Article
Biochemistry & Molecular Biology
Johannes Wolf, Edith Willscher, Henry Loeffler-Wirth, Maria Schmidt, Gunter Flemming, Marlen Zurek, Holm H. Uhlig, Norman Handel, Hans Binder
Summary: This study provides a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of children and adolescents with active CD, revealing three distinct CD patient groups. The persistence of symptoms was weakly associated with subgroups, with the CD-high group showing the highest marsh stages and cell cycle rates, indicating virtually complete villous atrophy. Inflammation-level differences between subgroups were further deciphered into immune cell types using cell type de-convolution. The application of self-organizing maps provided high-resolution landscapes of the CD-transcriptome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiaoye Qu, Yankai Wen, Junzhe Jiao, Jie Zhao, Xuehua Sun, Fang Wang, Yueqiu Gao, Weifeng Tan, Qiang Xia, Hailong Wu, Xiaoni Kong
Summary: Park7/Dj1 is a regulator of PTEN-dependent fatty acid beta-oxidation, and increasing its expression could be a promising strategy for promoting liver regeneration.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni Casella, Carlo Catassi, Carolina Ciacci, Delia Gabriela Apostol Ciobanu, Simon S. Cross, Mihai Danciu, Prasenjit Das, Rachele Del Sordo, Michael Drage, Luca Elli, Alessio Fasano, Ada Maria Florena, Nicola Fusco, James J. Going, Stefano Guandalini, Catherine E. Hagen, David T. S. Hayman, Sauid Ishaq, Hilary Jericho, Melanie Johncilla, Matt Johnson, Katri Kaukinen, Adam Levene, Sarah Liptrot, Laura Lu, Govind K. Makharia, Sherly Mathews, Giuseppe Mazzarella, Roxana Maxim, Khun La Win Myint, Hamid Mohaghegh-Shalmani, Afshin Moradi, Chris J. J. Mulder, Ronnie Ray, Chiara Ricci, Mohammad Rostami-Nejad, Anna Sapone, David S. Sanders, Juha Taavela, Umberto Volta, Marjorie Walker, Mohammad Derakhshan
Summary: The histological changes in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) show distinct alterations consistent with an intestinal response to luminal antigens, even at the Marsh 0 stage of villus architecture.
Article
Gastroenterology & Hepatology
Michal Kori, Yonatan Zamir, Sami Or Yermiyahu, Inessa Ainbinder, Svetlana Daichman, Gavriel David Pinto, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Natan Lederman, Eran Matz, Raanan Shamir, Iris Dotan, Dan Turner
Summary: This study found that the prevalence of coeliac disease (CeD) and coeliac autoimmunity (CeA) is higher in patients with inflammatory bowel diseases (IBD), especially in paediatric-onset IBD and Crohn's disease (CD). The diagnosis of CeD usually precedes the diagnosis of IBD, and patients with both IBD and CeD receive more intensified treatment for IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Sara Bacchi, Federico Biagi, Simona Panelli, Elena Betti, Gino Roberto Corazza, Enrica Capelli, Rachele Ciccocioppo
Summary: Untreated coeliac disease patients with iron deficiency anemia demonstrated a pro-inflammatory shift in their duodenal microbiota, while coeliac patients on a strict GFD with persistent diarrhea exhibited differences in duodenal microbiota composition compared to those with other types of persistent symptoms.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Nutrition & Dietetics
Anna Szaflarska-Poplawska, Aleksandra Dolinska, Magdalena Kusmierek
Summary: The aim of this study was to evaluate nutritional imbalances in children with coeliac disease (CD) on a strict gluten-free diet (GFD). The results showed that children with CD had lower levels of folic acid and vitamin B-1, lower calcium levels, and lower intake of calcium, folic acid, and vitamin D compared to dietary recommendations. However, their intake of proteins and carbohydrates exceeded the recommended levels. Additionally, a significantly higher number of CD children were classified as underweight.
Article
Endocrinology & Metabolism
Clemens Kamrath, Sascha R. Tittel, Desiree Dunstheimer, Elke Froehlich-Reiterer, Markus Freff, Claudia Boettcher, Nadine Scheffler, Stefanie Lenze, Elke Gericke, Susanne Thiele, Reinhard W. Holl
Summary: The study aims to analyze whether the confirmation of coeliac disease can be postponed in children with new-onset type 1 diabetes and positive screening results.
Article
Medicine, General & Internal
Thomas Inns, Kate M. Fleming, Miren Iturriza-Gomara, Daniel Hungerford
Summary: A cohort study in the UK found that rotavirus vaccination was not associated with the prevention of coeliac disease (CD) or type 1 diabetes (T1D) in children.
