Article
Immunology
A. Elisabeth Gressler, Sabrina Luebke, Bettina Wagner, Corinna Arnold, Katharina L. Lohmann, Christiane L. Schnabel
Summary: Equine asthma, a common disease affecting approximately 20% of horses, shows similarities to human asthma and is believed to be immune-mediated. By analyzing the cell populations in the lower airways of horses with different severities of equine asthma, researchers identified characteristic changes in the cell compositions, highlighting potential differences between severe cases and mild to moderate cases as well as healthy horses. These findings contribute to a better understanding of the pathogenesis of equine asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Srinivas Akula, Miia Riihimaki, Ida Waern, Magnus Abrink, Amanda Raine, Lars Hellman, Sara Wernersson
Summary: This study provides the first insight into the phenotype of equine MCs in bronchoalveolar lavage fluid (BALF) and their potential role in the airways of asthmatic horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Andrey Mamontov, Igor Losev, Dmitrii Korzhevskii, Valeriia Guselnikova, Alexander Polevshchikov, Yulia Desheva
Summary: In this study, it was found that murine MCs can be activated to release histamine by introducing immune complexes, with a more significant effect on A/H5N1 influenza virus. The use of histamine receptor blockers can increase the survival rate of immunized mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fahad Raza, Susanna Babasyan, Elisabeth M. Larson, Heather S. Freer, Christiane L. Schnabel, Bettina Wagner
Summary: IL-4 plays a crucial role in orchestrating immune responses during allergic reactions, with basophils potentially providing initial IL-4 to drive T cell development towards the Th2 phenotype. In horses with Culicoides hypersensitivity (CH), peripheral blood basophils produce high amounts of IL-4 after stimulation with Cul allergens, indicating a potential underestimated role of basophils in CH. Further research is needed to clarify the mechanism of IL-4 production by basophils and its impact on immune responses in horses with CH.
Review
Biochemistry & Molecular Biology
Antonio Giovanni Solimando, Vanessa Desantis, Domenico Ribatti
Summary: Mast cells are crucial for inflammatory diseases and tumor growth, as they can secrete a wide range of biologically active cytokines. This review article aims to analyze the complex involvement of mast cells in interleukin secretion and the role of interleukins in regulating mast cell activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Barry A. A. Hedgespeth, Douglas B. Snider, Katie J. Bitting, Glenn Cruse
Summary: This article introduces a oligonucleotide called KitStop, which can safely reduce the severity and duration of anaphylactic response by reducing the number of mast cells in tissues. The study shows that KitStop significantly reduces mast cell numbers in the skin and peritoneum, and mice treated with KitStop experience a significantly diminished anaphylactic response in a model of passive systemic anaphylaxis compared to control mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mariela Jimenez, Daniel Cervantes-Garcia, Laura E. Cordova-Davalos, Marian Jesabel Perez-Rodriguez, Claudia Gonzalez-Espinosa, Eva Salinas
Summary: Mast cells are immune cells strategically located in tissues close to the external environment, playing a key role in the host defense against invading pathogens. They release biologically active mediators to induce inflammation, promote antimicrobial activities, and shape innate and adaptive immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katerina Kalkusova, Sindija Smite, Elea Darras, Pavla Taborska, Dmitry Stakheev, Luca Vannucci, Jirina Bartunkova, Daniel Smrz
Summary: The immune checkpoint inhibitors are crucial in cancer immunotherapy, but their efficacy is limited in solid tumors. Mast cells and dendritic cells play important roles in the tumor immune microenvironment and controlling these cells may help overcome the resistance of solid tumors to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Pingwei Zhao, Peiwen Zhou, Tongyu Tang, Rui Si, Yiding Ji, Xintong Hu, Ang Li, Yanfang Jiang
Summary: The study found that circulating MCps levels were lower in patients with CRC, but significantly increased after surgery; however, the frequency of mast cells in tumor tissues was lower and not associated with CRC progression.
Article
Biochemistry & Molecular Biology
Marco Maccarana, Juan Jia, Honglian Li, Xiao Zhang, Israel Vlodavsky, Jin-Ping Li
Summary: Heparin, a polysaccharide expressed in animal connective tissue, specifically binds to antithrombin and enhances its inhibitory activity. This study examined the heparin isolated from different mast cells and found differences in molecular size and antithrombin-binding activity. Heparanase expression affected the production of glycosaminoglycans and the proportion between heparin and other glycosaminoglycans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Proano-Perez, Laia Olle, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Munoz-Cano, Margarita Martin
Summary: Activating mutations in KIT (CD117) are associated with various diseases, and recent research found that the SH3BP2 pathway regulates MITF through miR-1246 and miR-5100, suggesting that MITF may be a potential therapeutic target for gastrointestinal stromal tumors and mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dmitri Atiakshin, Andrey Kostin, Igor Buchwalow, Vera Samoilova, Markus Tiemann
Summary: This study investigates the expression and secretory pathways of proteases in MCs in melanoma. The development of melanoma leads to the appearance of specific protease pools in the tumor-associated MC population, which is crucial for understanding the pathogenesis, classification, and prognosis of melanoma, as well as evaluating the effectiveness of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sina Kaag, Axel Lorentz, Katarina Stevanovic, Torsten Zuberbier
Summary: This review summarizes the anti-inflammatory effects of dietary components on mast cells and the signaling pathways involved, providing potential nutraceuticals for the prevention and treatment of allergies.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Giulia Piccini, Noemi Manganaro, Piero Pileri, Inesa Hyseni, Margherita Leonardi, Elisa Pantano, Valentina Abbiento, Linda Benincasa, Ginevra Giglioli, Concetta De Santi, Massimiliano Fabbiani, Ilaria Rancan, Mario Tumbarello, Francesca Montagnani, Claudia Sala, Emanuele Montomoli, Rino Rappuoli
Summary: Research suggests that individuals who have been infected or vaccinated for the first time will produce antibodies with increased potency and breadth, allowing for better control of emerging SARS-CoV-2 variants.