Article
Chemistry, Medicinal
Xiaoli Li, Guoli Wang, Xiaolin Zhou, Huijie Zhao, Xiaojie Chen, Qixiao Cui, Minjing Li, Xihang Gao, Xiaoyu Wei, Lei Ye, Defang Li, Pan Hong
Summary: In this study, it was found that the compound PPP extracted from Dysosma versipellis inhibits the proliferation of gastric cancer cells by blocking the AKT/mTOR signaling pathway and inducing apoptosis. It also suppresses tumor growth in vivo and may target heat shock protein 90 (HSP90) to disrupt its binding to AKT.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Oncology
Jialing Hao, Haitao Mei, Qingshan Luo, Junyong Weng, Jing Lu, Mingmin Liu, Yugang Wen
Summary: TCL1A regulates autophagy through the miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop, exerting a tumor suppressive effect and potentially serving as a therapeutic target for gastric cancer.
Article
Oncology
Chao Wang, Zhi Yang, En Xu, Xiaofei Shen, Xingzhou Wang, Zijian Li, Heng Yu, Kai Chen, Qiongyuan Hu, Xuefeng Xia, Song Liu, Wenxian Guan
Summary: This study found that APOC2 is overexpressed in GC PM tissues and correlates with poor prognosis in GC patients. APOC2 promotes invasion, migration, and proliferation of GC cells through CD36-mediated PI3K/AKT/mTOR signaling pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Junfeng Wang, Zhengwu Cheng, Dafei Dai, Hao Li, Xinyu Shao, Menglin Xu
Summary: Gastric cancer is a leading cause of cancer deaths worldwide. TYRO3 has been identified as a potential therapeutic target for GC as its expression is increased in GC tissues and is associated with poor prognosis, clinicopathological indicators, and the AKT-mTOR pathway. Functional assays showed that TYRO3 plays an oncogenic role by activating the AKT-mTOR pathway, and knocking down TYRO3 can inhibit tumor cell proliferation and migration. This study provides a theoretical basis for the potential association between TYRO3 and AKT-mTOR and offers a new strategy for GC-targeted therapy.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Zheng Chen, Jianguo Zhang, Chenyang Dong, Dongsheng Li, Yuehan Yin, Wenhai Yu, Yuezhi Chen
Summary: The study reveals that TNFAIP8 is significantly up-regulated in gastric cancer tissues and cells, enhancing cell viability, reducing apoptosis, and promoting cell migration. Moreover, TNFAIP8 overexpression promotes autophagy and inhibits the mTOR-Akt-ULK1 signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Food Science & Technology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Soo-Hyun Jung, Bum Seok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: The study demonstrates that oleanolic acid (OA) can inhibit cell viability, induce apoptosis and autophagy, thereby interfering with the proliferation and development of gastric cancer cells, reducing the phosphorylation levels of the PI3K/AKT/mTOR signaling pathway, exhibiting anti-cancer effects, and showing tumor-reducing effects in a mouse model.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Dan Qiao, Jian Xing, Yunxiao Duan, Shiyu Wang, Guangyuan Yao, Shengjun Zhang, Jingchun Jin, Zhenhua Lin, Liyan Chen, Yingshi Piao
Summary: Baicalein inhibits the progression of gastric cancer by regulating the miR-7/FAK/AKT signaling pathway, leading to the suppression of proliferation, metastasis, and angiogenesis in gastric cancer cells.
Article
Chemistry, Medicinal
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh
Summary: Carnosic acid inhibits proliferation and survival of human gastric cancer cells in a dose-dependent manner by suppressing the phosphorylation/activation of Akt and mTOR, and enhancing cleavage of PARP as well as downregulating survivin expression.
