, Adam Vannay
Summary: The research explored the complex and important role of PARK7 in intestinal inflammation related to gastrointestinal diseases, suggesting its potential as a therapeutic target in the future. Experimental findings indicated that PARK7 expression was higher in the mucosa of children with Crohn's disease, and influenced by various stimulating factors leading to changes in its synthesis level.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Apor Veres-Szekely, Domonkos Pap, Beata Szebeni, Laszlo Orfi, Csenge Szasz, Csenge Pajtok, Eszter Levai, Attila J. Szabo, Adam Vannay
Summary: Fibroblasts play a central role in diseases such as idiopathic pulmonary fibrosis. This study developed a cost-effective method to examine fibroblast migration and discussed the advantages of combining different functional assays in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Csenge Pajtok, Apor Veres-Szekely, Robert Agocs, Beata Szebeni, Peter Dobosy, Istvan Nemeth, Zoltan Vereb, Lajos Kemeny, Attila J. Szabo, Adam Vannay, Tivadar Tulassay, Domonkos Pap
Summary: The study found that high dietary salt intake results in increased dermal pro-inflammatory status, reduced expression of anti-inflammatory factors, and altered ECM synthesis and remodeling in the skin. High salt loading also decreased the production of IL10, IL13, and PDGFB in PBMCs. Additionally, in cultured dermal fibroblasts, high salt concentration led to decreased cell motility and ECM production.
Article
Cell Biology
Balint Balogh, Monika Vecsernyes, Apor Veres-Szekely, Gergely Berta, Alexandra Stayer-Harci, Oktavia Tarjanyi, Gyorgy Setalo
Summary: Urocortins can promote proliferation of MCF7 breast cancer cells via activation of ERK1/2 and reduce ATP production. This effect may be associated with the activation of urocortin receptors and the involvement of additional proteins such as PKA, PKB/Akt, MEK, p53, Rb, and E2F-1.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Domonkos Pap, Apor Veres-Szekely, Beata Szebeni, Adam Vannay
Summary: Inflammatory gastrointestinal diseases are closely related to neurodegenerative diseases such as Parkinson's and Alzheimer's. PARK7/DJ-1 plays a crucial role in maintaining gut microbiome and regulating intestinal inflammation, suggesting it as a potential therapeutic target for gut and brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Apor Veres-Szekely, Csenge Szasz, Domonkos Pap, Beata Szebeni, Peter Bokrossy, Adam Vannay
Summary: In the last 10 years, the relationship between dysbiosis and central nervous diseases has been proven. Microbial alterations lead to increased intestinal permeability, resulting in the penetration of bacterial fragments and toxins that induce local and systemic inflammatory processes, affecting distant organs including the brain. The integrity of the intestinal epithelial barrier plays a central role in the microbiota-gut-brain axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Domonkos Pap, Csenge Pajtok, Apor Veres-Szekely, Beata Szebeni, Csenge Szasz, Peter Bokrossy, Reka Zrufko, Adam Vannay, Tivadar Tulassay, Attila J. Szabo
Summary: Recent studies have shown that excessive salt intake can induce fibrotic changes in the peritoneum. This study aimed to better understand the underlying mechanisms. The results demonstrated that high-salt environments and increased osmolarity can lead to the production of inflammatory cytokines, profibrotic growth factors, and components of the renin-angiotensin-aldosterone system. Additionally, high salt was found to induce mesenchymal transition and increase extracellular matrix production. These findings contribute to our understanding of peritoneal fibrosis development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Transplantation
Eszter Levai, Apor Veres-Szekely, Conghui Zhang, Maria Bartosova, Domonkos Pap, Beata Szebeni, Iva Marinovic, Rebecca Herzog, Csenge Pajtok, Klaus Kratochwill, Sotirios Zarogiannis, Attila Szabo, Adam Vannay, Claus Peter Schmitt
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Pediatrics
Domonkos Pap, Csenge Pajtok, Apor Veres-szekely, Beata Szebeni, Eszter Levai, Attila J. Szabo, Adam Vannay, Tivadar Tulassay
PEDIATRIC NEPHROLOGY
(2021)
Meeting Abstract
Pediatrics
Beata Szebeni, Zoltan Varga, Istvan Marton Takacs, Domonkos Pap, Apor Veres-szekely, Attila J. Szabo, Gyorgy S. Reusz, Adam Vannay
PEDIATRIC NEPHROLOGY
(2021)