Article
Parasitology
Katerina Skulinova, Jan Novak, Libuse Kolarova, Martin Kasny
Summary: This study aimed to discover new specific antigenic proteins for routine serological methods of larval toxocarosis. Four recombinant protein antigens were successfully prepared and showed good correlation with Toxocara excretory-secretory products in ELISA and Western blot analysis. These findings offer the possibility of effective identification of Toxocara protein antigens for routine serodiagnosis of larval toxocarosis.
ACTA PARASITOLOGICA
(2022)
Article
Veterinary Sciences
Paul M. Airs, Claire Brown, Erica Gardiner, Liz Maciag, Jamie P. Adams, Eric R. Morgan
Summary: This study found a widespread presence of Toxocara eggs in soil samples from parks and recreational areas in the UK and Ireland, indicating a need for further efforts to reduce egg shedding from pet dogs.
Article
Parasitology
Lisa M. Young, Scott Wiseman, Elizabeth Crawley, Dwight D. Bowman, Craig R. Reinemeyer, Daniel E. Snyder
Summary: The study showed that the Credelio Plus combination tablet was highly effective against experimental infections of immature stages of T. canis, with worm counts exceeding 98.6% and 96.8% in the two dose confirmation studies.
PARASITES & VECTORS
(2021)
Article
Parasitology
Marie-Kristin Raulf, Daniela Jordan, Herbert Auer, Jens M. Warnecke, Bernd Lepenies, Christina Strube
Summary: This study evaluated the newly developed Anti-Toxocara-ELISA and Anti-Toxocara-Westernblot prototypes, which showed high sensitivity and specificity, indicating high reliability of these newly developed tests.
Article
Public, Environmental & Occupational Health
Ruana Renostro Delai, Aaronson Ramathan Freitas, Louise Bach Kmetiuk, Yslla Fernanda Fitz Balo Merigueti, Isabella Braghin Ferreira, Susana Angelica Zevallos Lescano, William Henry Roldan Gonzales, Ana Perola Drulla Brandao, Ivan Roque de Barros-Filho, Christina Pettan-Brewer, Fabiano Borges Figueiredo, Andrea Pires dos Santos, Claudia Turra Pimpao, Vamilton Alvares Santarem, Alexander Welker Biondo
Summary: The study assessed the seroprevalence of anti-Toxocara antibodies in human seashore populations, presence of eggs in dogs and environmental samples in southern Brazil. The high prevalence observed may be due to exposure to contaminated sand and climatic factors favoring frequent exposure to Toxocara spp.
Article
Parasitology
Iman F. Abou-El-Naga, Nermine M. F. H. Mogahed
Summary: Toxocara canis larvae invade various tissues of different vertebrate species without developing into adults in the paratenic host. Despite exposure to the host's immune response, the larvae can survive long-term through modulating the immune response. This ability is attributed to the secretion of Toxocara excretory-secretory products (TESPs), which interact with host molecules, affect the innate immune response, and play a role in tissue repair. Understanding the molecular basis of nematode pathogenicity and identifying helminth molecules with immunomodulatory potential could have implications in disease treatment.
Article
Immunology
Cheng-You Lu, Shih-Chan Lai, Hsiu-Hsiung Lee, Hui-Tan Chien, Kuang-Pin Lan, Ke-Min Chen
Summary: The study on pulmonary pathological alteration caused by T. canis infection revealed that the pathological effects gradually increased post-infection, particularly severe leukocyte infiltration and hemorrhage from days 4-14. Additionally, T. canis infection significantly increased the activity of matrix metalloproteinase (MMP)-9 and MMP-2 in the lungs, leading to pulmonary pathogenesis.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Agriculture, Dairy & Animal Science
Wen-Bin Zheng, Lang Cai, Yang Zou, Wen-Wei Gao, Qing Liu, Xing-Quan Zhu
Summary: This study examined the expression of miRNAs in the serum of Beagle dogs infected with T. canis using RNA sequencing technology and identified several differently expressed miRNAs. The results indicated that T. canis infection can alter the expression of miRNAs in the serum of Beagle dogs and provided baseline data for further research on the regulatory signaling networks involved in the pathogenesis of toxocariasis.
