Review
Pharmacology & Pharmacy
Xueying Zhou, Alexandra E. Hohman, Walter H. Hsu
Summary: Isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on nervous system channels, showing efficacy against various types of ectoparasites. Approval of more isoxazoline products by regulatory agencies highlights the importance of a comprehensive understanding for veterinary practitioners.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Review
Parasitology
Paul M. Selzer, Christian Epe
Summary: Antiparasitics acting on endo- or ectoparasites represent the second largest segment of the global animal health market, but few novel antiparasitic agents have been introduced in recent years. To address resistance issues, there is a clear need for novel antiparasitics with new modes/mechanisms of action.
TRENDS IN PARASITOLOGY
(2021)
Article
Microbiology
Anastasia Diakou, Dimitra Sofroniou, Barbara Paoletti, Androniki Tamvakis, Stanislav Kolencik, Dimitris Dimzas, Simone Morelli, Marika Grillini, Donato Traversa
Summary: Ticks and fleas in dogs and cats from Cyprus were investigated in this study, and vector-borne pathogens were detected in these ectoparasites. The results emphasize the importance of systematic ectoparasite control in dogs and cats.
Article
Biochemistry & Molecular Biology
Miku Kono, Fumiyo Ozoe, Miho Asahi, Yoshihisa Ozoe
Summary: This study found that fluralaner inhibits GABA receptors in the activated state by binding to the putative binding site in the transmembrane subunit interface. The GABA response was not affected in the resting state, but once inhibited, it could not be restored by repeated applications of GABA. These findings suggest that fluralaner tightly binds to the activated conformation of GABA receptors in a stepwise fashion.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Agronomy
Miho Asahi, Kohei Yamato, Fumiyo Ozoe, Yoshihisa Ozoe
Summary: This study found that the conserved external amino acid residues of insect GABAR channels play a critical role in the antagonistic effect of the inhibitor fluralaner.
PEST MANAGEMENT SCIENCE
(2023)
Article
Parasitology
Martha J. Wenger, Todd M. Kollasch, Madeline C. Burke, Livvy Jones, Casey Locklear, Makaela Hedberg, Lauren Miller, Sydnie Reeves, Debra Ritchie, Anthony J. Rumschlag, William G. Ryan, Vicki Smith, Cameron Sutherland, Kathryn E. Reif, Brian H. Herrin
Summary: The study found that lotilaner may disrupt tick attachment and cause progressive impairment of neuromuscular processes in attached ticks within 2 hours. These irreversible changes could substantially reduce the risk of pathogen transmission from tick to host.
PARASITES & VECTORS
(2021)
Article
Parasitology
Dieter Heylen, Michael Day, Bettina Schunack, Josephus Fourie, Michel Labuschange, Sherry Johnson, Samuel Maina Githigia, Foluke Adedayo Akande, Jahashi Saidi Nzalawahe, Dickson Stuart Tayebwa, Ortwin Aschenborn, Mary Marcondes, Maxime Madder
Summary: A study conducted in six countries in Africa revealed differences in tick and flea diversity in dogs, with the highest tick diversity found in Nigeria and the lowest in Namibia. There was no consistent difference between East and West Africa in terms of tick diversity.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Beatriz Salceda-Sanchez, Cecilia M. Gasca-Zarate, Karen Jimenez-Soto, Estefania Grostieta, Claudia G. Lopez-Sanchez, Juan J. Soto-Gutierrez, Miguel A. Lammoglia-Villagomez, Javier Huerta-Pena, Gabriela R. Hernandez-Carbajal, Jorge L. Chagoya-Fuentes, Edelmira Jacome-Sosa, Carlos D. Perez-Brigido, Gerardo G. Ballados-Gonzalez, Ingeborg Becker, Sokani Sanchez-Montes
Summary: Fleas and ticks are common ectoparasites that infest companion animals, and some species in Mexico can carry Rickettsia felis. This study in the state of Puebla, Mexico, identified the presence of Rickettsia felis in Ctenocephalides felis fleas and Rhipicephalus sanguineus ticks, providing new information on the distribution of this pathogen in Central America.
