Review
Engineering, Biomedical
Dong Liu, Ting Wang, Yuan Lu
Summary: The article discusses the potential applications of untethered microrobots in medical treatment, particularly focusing on the advantages of active drug delivery systems compared to traditional passive systems. It introduces an integrated 5D radar chart analysis model and addresses the various factors that need to be considered before clinical application of microrobots.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Pedro P. G. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S. Dennis, Claudia Loebel, Amanda Chung, Sarah J. Shepherd, Rebecca M. Haley, Alex G. Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G. Anderson, Ruben D. Carrasco, Michael J. Mitchell
Summary: Multiple myeloma (MM) is a hematologic malignancy that colonizes the bone marrow and lacks effective therapies. Endothelial cells in the bone marrow microenvironment, specifically Cyclophilin A (CyPA), play a critical role in MM progression and chemotherapeutic resistance. In this study, researchers developed a nanoparticle-based approach using RNA interference (RNAi) technology to target CyPA and inhibit MM cell extravasation. The strategy demonstrated promising results in vitro and in a murine xenograft model, indicating its potential as a therapeutic strategy for MM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Carolyn K. Jons, Abigail K. Grosskopf, Julie Baillet, Jerry Yan, John H. Klich, Olivia M. Saouaf, Eric A. Appel
Summary: This study evaluates the correlation between hydrogel rheology and depot formation and persistence following subcutaneous administration. The study finds that yield stress predicts initial depot formation, while creep predicts longer depot persistence for physically cross-linked hydrogels.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Faiza Benaouda, Ricardo Inacio, Chui Hua Lim, Haeeun Park, Thomas Pitcher, Mohamed A. Alhnan, Mazen M. S. Aly, Khuloud Al-Jamal, Ka-lung Chan, Rikhav P. Gala, Daniel Sebastia-Saez, Liang Cui, Tao Chen, Julie Keeble, Stuart A. Jones
Summary: This study demonstrates a novel method for needleless delivery of advanced therapies using a skin patch. By opening the skin appendages with a hypobaric chamber, direct delivery of vaccine antigens and drug nanoparticles was achieved. The patch was shown to enhance immune response to vaccine antigens and effectively reduce rat paw swelling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Binura Perera, Yuao Wu, Nam-Trung Nguyen, Hang Thu Ta
Summary: Atherosclerosis, the main cause of cardiovascular diseases, is difficult to effectively treat in the later stages. Nanomaterials and nanoparticle-mediated therapies provide a targeted and controlled release of therapeutics, which can effectively resolve atherosclerotic plaque.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Nicholas G. Lamson, Katherine C. Fein, John P. Gleeson, Alexandra N. Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R. Melamed, Rebecca L. Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F. Schmidt, Gloria L. Silva, Kathryn A. Whitehead
Summary: The study found that strawberry and its red pigment pelargonidin can serve as effective enhancers for oral absorption of macromolecules, with minimal adverse effects and significant bioactivity in mouse models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany, Hamdy Abdelkader
Summary: Chronic ocular diseases have a significant impact on vision and the potential to cause blindness. Developing sophisticated, long-acting drug delivery systems is crucial for treating these conditions. This review explores non-invasive drug delivery nanocarriers that can control chronic eye disorders, although most are still in preclinical or clinical stages.