Article
Oncology
Huange Zhao, Xian Zhang, Min Wang, Yingying Lin, Songlin Zhou
Summary: Stigmasterol (SS) induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the Akt/mTOR pathway, showing potential as an anticancer drug. Pretreatment with an Akt inhibitor enhances apoptosis and autophagy induced by SS, while autophagy mediated by SS plays a cytoprotective role against apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guang Chen, Huhu Zhang, Hongxiao Sun, Xiaoyan Ding, Guoxiang Liu, Fanghao Yang, Guilin Feng, Xiaolei Dong, Yunfan Zhu, Xiaotong Wang, Yafei Wang, Bing Li, Lina Yang
Summary: Gastric cancer (GC) is a common malignant tumor and bufalin has been proven to play an anticancer role in various cancers. However, the studies on bufalin in GC are limited. This study aimed to investigate the effect of bufalin on GC cells and identify its direct interaction protein and target. The results showed that bufalin inhibited the proliferation and migration of GC cells in vitro. BFAR was identified as a direct interaction protein of bufalin that promotes the occurrence and metastasis of GC through the PI3K/AKT/mTOR signaling pathway. Bufalin reversed the promoting effect of BFAR on GC and inhibited its development. These findings suggest that bufalin targeting BFAR could be a promising drug for the treatment of GC.
Review
Pharmacology & Pharmacy
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash
Summary: Genetic and epigenetic alterations have long been the focus of cancer pathogenesis research, with dysregulated genes and protein products potentially affecting cancer cell growth through signaling cascades regulating cell survival and metabolism. The activation of the phosphatidylinositol-3-kinase (PI3K) axis in about one-third of human cancers, including gastric cancer, plays a significant role in the development of malignancies. This indicates the potential importance of targeting this axis in therapeutic strategies for such cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yunhao Ma, Hao Xu, Zhongkun Zhou, Yanan Tian, Kangjia Du, Hao Zhang, Xinrong Jiang, Juan Lu, Yuqing Niu, Lixue Tu, Huanxiang Liu, Hongmei Zhu, Peng Chen, Yingqian Liu
Summary: In the treatment of gastric cancer, natural products modified by structural modification can be a promising strategy for finding anti-gastric cancer drugs. In this study, a novel derivative CFNC was synthesized and found to have potential anti-gastric cancer effects by regulating the PI3K/AKT/mTOR signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pankaj Gupta, Usha Dutta, Pratyaksha Rana, Manphool Singhal, Ajay Gulati, Naveen Kalra, Raghuraman Soundararajan, Daneshwari Kalage, Manika Chhabra, Vishal Sharma, Vikas Gupta, Thakur Deen Yadav, Lileshwar Kaman, Santosh Irrinki, Harjeet Singh, Yashwant Sakaray, Chandan Krishuna Das, Uma Saikia, Ritambhara Nada, Radhika Srinivasan, Manavjit Singh Sandhu, Raju Sharma, Nitin Shetty, Anu Eapen, Harmeet Kaur, Avinash Kambadakone, Robbert de Haas, Vinay K. Kapoor, Savio George Barreto, Atul K. Sharma, Amol Patel, Pramod Garg, Sujoy K. Pal, Mahesh Goel, Shraddha Patkar, Anu Behari, Anil K. Agarwal, Bhawna Sirohi, Milind Javle, Giuseppe Garcea, Flavio Nervi, Volkan Adsay, Juan Carlos Roa, Ho-Seong Han
Summary: The GB-RADS ultrasound risk stratification system categorizes gallbladder wall thickening into six categories based on features such as symmetry, layered appearance, intramural features, and interface with the liver. This collaborative effort aims to improve the accuracy of detecting malignant lesions and enhance management strategies for gallbladder conditions.
ABDOMINAL RADIOLOGY
(2022)
Review
Oncology
Ismael Riquelme, Pablo Perez-Moreno, Pablo Letelier, Priscilla Brebi, Juan Carlos Roa
Summary: This article reviews the important aspects of piRNAs, including their molecular characteristics, biosynthesis processes, gene expression silencing mechanisms, and their study in GI cancer samples and cell lines. It also discusses the potential clinical utility of piRNAs as biomarkers and therapeutic targets in gastrointestinal cancers.