ZOONOSES AND PUBLIC HEALTH
(2023)
Article
Parasitology
Katharine Costa dos Santos, Eric Tielemans, Andre Antonio Cutolo, Paula Elisa Brandao Guedes, Tatiani Vitor Harvey, Jamille Bispo de Carvalho Teixeira, Rebeca Costa Vitor, Anaia da Paixao Seva, Adan William de Melo Navarro, Ana Carolina Ribeiro Lima, Karin Denise Botteon, Thammy Vieira Bittar, George Rego Albuquerque, Fernando de Almeida Borges, Frederic Beugnet, Renata Santiago Alberto Carlos
Summary: This study assessed the efficacy of NexGard Spectra (R) against canine tungiasis and proved its high effectiveness. In addition to benefiting the health and welfare of treated dogs, the use of this product may have a one-health benefit on human cases by controlling the main reservoir of sand fleas.
PARASITES & VECTORS
(2023)
Article
Parasitology
Andrei Daniel Mihalca, Georgiana Deak, Luciana Catalina Panait, Stefan Rabei, Frederic Beugnet
Summary: This study evaluated the efficacy of afoxolaner, an isoxazoline class compound, in treating natural infestation of chewing lice in domestic dogs. The results showed that afoxolaner demonstrated 100% curative efficacy, suggesting it as a feasible treatment option for chewing lice in dogs.
PARASITES & VECTORS
(2022)
Article
Parasitology
Kathryn Duncan, Anne W. Barrett, Susan E. Little, Kellee D. Sundstrom, Frank Guerino
Summary: Treating heartworm-infected dogs with fluralaner limits the survival of infected mosquitoes, reducing the transmission of D. immitis.
PARASITES & VECTORS
(2023)
Article
Parasitology
Rossella Panarese, Roberta Iatta, Jairo Alfonso Mendoza-Roldan, Andrea Zatelli, Frederic Beugnet, Domenico Otranto
Summary: The study results showed that afoxolaner is effective in reducing the transmission of D. immitis and L. infantum, with a significant difference in seasonal incidence only observed for D. immitis infection. Preventive measures are recommended throughout the year in endemic areas to reduce the risk of pathogen transmission.
PARASITES & VECTORS
(2021)
Article
Parasitology
Thomas Geurden, Sara Chapin, John W. McCall, Abdelmoneim Mansour, Sean P. Mahabir, Kristina Kryda, Tom McTier
Summary: A study found that Sarolaner, an insecticide, has excellent efficacy against mosquitoes. A single oral dose of Sarolaner provides high efficacy against mosquitoes in dogs within 24-72 hours after exposure for an entire month.
PARASITES & VECTORS
(2023)
Article
Parasitology
M. Cecilia Ezquiaga, Jorge A. Gallo, Romina L. D'Agostino, Daniel E. Udrizar Sauthier, Agustin M. Abba, Juliana Sanchez
Summary: This study investigated the diversity of arthropod parasites in two armadillo species in the Argentinean Patagonia, revealing stable associations between the parasites and their hosts throughout their geographical distribution.
Article
Microbiology
Lingzhi Dong, Yaben Li, Caixin Yang, Jian Gong, Wentao Zhu, Yuyuan Huang, Mimi Kong, Lijun Zhao, Feifei Wang, Shan Lu, Ji Pu, Jing Yang
Summary: In this study, the microbiota of ticks and fleas from Marmota himalayana in the Qinghai-Tibet Plateau was investigated. The study identified potentially pathogenic new species and common pathogens such as Anaplasma phagocytophilum. These findings contribute to our understanding of the pathogens carried by marmots.
FRONTIERS IN MICROBIOLOGY
(2023)