Article
Pathology
Eileen Larsen, Allison M. Watson, Juan F. Munoz Gutierrez
Summary: This retrospective study focused on primary intranasal mast cell tumors (MCTs) in dogs. The study found that intranasal MCTs tend to metastasize and have a generally poor prognosis, resembling the behavior of MCTs in other mucosal locations. Dogs with metastatic disease and survival times of <1 year often exhibit specific clinical features.
VETERINARY PATHOLOGY
(2022)
Article
Veterinary Sciences
Polly Chen, Laura Marconato, Silvia Sabattini, Matti Kiupel
Summary: This study found a higher prevalence of c-kit mutations in exons 8 and 11 in subcutaneous MCTs in dogs, and exon 11 mutations were associated with histologic high grade and a high mitotic count.
VETERINARY SCIENCES
(2022)
Article
Parasitology
Ilaria Porcellato, Giulia Morganti, Maria Teresa Antognoni, Katarzyna Malgorzata Walczak, Stefano De Arcangeli, Tommaso Furlanello, Cristina Bianca Quattrone, Fabrizia Veronesi, Chiara Brachelente
Summary: This study aimed to evaluate the ability of immunohistochemistry and quantitative PCR methods to detect Leishmania infection in skin biopsies with lymphoplasmacytic/histiocytic and/or granulomatous dermatitis diagnoses. The study found that immunohistochemistry was the most discriminatory method for estimating the role of the parasite in skin lesions in cases of moderate/severe inflammation.
PARASITES & VECTORS
(2022)
Article
Agriculture, Dairy & Animal Science
Emanuela Maria Morello, Marzia Cino, Davide Giacobino, Arturo Nicoletti, Selina Iussich, Paolo Buracco, Marina Martano
Summary: AGASACA is a locally aggressive tumor with high metastatic rate to regional lymph nodes in dogs. This study evaluated the prognostic significance of Ki67 in surgically excised AGASACA and also assessed other factors related to prognosis. Results showed that lymph nodes metastasis at diagnosis reduced disease free interval, while tumor size, lymphatic and vascular invasion, and a solid histologic pattern were associated with shorter survival time in dogs with metastasis to regional lymph nodes. Ki67 expression was not significantly associated with prognosis.
Article
Oncology
Veronica C. Shim, Robin J. Baker, Wen Jing, Roisin Puentes, Sally S. Agersborg, Thomas K. Lee, Wamda Goreai, Ninah Achacoso, Catherine Lee, Marvella Villasenor, Amy Lin, Malathy Kapali, Laurel A. Habel
Summary: The International Ki67 Working Group has developed a training program for improving the reproducibility of immunohistochemistry scoring and recommends specific cut points for prognosis in ER+, HER2-, stage I/II breast cancer. The overlap between these cut points and the Recurrence Score (RS) assay remains moderate, indicating the unclear clinical utility of using these cut points for further testing.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Cell Biology
Andrigo Barboza de Nardi, Rodrigo dos Santos Horta, Carlos Eduardo Fonseca-Alves, Felipe Noleto de Paiva, Lais Calazans Menescal Linhares, Bruna Fernanda Firmo, Felipe Augusto Ruiz Sueiro, Krishna Duro de Oliveira, Silvia Vanessa Lourenco, Ricardo De Francisco Strefezzi, Carlos Henrique Maciel Brunner, Marcelo Monte Mor Rangel, Paulo Cesar Jark, Jorge Luiz Costa Castro, Rodrigo Ubukata, Karen Batschinski, Renata Afonso Sobral, Natalia Oyafuso da Cruz, Adriana Tomoko Nishiya, Simone Crestoni Fernandes, Simone Carvalho dos Santos Cunha, Daniel Guimaraes Gerardi, Guilherme Sellera Godoy Challoub, Luiz Roberto Biondi, Renee Laufer-Amorim, Paulo Ricardo de Oliveira Paes, Gleidice Eunice Lavalle, Rafael Ricardo Huppes, Fabrizio Grandi, Carmen Helena de Carvalho Vasconcellos, Denner Santos dos Anjos, Angela Cristina Malheiros Luzo, Julia Maria Matera, Miluse Vozdova, Maria Lucia Zaidan Dagli
Summary: Mast cell tumors in dogs are a common and important type of tumor in veterinary oncology. This article presents the report and discussion on the diagnosis, prognosis, and treatment of cutaneous and subcutaneous mast cell tumors in dogs from the 2nd Consensus meeting organized by the Brazilian Association of Veterinary Oncology in August 2021.