Article
Health Care Sciences & Services
Pablo Perez-Moreno, Ismael Riquelme, Patricia Garcia, Priscilla Brebi, Juan Carlos Roa
Summary: Gallbladder cancer is an aggressive neoplasm that is often asymptomatic in early stages and is typically diagnosed at an advanced stage. The presence of gallstones is the main risk factor, while other factors such as inflammation can also contribute to the development of gallbladder cancer. Understanding the early carcinogenic mechanisms is crucial for prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Alejandra M. Sandoval-Borquez, Ignacio Wichman, Gonzalo Carrasco-Avino, Alejandro Corvalan, Sergio Lavandero, Andrew F. G. Quest
Review
Biochemistry & Molecular Biology
Ismael Riquelme, Pablo Perez-Moreno, Barbara Mora-Lagos, Carmen Ili, Priscilla Brebi, Juan Carlos Roa
Summary: Gastric cancer is a significant cause of cancer-related deaths, particularly among younger people. Late diagnosis, metastasis, and drug resistance contribute to the high mortality rate of gastric cancer. There is a need for new biomarkers and therapeutic targets. RNA-seq technology has identified long non-coding RNAs (lncRNAs) as potential regulators of cancer cells' signaling pathways, including the PI3K/AKT/mTOR pathway, and they may serve as diagnostic or prognostic biomarkers or therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luis Vergara-Gomez, Carolina Bizama, Jun Zhong, Kurt Buchegger, Felipe Suarez, Lorena Rosa, Carmen Ili, Helga Weber, Javiera Obreque, Karena Espinoza, Gabriela Repetto, Juan C. Roa, Pamela Leal, Patricia Garcia
Summary: This study investigated the molecular mechanisms of acquired resistance in gallbladder cancer by developing and characterizing gemcitabine-resistant cell lines. Transcriptome profiling and phosphotyrosine proteomic analyses revealed dysregulated biological processes and signaling pathways, as well as potential therapeutic targets in gallbladder cancer. The findings greatly enhance our understanding of acquired drug resistance in gallbladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Elena Reyes, Louise Zanella, Ismael Riquelme, Kurt Buchegger, Barbara Mora-Lagos, Pablo Guzman, Patricia Garcia, Juan C. Roa, Carmen Gloria Ili, Priscilla Brebi
Summary: This study aimed to investigate the frequency and genetic diversity of EBV in gastric cancer (GC) patients in southern Chile. The study found that 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology. The results provide important information for epidemiological follow-up of different EBV subtypes that may cause GC in southern Chile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bahar Memis, Burcu Saka, Juan Carlos Roa, Sudeshna Bandyopadhyay, Michelle Reid, Pelin Bagci, Berk Kaan Aktas, Ayse Armutlu, Olca Basturk, N. Volkan Adsay
Summary: Eosinophilic cholecystitis is a rare condition characterized by thickening of the gallbladder wall and infiltration of eosinophils, which is most commonly seen in patients with subacute and acute cholecystitis.
Review
Biochemistry & Molecular Biology
Jose Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martinez, Angelo Torres, Rody San Martin, Juan Carlos Roa, Claudia Quezada-Monras
Summary: Glioblastoma (GBM) is a common and malignant brain cancer with poor prognosis. Its low effectiveness is attributed to tumor infiltration into healthy brain tissue, which depends on the interaction between GBM cells and the tumor microenvironment (TME). This review highlights the use of 3D patient-derived glioblastoma organoid cultures as a new platform for studying TME and invasiveness. It discusses the mechanisms involved in GBM-TME interaction and proposes potential prognostic biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Maria Tosta Perez, Lisandra Herrera Belen, Pablo Letelier, Yolanda Calle, Adalberto Pessoa, Jorge G. Farias
Summary: L-Asparaginase is an approved antileukemic drug for childhood acute lymphoblastic leukemia, but its efficacy and use have been debated due to adverse effects, rapid plasma elimination, multiple administrations, and allergic reactions. Finding less immunogenic variants has been a focus of study. This review presents the aspects of L-asparaginase enzyme from structural, pharmacological, and clinical perspectives in chemotherapy protocols with other drugs.