Article
Nutrition & Dietetics
Marco Crocco, Angela Calvi, Paolo Gandullia, Federica Malerba, Anthea Mariani, Sonia Di Profio, Barbara Tappino, Stefano Bonassi
Summary: This study aimed to assess the Health-Related Quality of Life (HRQoL) of Italian children and their parents with coeliac disease using the Coeliac Disease Dutch Questionnaire (CDDUX). The Italian version of the CDDUX questionnaire was found to be a valid and reliable tool for evaluating HRQoL in children and adolescents with CD, showing significant differences in HRQoL among populations of different nationalities. The main clinical variable affecting HRQoL in both children and parents was found to be lower age.
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, David S. Sanders, Paola Baiardi, Giacomo Caio, Carolina Ciacci, Katri Kaukinen, Benjamin Lebwohl, Daniel Leffler, Georgia Malamut, Joseph A. Murray, Kamran Rostami, Alberto Rubio-Tapia, Umberto Volta, Federico Biagi
Summary: This study achieved a consensus on the definitions and diagnostic criteria for seronegative coeliac disease and chronic non-coeliac enteropathies in adults through the Delphi process.
Article
Medicine, General & Internal
Giulia Pivetta, Chiara Coluccio, Emanuele Dilaghi, Edith Lahner, Emanuela Pilozzi, Marilia Carabotti, Vito Domenico Corleto
Summary: Iron-deficiency anemia in the elderly may be caused by various gastrointestinal conditions. The use of routine duodenal biopsies for diagnostic purposes in elderly patients is debated. A cross-sectional study analyzing 7968 gastroscopies was conducted to determine the diagnostic value of routine duodenal biopsies in adult and elderly patients with no bleeding anemia. The study found limited diagnostic yield of routine duodenal biopsies in this population.
Article
Biochemistry & Molecular Biology
Sebastian Stricker, Jan de Laffolie, Klaus-Peter Zimmer, Silvia Rudloff
Summary: This study found that PX-12 is an effective inhibitor of TG2, reducing the cross-linking reaction of PTG in cells. ERW1041 showed weaker inhibitory effect compared to PX-12. In addition, ERW1041 also inhibited the absorption of P56-88 by Caco-2 cells. In conclusion, TG2 inhibitors have potential therapeutic effects in the treatment of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong
Summary: PARK7 plays a protective role in septic AKI by suppressing NF-KB signaling, thereby alleviating kidney tissue damage and dysfunction.
Article
Chemistry, Medicinal
Kenneth Schmidt, Janelle Noel-MacDonnell, Carrie Vyhlidal, Daniel P. Heruth, Vivekanand Singh, Atif A. Ahmed, Taina Hudson, Veronica Williams, Valentina Shakhnovich
Summary: This study aimed to characterize the bacterial composition of the mucosally-adherent duodenal microbiome in children with and without CD. Significant differences were found between the control and CD groups in terms of bacterial abundance, composition, and diversity, providing a foundation for the development of targeted IBD treatment strategies.
Article
Gastroenterology & Hepatology
Fabiana Zingone, Ilaria Marsilio, Matteo Fassan, Valentina Pilotto, Gemma Maddalo, Greta Lorenzon, Edoardo Vincenzo Savarino, Fabio Farinati
Summary: Autoimmune atrophic gastritis (AAG) is characterized by a range of symptoms and has been associated with other autoimmune diseases. This study aimed to evaluate duodenal histological findings and the risk of CeD in AAG patients, finding that the presence of other autoimmune diseases did not influence the risk of CeD.