Article
Veterinary Sciences
Shawna Klahn, Nikolaos Dervisis, Kevin Lahmers, Marian Benitez
Summary: The study found that short-term anti-inflammatory glucocorticoid treatment does not appear to have a significant impact on the histological features and proliferation indices of canine MCTs.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Kristina Tekavec, Tanja Svara, Tanja Knific, Jernej Mlakar, Mitja Gombac, Carlo Cantile
Summary: Nerve sheath tumors (NSTs) are characterized by abnormal cell growth in various types of cells. Loss of H3K27me3 expression in a subset of MNSTs has been identified as a potential diagnostic marker. In a study of 68 canine tumors previously diagnosed as NST, 25% showed loss of H3K27me3 expression, 49% had mosaic loss of expression, and 26% retained expression. However, there were no significant correlations between H3K27me3 expression and histopathological features or other markers. More research is needed to evaluate the diagnostic value of H3K27me3 loss in canine NST.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pathology
Sanna Hamalainen, Lauri Kareinen, Antti Sukura, Ilona Kareinen
Summary: This study investigates the expression of CPA3 in different tissues and tumor cells in dogs, showing three distinct labeling patterns in MCTs. CPA3 is proposed as a novel immunohistochemical marker for canine mast cells in both health and disease.
VETERINARY PATHOLOGY
(2022)
Article
Veterinary Sciences
Valentina Rinaldi, Andrea Boari, Lorenzo Ressel, Laura Bongiovanni, Paolo Emidio Crisi, Emanuele Cabibbo, Riccardo Finotello
Summary: This study found that the expression levels of CB1 and CB2 are high in low-grade cMCT, while low in high-grade cMCT.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Despoina Pouloudi, Maria Manou, Panagiotis Sarantis, Nikolaos Tsoukalas, Gerasimos Tsourouflis, Eougken Dana, Michalis V. Karamouzis, Jerzy Klijanienko, Stamatios Theocharis
Summary: This study explored the immunohistochemical expression of HDAC-1, -2, -4, and -6 in SGTs and their potential as prognostic biomarkers. The results indicated that HDAC-2 expression was associated with longer overall survival in patients with malignant SGTs, while HDAC-2 positivity and absence of HDAC-6 expression were related to prolonged survival in patients with high-grade malignant SGTs. Moreover, high HDAC-2 expression was significantly associated with longer overall survival in high-grade malignant SGT patients.
Article
Agriculture, Dairy & Animal Science
Cecilia Dall'Aglio, Margherita Maranesi, Antonio Di Loria, Diego Piantedosi, Paolo Ciaramella, Maria Chiara Alterisio, Elvio Lepri, Francesca Mercati
Summary: Adiponectin plays a crucial role in skin biology, being greatly affected by nutritional status and obesity. The study showed a negative correlation between adiponectin and ADIPOR2 skin expression and serum levels in obese dogs. This suggests that the adiponectin system in the skin undergoes changes in obesity, impacting the local functionality of tissues, including the skin.
Article
Veterinary Sciences
Hyo-Sung Kim, Han-Jun Kim, Hyun-Jeong Hwang, Jong-Hyun Ahn, Sun-Hee Do
Summary: This case study reports an extraskeletal osteosarcoma in a Maltese dog, which did not result in recurrence or metastasis after resection. Analysis revealed high expression of proliferation- and metastasis-related biomarkers in the tumor cells, along with the absence of angiogenesis-related biomarkers, suggesting a hypoxic tumor microenvironment preventing metastasis.
VETERINARY SCIENCES
(2021)
Article
Oncology
Chaofeng Yuan, Jiannan Huang, Yizhuo Wang, Huijie Xiao
Summary: The study investigates the role of Ki67, Her-2, and MutP53 proteins in predicting the progression and prognosis of CRC. A risk model, nomogram, and lymph node metastasis model were developed based on these proteins. The study found significant correlations between the expression of these proteins and various clinicopathological features of CRC. The risk model showed high predictive value for determining the pathological characteristics and prognosis of CRC. The nomogram prediction model demonstrated premium clinical value for predicting prognosis. The lymph node metastasis model incorporating these proteins showed robust predictive capacity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Veterinary Sciences
Marzia Cino, Elisa Maria Gariboldi, Damiano Stefanello, Kevin Pascal Spindler, Erica Ilaria Ferraris, Emanuela Maria Morello, Luca Bertola, Lorella Maniscalco, Marina Martano
Summary: This study investigated the predictive value of the Ki67 index in G2/LG cMCTs with HN2 lymph nodes and found that it did not have prognostic impact. The clinical outcome of dogs treated with surgery alone was good.