Article
Chemistry, Multidisciplinary
Baris A. Borsa, Luiza I. Hernandez, Tania Jimenez, Chaitanya Tellapragada, Christian G. Giske, Frank J. Hernandez
Summary: The researchers reported a nanocarrier system that delivers nucleoside analogues in a target-specific manner, making nucleoside-based therapeutics safer and with the possibility to be used in other human conditions. They demonstrated that this system can specifically inhibit the growth of gram-positive bacteria and effectively treat bacterial infections in a mouse model, with no signs of toxicity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Cheng Yang, Qianni Wu, Junqing Liu, Jingshan Mo, Xiangling Li, Chengduan Yang, Ziqi Liu, Jingbo Yang, Lelun Jiang, Weirong Chen, Hui-jiuan Chen, Ji Wang, Xi Xie
Summary: The study presents an integrated wireless theranostic contact lens that can wirelessly track intraocular pressure and offer on-demand anti-glaucoma drug delivery. The contact lens has a compact design, with a highly sensitive intraocular pressure sensing module and an efficient drug delivery module, making it a promising system for glaucoma treatments.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Min Zhou, Yong-Jiang Li, Yu-Cheng Tang, Xin-Yan Hao, Wen-Jie Xu, Da-Xiong Xiang, Jun-Yong Wu
Summary: Extracellular vesicles (EVs), including apoptotic bodies (ABs), have emerged as promising candidates for various biomedical applications. ABs, derived from parent cells during the final stages of apoptosis, possess diverse sources and stable morphological features. They accommodate more functional biomolecules due to their larger volume and exhibit advantageous interactions with recipient cells through their predominant body surface ratio. ABs hold great potential in modulating and alleviating symptoms of numerous diseases, and have also been applied in disease diagnosis, immunotherapy, regenerative therapy, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Shuangjiang Yu, Hongcheng Sun, Yongguang Li, Shu Wei, Jiayun Xu, Junqiu Liu
Summary: The idea of using engineered bacteria as living therapeutic agents for treating various diseases has been proposed, with a focus on the importance of developing safe and effective treatment strategies. Hydrogels are seen as promising vehicles for delivering living bacterial therapeutics due to their adjustable properties, bioactivities, and ability to protect labile payloads. Current challenges and future prospects in the field are discussed, indicating that the significance of hydrogel-based living bacteria-mediated therapy is expected to increase with advancements in synthetic biology and biomaterials science.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Luyao Shen, Pengfei Wang, Yonggang Ke
Summary: DNA nanotechnology has led to the creation of programmable nanostructures through Watson-Crick base pairing, with applications in biosensors and cancer therapy. The inherent addressability of DNA nanostructures allows them to interact with various biological molecules, offering potential for therapeutic applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Dan Luo, Xue Lin, Yun Zhao, Jialing Hu, Fengye Mo, Gege Song, Zhiqiao Zou, Fuan Wang, Xiaoqing Liu
Summary: DNAzyme-mediated gene regulation and photodynamic cancer therapy achieved using dynamic DNA nanomaterials with self-enhanced efficacy, providing a potential therapeutic approach for gene modulation.
Review
Biotechnology & Applied Microbiology
Xiujuan Yin, Zhenqiang He, Weiying Ge, Zhenhua Zhao
Summary: Cancer is a major cause of human death worldwide. Traditional cancer treatments have limitations, such as recurrence, poor efficacy, and side effects. Targeted therapy using aptamer-functionalized nanomaterials (AFNs) has become a hot topic, due to the high stability, affinity, and selectivity of aptamers. AFNs have shown promising applications in targeted therapy for various types of tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Veterinary Sciences
Yael L. Hack, Elizabeth E. Crabtree, Felipe Avila, Roger B. Sutton, Robert Grahn, Annie Oh, Brian Gilger, Rebecca R. Bellone
Summary: A genetic cause for congenital stationary night blindness (CSNB) in Tennessee Walking Horses was identified through whole-genome sequencing, revealing a missense mutation in the GRM6 gene. This mutation is predicted to be deleterious, affecting the signaling from retinal rod cells to ON-bipolar cells. The allele frequency of this variant in Tennessee Walking Horses is 10%.
EQUINE VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
N. E. Himebaugh, B. C. Gilger
Summary: This retrospective case series study found that positive leptospiral testing results were associated with younger horses and ocular posterior segment clinical disease, leading to poor prognosis for vision in horses with aqueous humour titres to any leptospiral serotype, especially L. bratislava serovar.
EQUINE VETERINARY EDUCATION
(2022)
Review
Biochemistry & Molecular Biology
Brian C. Gilger, Matthew L. Hirsch
Summary: This paper reviews the role of human leukocyte antigen G (HLA-G) in the eye, explores the potential therapeutic applications of AAV gene transfer and expression of HLA-G in different ocular tissues, and discusses the efficacy of these treatments in animal models of various eye diseases. The findings suggest that AAV-HLA-G could be an effective treatment for immune-mediated, inflammatory, and neovascular diseases of the eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Tara M. Stonex, Ashley E. Zibura, Michael Andres, Brian C. Gilger, Annie Oh
Summary: This study describes the use of 1% polidocanol as the sole treatment for a superficial orbital venous malformation in a horse. The results show that polidocanol treatment was well tolerated and led to clinical improvement in the horse.
VETERINARY OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
Brian C. Gilger
Summary: This article discusses the importance of studying immune-mediated ocular diseases in the development of innovative therapies, such as cell and gene therapy. Recent studies on cell and gene therapy are reviewed to highlight the significance of One Health initiatives in treating ocular diseases. The results suggest that autologous subconjunctival BM-MSC therapy may be a promising alternative treatment for immune-mediated ocular diseases.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Brian C. Gilger
Summary: This article reviews naturally occurring ocular diseases in animals and emphasizes how understanding these diseases contributes to one health initiatives, particularly in the context of common ocular diseases shared by animals and humans.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Elizabeth Crabtree, Katy Uribe, Sara M. Smith, Darby Roberts, Jacklyn H. Salmon, Jacquelyn J. Bower, Liujiang Song, Prabhakar Bastola, Matthew L. Hirsch, Brian C. Gilger
Summary: This study investigated the therapeutic efficacy of AAV8-Equine-IL10 gene therapy for the treatment of experimental autoimmune uveitis (EAU) in rats. The results showed that AAV8-Equine-IL10 treatment effectively reduced inflammation and cell counts, indicating its potential as a safe and effective treatment for uveitis.
