Review
Ophthalmology
Zhenyu Zhong, Guannan Su, Aize Kijlstra, Peizeng Yang
Summary: Uveitis is a group of diseases characterized by intraocular inflammation, some of which are driven by auto inflammatory or autoimmune responses, and share the activation of the IL-23/IL-17 pathway. Emerging drugs blocking this pathway have been assessed for the treatment of uveitis.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Izabela Wos, Jacek Tabarkiewicz
Summary: Rheumatic diseases are complex autoimmune diseases characterized by inflammation and joint pain, requiring long-term treatment. Early detection and appropriate preventative measures are important. Research shows that during inflammation, both pro-inflammatory and anti-inflammatory factors are present, and improving the quality of life of patients can be achieved through targeting inflammatory pathways.
IMMUNOLOGIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yukio Takamori, Takehiro Ando, Masashi Sato, Santhana Vedi, Daisuke Fuji, Takumi Yokoyama, Keita Tsukamoto, Mizuki Yamamoto, Takashi Kawakami
Summary: The RNA aptamer selected against IL-23 through SELEX can bind to IL-23 and inhibit interaction between IL-23 and IL-23R, showing potential for the treatment of inflammatory autoimmune diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Michelle Martin de Bustamante, Diego Gomez, Jennifer MacNicol, Ralph Hamor, Caryn Plummer
Summary: Equine recurrent uveitis is not associated with alteration of the gastrointestinal bacterial microbiota when compared with healthy controls.
Article
Immunology
Yujing Qian, Ru Yu, Chan Zhao, Fei Gao, Meifen Zhang
Summary: The study found that serum IL-33 levels are significantly increased in VKH patients among the Chinese Han population, and are positively correlated with disease activity and relapses. This suggests that IL-33 may be involved in the pathogenesis of VKH and could potentially serve as a biomarker for the disease.
CLINICAL IMMUNOLOGY
(2021)
Article
Ophthalmology
Guomin Jiang, Juan Yun, Henry J. Kaplan, Yuan Zhao, Deming Sun, Hui Shao
Summary: Circulating exosomes have immunoregulatory functions in autoimmune uveitis, selectively inhibiting immune responses of specific T cells and reducing the incidence of recurrent uveitis in an antigen-specific manner. This suggests the potential for circulating exosomes to be a novel treatment for recurrent autoimmune uveitis.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biochemical Research Methods
Maria Weigand, Stefanie M. Hauck, Cornelia A. Deeg, Roxane L. Degroote
Summary: The study investigated the proteome of granulocytes from equine recurrent uveitis cases and healthy controls, identifying changes in protein abundance associated with the disease, suggesting a latent activation of these innate immune cells. The findings highlight the importance of granulocytes in the T cell-driven autoimmune disease, with implications for veterinary medicine and potential translational relevance to autoimmune uveitis in humans.
JOURNAL OF PROTEOMICS
(2021)
Article
Cell Biology
Lina Wu, Lu Wang, Xin Chai
Summary: This study aims to understand the role of granulocyte-macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in the pathophysiology of mouse experimental autoimmune uveitis (EAU). The study found that ThGM cells were present in the spleen and the eye after EAU induction, and they had an impact on the severity of EAU.
CELLULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Gianluca Avallone, Carlo Alberto Maronese, Giulia Murgia, Carlo Giovanni Carrera, Luca Mastorino, Gabriele Roccuzzo, Paolo Dapavo, Silvia Alberti-Violetti, Pietro Quaglino, Simone Ribero, Angelo Valerio Marzano
Summary: This study aimed to compare the efficacy of IL-17 and IL-23 inhibitors in treating pustular and erythrodermic psoriasis. The results showed that IL-17 inhibitors had higher effectiveness in treating these conditions, while the efficacy of IL-23 inhibitors remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: Uveitis is a complex ocular inflammatory disease that can be caused by infections or autoimmune factors. While infectious uveitis can often be resolved with anti-infective therapy and corticosteroids, non-infectious uveitis requires a better understanding of inflammatory pathways to develop more effective treatments.