VETERINARY SCIENCES
(2023)
Review
Entomology
Beqe Hulaj, Izedin Goga, Armend Cana, Xhavit Merovci, Franca Rossi, Simone Crudele, Luciano Ricchiuti, Franco Mutinelli
Summary: This study confirmed the presence and distribution of American foulbrood (AFB) in honey bee colonies in the Republic of Kosovo. It also identified different genetic characteristics of the bacterial strains, providing important insights for future control strategies and training programs.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Review
Entomology
Franco Mutinelli
Summary: Euthanasia refers to the humane ending of an animal's life to minimize pain and distress, and further research is needed on methods and guidance. Euthanasia can be beneficial for animal welfare and public health in cases of certain diseases or hybrid bees.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Article
Entomology
Robert Brodschneider, Johannes Schlagbauer, Iliyana Arakelyan, Alexis Ballis, Jan Brus, Valters Brusbardis, Luis Cadahia, Jean-Daniel Charriere, Robert Chlebo, Mary F. Coffey, Bram Cornelissen, Cristina Amaro da Costa, Ellen Danneels, Jiri Danihlik, Constantin Dobrescu, Garth Evans, Mariia Fedoriak, Ivan Forsythe, Ales Gregorc, Jes Johannesen, Lassi Kauko, Preben Kristiansen, Maritta Martikkala, Raquel Martin-Hernandez, Ewa Mazur, Franco Mutinelli, Solenn Patalano, Aivar Raudmets, Noa Simon Delso, Jevrosima Stevanovic, Aleksandar Uzunov, Flemming Vejsnaes, Anthony Williams, Alison Gray
Summary: This study surveyed beekeepers in 30 European countries and found significant variations in the methods used to control Varroa destructor, a parasitic mite in honey bee colonies. The most commonly used control methods include amitraz, oxalic acid, and formic acid. The study also identified three distinct clusters in Europe based on the control methods used.
JOURNAL OF PEST SCIENCE
(2023)
Article
Entomology
Alison Gray, Adjlane Noureddine, Alireza Arab, Alexis Ballis, Valters Brusbardis, Adrian Bugeja Douglas, Luis Cadahia, Jean-Daniel Charriere, Robert Chlebo, Mary F. Coffey, Bram Cornelissen, Cristina Amaro da Costa, Ellen Danneels, Jiri Danihlik, Constantin Dobrescu, Garth Evans, Mariia Fedoriak, Ivan Forsythe, Ales Gregorc, Iliyana Ilieva Arakelyan, Jes Johannesen, Lassi Kauko, Preben Kristiansen, Maritta Martikkala, Raquel Martin-Hernandez, Ewa Mazur, Carlos Aurelio Medina-Flores, Franco Mutinelli, Eslam M. Omar, Solenn Patalano, Aivar Raudmets, Gilles San Martin, Victoria Soroker, Philip Stahlmann-Brown, Jevrosima Stevanovic, Aleksandar Uzunov, Flemming Vejsnaes, Anthony Williams, Robert Brodschneider
Summary: This article presents the managed honey bee colony loss rates across 37 countries during the winter of 2019/20. The study reveals an overall colony winter loss rate of 18.1%, higher than the previous year. The research also highlights that beekeepers with larger operations, migration practices, and a higher proportion of new queens experience lower loss rates.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Article
Veterinary Sciences
M. Carroll, E. Morello, M. Olimpo, D. Giacobino, P. Buracco, E. Ferraris
Summary: This study evaluated the feasibility and complications of using single or double random mucosal rotating flaps to close maxillary defects in dogs. The results showed that these flaps are versatile and effective in closing rostral maxillary defects, but may be associated with postoperative complications when used to close mid maxillary defects.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Erica Ilaria Ferraris, Matteo Olimpo, Davide Giacobino, Luca Manassero, Selina Iussich, Elena Lardone, Mariateresa Camerino, Paolo Buracco, Emanuela Maria Morello
Summary: This study evaluated the feasibility and sensitivity of computed tomography lymphography (CTL) in detecting the sentinel lymph node (SLN) and compared it with the most representative lymph node of the patient's lymphatic status. The results showed that CTL is a reliable method for detecting SLN and there is no need to remove other lymph nodes for staging purposes.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Virology
Martina Castellan, Gianpiero Zamperin, Giulia Franzoni, Greta Foiani, Maira Zorzan, Petra Drzewniokova, Marzia Mancin, Irene Brian, Alessio Bortolami, Matteo Pagliari, Annalisa Oggiano, Marta Vascellari, Valentina Panzarin, Sergio Crovella, Isabella Monne, Calogero Terregino, Paola De Benedictis, Stefania Leopardi
Summary: This study comprehensively characterized the Syrian hamster as an animal model for SARS-CoV-2 infection. It revealed the susceptibility and disease development in both male and female hamsters, as well as the sex-related differences in viral shedding, symptoms, and inflammatory response.