Editorial Material
Veterinary Sciences
Brian C. Gilger
EQUINE VETERINARY EDUCATION
(2023)
Article
Ophthalmology
Nicole E. Himebaugh, James B. Robertson, Keith Weninger, Brian C. Gilger, Bjorn Ekesten, Annie Oh
Summary: The study aimed to assess the transmission of UV radiation through intact enucleated globes of different species using spectrophotometry. The results showed that cats and dogs allowed the most transmission of UV radiation, while pigs and humans allowed the least. A small amount of transmission was detected in the globes of rabbits and horses. These findings will support further vision research for training companion, working, and service animals.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Veterinary Sciences
Hannah L. Smith, Alix K. Berglund, James B. Robertson, Lauren V. Schnabel, Richard J. McMullen, Brian C. Gilger, Annie Oh
Summary: The study aimed to investigate the effect of gentamicin on CD3+ T-lymphocyte proliferation and cell viability using an in vitro cell culture model. Three adult horses were used for the experiment. Peripheral blood lymphocytes were treated with different concentrations of gentamicin and stimulated to proliferate. Live cell counts and fluorescent intensity data were collected. Statistical analysis showed no significant differences between gentamicin concentrations or formulations in terms of cell viability and proliferation. The results suggest that low-dose intravitreal gentamicin may not suppress the immune response.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Jacob P. Nilles, Darby Roberts, Jacklyn H. Salmon, Liujiang Song, Carly O'Dea, Lindsay T. Marjoram, Jacquelyn J. Bower, Matthew L. Hirsch, Brian C. Gilger
Summary: This study evaluated the efficacy of adeno-associated virus (AAV) gene therapy encoding human leukocyte antigen G (HLA-G) to inhibit ocular graft versus host disease (OGvHD). The results showed that eyes treated with AAV had significantly reduced clinical signs of OGvHD and lower limbal mononuclear cell count. These findings support the potential of HLA-G-based gene therapy as an effective treatment for OGvHD.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)
Article
Veterinary Sciences
Elizabeth Esdaile, Kelly E. Knickelbein, Callum G. Donnelly, Michelle Ferneding, Monica J. Motta, Brett D. Story, Felipe Avila, Carrie J. Finno, Brian C. Gilger, Lynne Sandmeyer, Sara Thomasy, Rebecca R. Bellone
Summary: This study identifies the presence of congenital stationary night blindness (CSNB) in multiple horse breeds and identifies the genetic variations associated with this disease. The study also provides recommendations for treatment, emphasizing the importance of genetic testing in horses with the identified genetic variations.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Microbiology
Darby Roberts, Jacklyn Salmon, Marc A. Cubeta, Brian C. Gilger
Summary: This study aims to explore the differences in fungal response to topical antifungal treatment at different stages of fungal keratitis (FK) development. The results show that fungal development stage is correlated with efficacy, and traditional antifungal susceptibility testing methods are not applicable to more advanced developmental stages. A revised method of antifungal susceptibility testing may better predict fungal response in the clinical setting.
Article
Veterinary Sciences
Brian Christopher Gilger
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
(2023)
Article
Cell & Tissue Engineering
Nasif Mahmood, Taylor Cook Suh, Kiran M. Ali, Eelya Sefat, Ummay Mowshome Jahan, Yihan Huang, Brian C. Gilger, Jessica M. Gluck
Summary: Deficiency and dysfunction of corneal cells can lead to blindness in corneal diseases. However, there is a lack of adequate cell sources for regenerative cell therapies and engineered corneal tissue. The discovery of induced pluripotent stem cells (iPSCs) provides an opportunity to generate corneal cells autologously and in unlimited quantities. iPSCs have advantages over other stem cell sources in terms of differentiation potential and ethical concerns. They have been used to model corneal disorders and diseases, perform drug testing, and explore regenerative medicine. Building stem cell banks with HLA-homozygous cell lines can provide cost- and time-efficient allogeneic alternatives to expensive autologous treatments.
STEM CELL REVIEWS AND REPORTS
(2022)
