期刊
ELIFE
卷 4, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.04605
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资金
- European Commission EU FP7 VERE
- European Commission Flagship HBP
- Israel Science Foundation ICORE
- Wellcome Trust
- National Institute for Health Research Oxford Biomedical Research Centre
- European Commission EU FP7 ABC grant [PITN-GA-2008-290011]
- Royal Society Newton International Fellowship
- European Commission (Marie Curie Intra- European Fellowship
- Wellcome Trust Sir Henry Dale Fellowship
- Royal Society Sir Henry Dale Fellowship
- Israeli Presidential Bursary
- Boehringer Ingelheim
- Engineering and Physical Sciences Research Council [EP/L023067/1] Funding Source: researchfish
- Wellcome Trust [104128/A/14/Z] Funding Source: researchfish
- EPSRC [EP/L023067/1] Funding Source: UKRI
Previously we showed, using task-evoked fMRI, that compensatory intact hand usage after amputation facilitates remapping of limb representations in the cortical territory of the missing hand (Makin et al., 2013a). Here we show that compensatory arm usage in individuals born without a hand (one-handers) reflects functional connectivity of spontaneous brain activity in the cortical hand region. Compared with two-handed controls, one-handers showed reduced symmetry of hand region inter-hemispheric resting-state functional connectivity and corticospinal white matter microstructure. Nevertheless, those one-handers who more frequently use their residual (handless) arm for typically bimanual daily tasks also showed more symmetrical functional connectivity of the hand region, demonstrating that adaptive behaviour drives long-range brain organisation. We therefore suggest that compensatory arm usage maintains symmetrical sensorimotor functional connectivity in one-handers. Since variability in spontaneous functional connectivity in our study reflects ecological behaviour, we propose that inter-hemispheric symmetry, typically observed in resting sensorimotor networks, depends on coordinated motor behaviour in daily life.
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