Article
Gastroenterology & Hepatology
Nora J. Beres, Doloresz Szabo, Dorottya Kocsis, Daniel Szucs, Zoltan Kiss, Katalin E. Mueller, Gabor Lendvai, Andras Kiss, Andras Arato, Erna Sziksz, Adam Vannay, Attila J. Szabo, Gabor Veres
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Gastroenterology & Hepatology
Katalin E. Mueller, Peter L. Lakatos, Judit B. Kovacs, Andras Arato, Agnes Varkonyi, Eva Nemes, Andras Tarnok, Gergely Toth, Maria Papp, Eniko Solyom, Agnes Horvath, Ildiko Guthy, Marta Kovacs, Gabor Veres
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2016)
Article
Biochemistry & Molecular Biology
Jozsef Muranyi, Pal Gyulavari, Attila Varga, Gyorgyi Bokonyi, Henriette Tanai, Tibor Vantus, Domonkos Pap, Krisztina Ludanyi, Gabor Mezo, Gyorgy Keri
JOURNAL OF PEPTIDE SCIENCE
(2016)
Article
Pediatrics
Rozsa Csohany, Agnes Prokai, Erna Sziksz, Leonora Balicza-Himer, Domonkos Pap, Anna Kosik, Daniel Sugar, Adam Vannay, Katalin Kis-Petik, Andrea Fekete, Attila J. Szabo
PEDIATRIC TRANSPLANTATION
(2016)
Article
Immunology
Agnes Prokai, Rozsa Csohany, Erna Sziksz, Domonkos Pap, Leonoa Balicza-Himer, Szilvia Boros, Balazs Magda, Adam Vannay, Katalin Kis-Petik, Andrea Fekete, Janos Peti-Peterdi, Attila J. Szabo
Article
Immunology
Csaba Orban, Doloresz Szabo, Anna Bajnok, Barna Vasarhelyi, Tivadar Tulassay, Andras Arato, Gabor Veres, Gergely Toldi
IMMUNOLOGY LETTERS
(2017)
Article
Biochemistry & Molecular Biology
Zoltan Kiss, Nora Judit Beres, Erna Sziksz, Balint Tel, Katalin Borka, Andras Arato, Attila J. Szabo, Gabor Veres
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Physiology
Domonkos Pap, Erna Sziksz, Zoltan Kiss, Reka Rokonay, Apor Veres-Szekely, Rita Lippai, Istvan Marton Takacs, Eva Kis, Andrea Fekete, Gyorgy Reusz, Attila J. Szabo, Adam Vannay
KIDNEY & BLOOD PRESSURE RESEARCH
(2017)
Article
Medicine, Research & Experimental
Domonkos Pap, Apor Veres-Szekely, Beata Szebeni, Reka Rokonay, Anna Onody, Rita Lippai, Istvan Marton Takacs, Andras Tisler, Magdolna Kardos, Franz Oswald, Andrea Fekete, Attila J. Szabo, Adam Vannay
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell Biology
Apor Veres-Szekely, Maria Bernath, Domonkos Pap, Reka Rokonay, Beata Szebeni, Istvan M. Takacs, Rita Lippai, Aron Cseh, Attila J. Szabo, Adam Vannay
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Physiology
Robert Agocs, Domonkos Pap, Daniel Sugar, Gabor Toth, Lilla Turiak, Zoltan Vereb, Lajos Kemeny, Tivadar Tulassay, Adam Vannay, Attila J. Szabo
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Anna Onody, Apor Veres-Szekely, Domonkos Pap, Reka Rokonay, Beata Szebeni, Erna Sziksz, Franz Oswald, Gabor Veres, Aron Cseh, Attila J. Szabo, Adam Vannay
Summary: The study demonstrates increased IL-24 expression in serum and colon samples of children with IBD and DSS treated mice. Inflammatory factors such as IL-1 beta, LPS, and H2O2 can increase IL24 expression in PBMCs and LPMCs. IL-24 treatment promotes the expression of TGF-beta and PDGF-B in HT-29 cells, as well as enhances ECM-related gene expression and motility in CCD-18Co cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Domonkos Pap, Csenge Pajtok, Apor Veres-Szekely, Beata Szebeni, Csenge Szasz, Peter Bokrossy, Reka Zrufko, Adam Vannay, Tivadar Tulassay, Attila J. Szabo
Summary: Recent studies have shown that excessive salt intake can induce fibrotic changes in the peritoneum. This study aimed to better understand the underlying mechanisms. The results demonstrated that high-salt environments and increased osmolarity can lead to the production of inflammatory cytokines, profibrotic growth factors, and components of the renin-angiotensin-aldosterone system. Additionally, high salt was found to induce mesenchymal transition and increase extracellular matrix production. These findings contribute to our understanding of peritoneal fibrosis development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Apor Veres-Szekely, Domonkos Pap, Erna Sziksz, Eszter Javorszky, Reka Rokonay, Rita Lippai, Kalman Tory, Andrea Fekete, Tivadar Tulassay, Attila J. Szabo, Adam Vannay
BMC MOLECULAR BIOLOGY
(2017)
Article
Gastroenterology & Hepatology
Nra Judit Beres, Zoltan Kiss, Zsofia Sztupinszki, Gabor Lendvai, Andras Arato, Erna Sziksz, Adam Vannay, Attila J. Szabo, Katalin Eszter Muller, Aron Cseh, Kriszta Boros, Gabor Veres
DIGESTIVE AND LIVER DISEASE
(2017)