DRUG DISCOVERY TODAY
(2021)
Article
Immunology
Katsuyuki Takeda, Tracy L. Webb, Fangkun Ning, Yoshiki Shiraishi, Daniel P. Regan, Lyndah Chow, Mia J. Smith, Shigeru Ashino, Amanda M. Guth, Sophie Hopkins, Erwin W. Gelfand, Steven Dow
JOURNAL OF IMMUNOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ron C. Gaba, Nasya Mendoza-Elias, Daniel P. Regan, Kelly D. Garcia, R. Peter Lokken, Regina M. Schwind, Michael Eichner, Faith M. Thomas, Lauretta A. Rund, Lawrence B. Schook, Kyle M. Schachtschneider
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2018)
Review
Pharmacology & Pharmacy
Daniel L. Gustafson, Dawn L. Duval, Daniel P. Regan, Douglas H. Thamm
PHARMACOLOGY & THERAPEUTICS
(2018)
Meeting Abstract
Oncology
Kyle M. Schachtschneider, Nasya Mendoza-Elias, Daniel P. Regan, Kelly D. Garcia, Lauretta A. Rund, Regina M. Schwind, Lawrence B. Schook, Ron C. Gaba
Article
Immunology
Daniel P. Regan, Jonathan W. Coy, Kirti Kandhwal Chahal, Lyndah Chow, Jade N. Kurihara, Amanda M. Guth, Irina Kufareva, Steven W. Dow
JOURNAL OF IMMUNOLOGY
(2019)
Article
Nutrition & Dietetics
Aaron M. Magnuson, Daniel P. Regan, Andrea D. Booth, Josephine K. Fouts, Claudia M. Solt, Jessica L. Hill, Steve W. Dow, Michelle T. Foster
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Cell Biology
Christina G. Towers, Brent E. Fitzwalter, Daniel Regan, Andrew Goodspeed, Michael J. Morgan, Chang-Wei Liu, Daniel L. Gustafson, Andrew Thorburn
DEVELOPMENTAL CELL
(2019)
Article
Veterinary Sciences
Tiffany Wormhoudt Martin, Lynn Griffin, James Custis, Stewart D. Ryan, Mary Lafferty, Mary-Keara Boss, Daniel Regan, Sangeeta Rao, Del Leary, Stephen J. Withrow, Susan M. LaRue
Summary: Canine appendicular osteosarcoma can be effectively treated with stereotactic body radiation therapy (SBRT), improving lameness in most patients and achieving >80% tumor necrosis in 50% of cases for local disease control. While some patients may experience fractures and require amputation after treatment, dogs who undergo salvage amputation have a significantly longer median survival time compared to those who do not. Metastatic disease at the time of treatment does not significantly impact survival time.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Pathology
Joanne L. Tuohy, Brittney J. Byer, Suzanne Royer, Charles Keller, Margaret A. Nagai-Singer, Daniel P. Regan, Bernard Seguin
Summary: This study showed that MyoD1 and myogenin should be included in a diagnostic IHC panel along with desmin for canine RMS, in order to improve accuracy of diagnosis. Additionally, the research on clinical presentation and survival outcomes of canine RMS lays the groundwork for future comparative investigations.
VETERINARY PATHOLOGY
(2021)
Article
Pathology
Lauren N. Alfino, Kai C. Wilczewski-Shirai, Kathryn E. Cronise, Jonathan Coy, Kristina Glapa, E. J. Ehrhart, Joseph B. Charles, Dawn L. Duval, Daniel P. Regan
Summary: Periostin is an important matricellular protein involved in regulating bone, tooth, and cardiac development, but also plays a role in inflammatory diseases and certain cancers. In this study, periostin expression was found to be significantly upregulated in canine osteosarcoma tumors, but not associated with time to metastasis. Tumors with high periostin expression showed activation of pro-tumorigenic pathways, while tumors with low periostin expression showed enhanced anti-tumor immune responses.
VETERINARY PATHOLOGY
(2021)
Article
Orthopedics
Anthony Romeo, Jeremiah Easley, Dan Regan, Eileen Hackett, James Johnson, Jed Johnson, Christian Puttlitz, Kirk McGilvray
Summary: This study evaluated the mechanical, structural, and histologic quality of rotator cuff repairs using an interposition nanofiber scaffold composed of polyglycolic acid-poly-L-lactide-co-epsilon-caprolactone in an acute sheep model. The results demonstrated that using the scaffold enhanced the repair strength and facilitated the formation of a tissue structure similar to the natural shoulder cuff attachment.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Veterinary Sciences
Kathryn E. Cronise, Sunetra Das, Belen G. Hernandez, Daniel P. Regan, Deanna D. Dailey, Robert McGeachan, Susan E. Lana, Rodney L. Page, Daniel L. Gustafson, Dawn L. Duval
Summary: Transitional cell carcinoma is the most common type of bladder cancer in humans and dogs, with high metastatic risk. Canine transitional cell carcinoma serves as a model for evaluating novel therapies for human muscle-invasive TCC. Molecular characterization revealed a high prevalence of BRAF variants in canine TCC, suggesting potential therapeutic targets for both human and canine cancers.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Oncology
Daniel P. Regan, Lyndah Chow, Sunetra Das, Laurel Haines, Eric Palmer, Jade N. Kurihara, Jonathan W. Coy, Alissa Mathias, Douglas H. Thamm, Daniel L. Gustafson, Steven W. Dow
Summary: The combination of losartan and toceranib has significant clinical benefits in the treatment of osteosarcoma, as demonstrated in dog models.
CLINICAL CANCER RESEARCH
(2022)
Article
Pathology
Brittany M. Wittenberns, Douglas H. Thamm, Eric P. Palmer, Daniel P. Regan
Summary: Splenic stromal sarcomas are rare with heterogeneous outcomes in dogs after treatment by splenectomy. Evaluating histopathology and immunohistochemistry is important to differentiate benign lesions from more aggressive malignancies in clinical diagnosis of splenic tumors.
JOURNAL OF COMPARATIVE PATHOLOGY
(2021)
Article
Orthopedics
Kevin T. Credille, Zachary R. C. Wang, Nolan S. Horner, Daniel P. Regan, Benjamin C. Gadomski, Jeremiah T. Easley, Grant E. Garrigues, Adam B. Yanke
Summary: This study performed a histological assessment of a biphasic acellular interpositional cancellous allograft in a sheep model of rotator cuff repair (RCR) to evaluate its safety profile and effects on tendon healing after RCR. The results showed that the allograft was equivalent to standard repair in terms of inflammation and tissue healing, indicating its potential for further clinical investigation in humans.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)