期刊
VETERINARY PATHOLOGY
卷 49, 期 1, 页码 5-15出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985811421324
关键词
embryonic stem cells; embryonic carcinoma cells; backcrossing; 129 strain; modifier genes; corpus callosum; phenotype; tissue-specific gene expression; site-specific recombinase technology; genetic background
Embryonic stem cells have had a significant impact on understanding gene function and gene interactions through the use of genetically engineered mice. However, the genetic context (ie, mouse strain) in which these modifications in alleles are made may have a considerable effect on the phenotypic changes identified in these mice. In addition, tissue- and time-specific gene expression systems may generate unanticipated outcomes. This article discusses the history of embryonic stem cells, reviews how mouse strain can affect phenotype (using specific examples), and examines some of the caveats of conditional gene expression systems.
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