Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Meike Kohlruss, Marie Krenauer, Bianca Grosser, Nicole Pfarr, Moritz Jesinghaus, Julia Slotta-Huspenina, Alexander Novotny, Alexander Hapfelmeier, Thomas Schmidt, Katja Steiger, Matthias M. Gaida, Magdalena Reiche, Lukas Bauer, Katja Ott, Wilko Weichert, Gisela Keller
Summary: The study investigated the predictive and prognostic value of different molecular subtypes in gastric carcinomas, with a focus on chromosomal instability (CIN) in the context of neoadjuvant chemotherapy (CTx). It was found that EBV(+), MSI-H, and GS were associated with increased survival compared to CIN in resected tumors, while CIN-substantial was a negative prognostic factor in tumors with CTx. CIN-high predicted tumor regression in biopsies before CTx but was not prognostically relevant.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Sangjoon Choi, Hyunjin Kim, You Jeoung Heo, So Young Kang, Soomin Ahn, Jeeyun Lee, Kyoung-Mee Kim
Summary: PIK3CA mutations in gastric cancer affect tumor immunogenicity and may influence therapeutic responses. Different PIK3CA mutation subtypes are associated with distinct immune profiles and expression levels of immune-related proteins in gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Hung-Yuan Yu, Chung-Pin Li, Yi-Hsiang Huang, Shao-Jung Hsu, Yen-Po Wang, Yun-Cheng Hsieh, Wen-Liang Fang, Kuo-Hung Huang, Anna Fen-Yau Li, Rheun-Chuan Lee, Kang-Lung Lee, Yuan-Hung Wu, I-Chun Lai, Wan-Chin Yang, Yi-Ping Hung, Yu-Chao Wang, Shu-Hui Chen, Ming-Huang Chen, Yee Chao
Summary: Immunotherapy has shown benefits in selected cases of gastric cancer, with MSI-H and CPS >= 5 being useful biomarkers associated with better clinical responses and progression-free survival. EBER was only associated with improved outcomes in patients with CPS >= 1.
Article
Oncology
Hedde D. Biesma, Tanya T. D. Soeratram, Karolina Sikorska, Irene A. Caspers, Hendrik F. van Essen, Jacqueline M. P. Egthuijsen, Aart Mookhoek, Hanneke W. M. van Laarhoven, Mark I. van Berge Henegouwen, Marianne Nordsmark, Donald L. van der Peet, Fabienne A. R. M. Warmerdam, Maud M. Geenen, Olaf J. L. Loosveld, Johanneke E. A. Portielje, Maartje Los, Danielle A. M. Heideman, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Johanna van Sandick, Marcel Verheij, Cornelis J. H. van de Velde, Annemieke Cats, Bauke Ylstra, Nicole C. T. van Grieken
Summary: This study found that EBV positivity and high microsatellite instability (MSI) were positive prognostic factors in resectable gastric cancer. However, the benefits of perioperative treatment for MSI-high tumors remain uncertain. Interestingly, MSI-high tumors with substantial histopathological response were predominantly of the mucinous phenotype. These findings suggest that mucinous phenotype could be an important parameter in future clinical trials for MSI-high patients.
Article
Oncology
Catarina Neto do Nascimento, Luis Mascarenhas-Lemos, Joao Ricardo Silva, Diogo Sousa Marques, Catarina Ferreira Gouveia, Ana Faria, Sonia Velho, Rita Garrido, Rui Maio, Andreia Costa, Patricia Pontes, Xiaogang Wen, Irene Gullo, Marilia Cravo, Fatima Carneiro
Summary: Gastric cancer is characterized by high morphologic and molecular heterogeneity. The impact of microsatellite instability (MSI) and Epstein-Barr virus (EBV) status in gastric cancer (GC) regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS) was investigated. Although MSI and EBV status did not influence OS or PFS, females with MSI-high tumors treated with POPChT demonstrated superior survival compared to females with MSS tumors, suggesting that sex disparities and molecular classification may influence treatment options in GC.