Article
Parasitology
Sara R. R. Healy, Eric R. R. Morgan, Joaquin M. M. Prada, Martha Betson
Summary: This study investigated the presence of Toxocara spp. eggs on spinach grown on commercial farms in the UK. The results showed that 23% of the samples tested positive for T. canis and 1.7% for T. cati. This highlights the importance of thorough washing of vegetables and implementing effective farm biosecurity measures to reduce the risk of contamination.
PARASITES & VECTORS
(2023)
Review
Veterinary Sciences
Karine Cristine Almeida, Fernanda Pinto-Ferreira, Italmar Teodorico Navarro, Kamila Libano Souza, Leticia Santos Balbino, Juliana Correa Bernardes, Danielle Louisy Bahia dos Santos, Margarete Kimie Falbo
Summary: This study aimed to investigate the occurrence of zoonotic enteroparasites in dog feces from public places in Guarapuava, Brazil, and assess the knowledge of dog owners about zoonoses and public health risks. The results showed a high infection rate of zoonotic parasites in dog feces collected from public shelters, squares, parks, and roads. The survey also revealed that some dog owners did not collect their animals' feces, did not administer deworming treatments to their dogs, and were unaware of the diseases transmitted by feces.
TOPICS IN COMPANION ANIMAL MEDICINE
(2024)
Article
Microbiology
Patrick Waindok, Simone Kann, Andres Aristizabal, Juan Carlos Dib, Christina Strube
Summary: The indigenous Wiwa tribe in northeast Colombia lack access to clean drinking water and sanitary installations, leading to a high risk of zoonotic roundworm infections. Research shows a seropositivity rate as high as 79.3% among the population in different villages, with adults showing the highest rate.
Article
Immunology
Hao-Yu Li, Yang Zou, Hany M. Elsheikha, Yue Xu, Lang Cai, Shi-Chen Xie, Xing-Quan Zhu, Wen-Bin Zheng
Summary: A global lipidomic analysis was conducted on the liver of beagle dogs infected with Toxocara canis using liquid chromatography-tandem mass spectrometry, revealing potential roles of lysophospholipids in the migration and development of the parasite during the early infection stage. Pathway analysis demonstrated significant alterations in immune-inflammatory pathways following infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Any Docu Axelerad, Alina Zorina Stroe, Anca Elena Gogu, Agneta Pusztai, Dragos Catalin Jianu, Duta Daniel, Daniel Docu Axelerad
Summary: This review examines the clinical symptomatology of neurotoxocariasis in the last 7 decades, focusing on human helminth zoonosis and the neurological effects caused by Toxocara infection. By analyzing detected and diagnosed cases, the review aims to raise awareness of the neurological implications of Toxocara infection.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Yue Xu, Hao-Yu Li, Lang Cai, Shi-Chen Xie, Yang Zou, Xing-Quan Zhu, Wen-Bin Zheng
Summary: This study conducted transcriptome profiling of miRNA expression in the spleen of Beagle puppies after T. canis infection, identifying several differentially expressed miRNAs that play significant roles in the pathogenesis of toxocariasis, such as cfa-miR-206, cfa-miR-331, and cfa-miR-339.
Article
Parasitology
Vamilton Alvares Santarem, Giovanni Kalempa Panazzolo, Louise Bach Kmetiuk, Orlei Jose Domingues, Isabella Braghin Ferreira, Roberto Teixeira de Souza Filho, Joao Henrique Farinhas, Fernando Rodrigo Doline, Susana Angelica Zevallos Lescano, Leandro Meneguelli Biondo, Rogerio Giuffrida, Alexander Welker Biondo, Giovani Marino Favero
Summary: The high vulnerability and seroprevalence observed in quilombola communities in Brazil highlight the need for a One Health approach to detect, monitor, and prevent infection by Toxocara spp. in both human and dog populations.
PARASITES & VECTORS
(2023)