期刊
ELIFE
卷 4, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.07661
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资金
- National Health and Medical Research Council (NHMRC) [1022509, 1085017]
- National Institutes of Health (NIH) [HHSN272201200010C, HHSN272200900044C]
- European Research Council (ERC) [ERC-2008-AdG_20080422]
- Schweizerische Nationalfonds zur Forderung der Wissenschaftlichen Forschung [3100A0-688 107679]
- European Commission (EC) [241587]
- German Cancer Consortium (DKTK)
- Bundesministerium fur Bildung und Forschung [0316179C]
- Forschungszentrum Immuntherapie (FZI) of the Johannes Gutenberg University Mainz
- Ministerio de Economia y Competitividad Carlos III Health Institute (ISCIII) (ProteoRed-PRB2) [PT13/0001]
- European Commission (EC)
- Schweizerische Nationalfonds zur Forderung der Wissenschaftlichen Forschung
- National Institute of General Medical Sciences (NIGMS) [R01GM087221, 2P50GM076547]
- National Health and Medical Research Council of Australia [1085017] Funding Source: NHMRC
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
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