Article
Multidisciplinary Sciences
Na Yang, Yanhua Wu, Meishan Jin, Zhifang Jia, Yueqi Wang, Donghui Cao, Lili Qin, Xueying Wang, Min Zheng, Xueyuan Cao, Jing Jiang
Summary: The study demonstrates that the combination of molecular subtypes with PD-L1 expression in gastric cancer patients can better predict prognosis and guide postoperative chemotherapy. Patients in the MSS/EBV- subgroup may benefit from postoperative chemotherapy, and PD-L1-positive expression could predict a better prognosis.
Review
Cell Biology
Arghavan Zebardast, Sadra S. Tehrani, Tayebeh Latifi, Farzin Sadeghi
Summary: EBV-encoded miRNAs play a crucial role in the pathogenesis of EBVaGC, participating in carcinogenesis and the progression of malignancies by regulating gene expression and other activities.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Ahmad Firoz, Hani Mohammed Ali, Suriya Rehman, Irfan A. Rather
Summary: Gastric cancer is a global health concern with a significant number of cases. Early diagnosis and treatment improve survival rates, but advanced stage tumors have lower survival rates. Oncolytic viruses show promise as more efficient diagnostic and treatment strategies. Oncogenic viruses play a significant role in gastric cancer progression.
Review
Gastroenterology & Hepatology
Hisashi Iizasa, Andy Visi Kartika, Sintayehu Fekadu, Shunpei Okada, Daichi Onomura, Afifah Fatimah Azzahra Ahmad Wadi, Mosammat Mahmuda Khatun, Thin Myat Moe, Jun Nishikawa, Hironori Yoshiyama
Summary: This article discusses the roles of Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) infections in the formation of gastric cancer. Previous studies have suggested that H. pylori infection may cooperate with EBV infection to promote gastric cancer development, while others have reported that H. pylori infection accelerates tumorigenesis caused by EBV infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Xueyi Zheng, Ruixuan Wang, Xinke Zhang, Yan Sun, Haohuan Zhang, Zihan Zhao, Yuanhang Zheng, Jing Luo, Jiangyu Zhang, Hongmei Wu, Dan Huang, Wenbiao Zhu, Jianning Chen, Qinghua Cao, Hong Zeng, Rongzhen Luo, Peng Li, Lilong Lan, Jingping Yun, Dan Xie, Wei-Shi Zheng, Junhang Luo, Muyan Cai
Summary: This study introduces a deep convolutional neural network called EBVNet and its fusion with pathologists for predicting Epstein-Barr virus-associated gastric cancer (EBVaGC) from histopathology. EBVNet shows high accuracy in discriminating EBVaGC and the human-machine fusion significantly improves diagnostic performance.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Emilie Bessede, Francis Megraud
Summary: The discovery of Helicobacter pylori in 1982 led to a shift in understanding the stomach as a sterile organ. Further research revealed that the stomach contains a diverse microbiota, with H. pylori being the essential species that influences the richness and evenness of other bacterial communities. H. pylori is now recognized as the main risk factor for gastric cancer, particularly the strains carrying the cag pathogenicity island and the CagA oncoprotein. However, there is a need to consider other factors from the host and environment in explaining the differences between those infected with H. pylori and those developing gastric cancer. Studies have shown differences in the gastric microbiota at various stages of gastric premalignant and malignant lesions, indicating reduced microbial diversity and an increase in intestinal commensals with nitrosative functions. The role of other microorganisms, such as the Epstein-Barr virus and mycobiota, also needs further exploration. Animal models have provided insights into the role of different gastric microbiota apart from H. pylori.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, General & Internal
Michele Ghidini, Angelica Petrillo, Andrea Botticelli, Dario Trapani, Alessandro Parisi, Anna La Salvia, Elham Sajjadi, Roberto Piciotti, Nicola Fusco, Shelize Khakoo
Summary: Despite challenges in treating gastric cancer, immunotherapy may offer new hope. While predictive biomarkers exist, clinical implementation remains difficult.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Correction
Oncology
Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keranen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O'Mara, Annabelle Lewis
Summary: The paper has been amended and the revised version can be accessed through the original article.
CLINICAL EPIGENETICS
(2021)