Review
Agriculture, Dairy & Animal Science
Marta De Santis, Samanta Seganfreddo, Alberto Greco, Simona Normando, Daniele Benedetti, Franco Mutinelli, Laura Contalbrigo
Summary: Heart rate (HR) and heart rate variability (HRV) are commonly used physiological measures in animals. While several studies exist on horse HRV, less information is available for donkeys. This scoping review aims to understand the extent and type of published evidence on donkey HR and HRV, their clinical and research applications, the devices used, and the analysis performed.
Article
Agriculture, Dairy & Animal Science
Matteo Olimpo, Paolo Buracco, Erica Ilaria Ferraris, Lisa Adele Piras, Lorella Maniscalco, Davide Giacobino, Andrea Degiovanni, Emanuela Morello
Summary: Local control of intramuscular sarcomas of the limbs may involve limb amputation or marginal excision plus radiotherapy. This study aims to describe a surgical procedure in three dogs affected by intramuscular sarcomas with no signs of fascial invasion. No major complications were observed and all dogs experienced rapid recovery.
Article
Entomology
Simone Belluco, Michela Bertola, Fabrizio Montarsi, Guido Di Martino, Anna Granato, Roberto Stella, Marianna Martinello, Fulvio Bordin, Franco Mutinelli
Summary: This paper discusses traditional and emerging topics related to the connection between insects and public health, emphasizing the impact insects have on human and animal health. It outlines the role of public health authorities in various sectors involving insects, health, and food, and emphasizes the need for improved rearing conditions, animal welfare, and research activities related to the insect-public health interface. The article highlights the negative aspects of insects as pests and disease vectors, as well as their potential as bioindicators of environmental pollution and as a source of food and feed. Public health professionals are encouraged to address both the negative and positive impacts of insects on health and to develop strategies that prioritize human welfare while managing insect populations. The article provides an overview of the current and future role and activities of public health authorities regarding insects.
Article
Agriculture, Dairy & Animal Science
Samanta Seganfreddo, Diletta Fornasiero, Marta De Santis, Franco Mutinelli, Simona Normando, Laura Contalbrigo
Summary: Animal welfare science is facing the challenge of quantifying animal emotions. This study focused on donkeys and aimed to identify indicators of positive or negative emotions using non-invasive parameters. The results showed differences in behavior and heart rate variability between rewarding and frustrating situations. Although the sample size was small, this preliminary investigation suggests promising outcomes for further research on emotional states in donkeys.
Article
Agriculture, Dairy & Animal Science
Matteo Olimpo, Erica Ilaria Ferraris, Lorenza Parisi, Paolo Buracco, Sara Gioele Rizzo, Davide Giacobino, Andrea Degiovanni, Lorella Maniscalco, Emanuela Morello
Summary: Saliva is an irritant of the subcutaneous tissue, leading to the development of a non-epithelial reactive pseudocapsule. Metaplastic ossification of the pseudocapsule is rarely described in veterinary literature. This case series aimed to describe three dogs with calcified salivary mucocele. Complete excision of the pseudocyst and a concurrent sialoadenectomy provided an effective treatment for this rare salivary mucocele disorder.
Article
Veterinary Sciences
Massimo Iorizzo, Sonia Ganassi, Gianluca Albanese, Francesco Letizia, Bruno Testa, Cosimo Tedino, Sonia Petrarca, Franco Mutinelli, Alessandra Mazzeo, Antonio De Cristofaro
Summary: The balance of gut microbiome is crucial for honey bee growth, immune function, and defense against pathogens. This study focused on two common lactobacillus strains associated with honey bee gut microbiota, evaluating their ability to inhibit pathogenic bacteria and characterizing their biochemical and functional properties. These findings provide potential for their use as probiotics in beekeeping and biocontrol of diseases.
VETERINARY SCIENCES
(2022)
